RESUMO
An array of carbazoles (23 examples) can be synthesized from substituted biaryl azides at 60 degrees C using substoichiometric quantities of Rh(2)(O(2)CC(3)F(7))(4) or Rh(2)(O(2)CC(7)H(15))(4).
Assuntos
Azidas/química , Compostos de Bifenilo/química , Carbazóis/síntese química , Ródio/química , Catálise , Ciclização , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Estereoisomerismo , Relação Estrutura-AtividadeRESUMO
Importin-alpha is the nuclear import receptor that recognizes cargo proteins with nuclear localization sequences (NLSs). The study of NLS peptidomimetics can provide a better understanding of the requirements for the molecular recognition of cargo proteins by importin-alpha, and potentially engender a large number of applications in medicine. Importin-alpha was crystallized with a set of six NLS peptidomimetics, and X-ray diffraction data were collected in the range 2.1-2.5 A resolution. Preliminary electron density calculations show that the ligands are present in the crystals.
