Gene-environment interplay in internalizing problem behavior.

Behavior genetic methods are useful for examining mechanisms underlying the interaction between genetic and family environmental factors of internalizing problem behavior (INT). Previous twin studies, however, have shown little consistency in interaction patterns, depending on type and operationalization of measured environments. The aim of the current study was to explore different gene-by-environment interaction patterns among different family-level environmental risk factors and resources known to correlate with INT. Using an empirical-based approach, we combined various indicators of the family environment to derive four dimensions: positive parenting, negative parenting, lack of parental resources, and socioeconomic status. We then used a genetically informed design of twins raised in the same family to test whether interaction patterns followed a diathesis stress or vantage sensitivity model formulation. The sample consisted of 2,089 twin pairs and their families from two twin birth cohorts (ages 11 and 17) participating in Wave 1 of the German TwinLife study of social inequalities. In line with a vantage sensitivity pattern of interaction and with the bioecological model of development (Bronfenbrenner & Ceci, 1994), evidence for a general mechanism of gene-environment interaction with increasing nonshared environmental variance for more adverse and less propitious family conditions was found. In preadolescence, parenting behavior had a greater moderating influence on INT compared to general family conditions like socioeconomic status. Interventions for INT that directly involve parents, thus, may be more important in preadolescent populations whereas individual interventions for adolescents may be more successful if they are adapted to different levels of socioeconomic status. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Personality traits and perception of parenting: The comparative twin study from Germany and Serbia.

This study examines the aetiology of the relationship between personality traits and perceived parenting in light of cross-cultural differences. The sample consisted of 188 Serbian and 394 German twin pairs. Personality traits were measured using the NEO-personality inventory. A Blocks Environmental Questionnaire (BEQ) was applied to measure two dimensions of perceived parenting: support and organisation. Genetic factors account for 63-79% of the variance for BEQ dimensions in both samples, while around 50-60% of the variance in Big Five personality scores could be attributed to genetic factors. The exception was Neuroticism in the Serbian sample, where the genetic effect was somewhat smaller. The results indicated similar etiological pathways of the relationship between personality traits and perceived parenting, with some cultural differences related to Neuroticism and Extraversion. Negative Neuroticism-Support and positive Extraversion-Organisation environmental relationships were stronger in the Serbian sample. Genetic overlaps were more significant in the German sample, except for the relationship of Organisation with Conscientiousness and Extraversion. This indicates that the relationship between personality and perceived parenting is largely genetically mediated, but that the environmental effect may play an important role in individual adaptation to the family setting.

Differences in Parenting Behavior are Systematic Sources of the Non-shared Environment for Internalizing and Externalizing Problem Behavior.

Although there is evidence for non-shared environmental links between parenting and problem behavior, so far, age-, informant-, and parent-specific patterns for both internalizing and externalizing problem behaviors have not been examined within one study yet. Using the twin differences design, the present study aimed to test how maternal and paternal parenting systematically act as a source of non-shared environment for problem behavior across different age groups and informants. We examined 1327 monozygotic twin pairs and their parents drawn from three birth cohorts of the German TwinLife study. Our results revealed that particularly child-reported less positive and more negative parenting by both parents contribute significantly to the unique environmental variance of problem behavior, although we did not find a clear pattern across age groups. Our study underlines the necessity of controlling for genetic confounding to uncover the truly environmentally mediated (and thus environmentally influenceable) pathways between parenting and problem behavior. A practical implication could be that it may be useful to primarily consider the child's perspective and focus on maternal as well as paternal parenting in interventions that address parenting to reduce problem behavior.

Quantitative behavioral genetic and molecular genetic foundations of the approach and avoidance strategies.

Two studies examined genetic and environmental influences on traits proposed by the revised Reinforcement Sensitivity Theory (rRST) of personality. Both quantitative and molecular behavioral genetic methods were applied considering the effects of COMT, DRD2, HTR1A and TPH2 single nucleotide polymorphisms (SNPs). Study one included 274 monozygotic and 154 dizygotic twins for the quantitative behavioral study; and in study two there were 431 twins for the molecular genetic study. The Reinforcement Sensitivity Questionnaire was used to assess basic personality traits defined by the rRST. Univariate biometric modeling suggested that genetic influences accounted for 34-44% of variance of Behavioral Approach System (BAS), Behavioral Inhibition System (BIS) and Fight-Fligh-Freeze System. Molecular genetic analyses proposed the significant main effect of COMT SNP on the BAS and TPH2 SNP on the BIS, and pointed out epistatic effects of COMT x DRD2 on BAS and HTR1A x TPH2 on Fight. Results demonstrated substantial heritability for all rRST constructs, as well as for differences in the molecular genetic basis of both approach-related and avoidance-related dimensions.

The aetiology of educational attainment: A nuclear twin family study into the genetic and environmental influences on school leaving certificates.

BACKGROUND: Educational attainment is connected to many important life outcomes, and the previous research has already focused on identifying its genetic and environmental components. However, most of these studies used twin data only and did not incorporate information from other family members. Twin studies typically decompose the phenotypic variance into genetic, shared, and unique environment components. In this study design, the shared environment component encompasses the influence of parents and the shared environments of twins and siblings independent of parents (e.g., teachers, schools, and peers). The classical twin design (CTD) conflates these influences as part of the shared environment. This shortcoming can be overcome using the nuclear twin family design (NTFD), which enables separation of the parental and shared twin/sibling environmental components. AIMS: The aim of this study was to broaden the understanding of the aetiology of educational attainment using the nuclear twin family design to provide a detailed account of the genetic and environmental effects on the type of school leaving certificate. SAMPLE: The data of 1,048 monozygotic and 916 dizygotic same-sex twins, their biological parents, and non-twin full biological siblings of the German project TwinLife were used in the nuclear twin family design. METHODS: Structural equation modelling (SEM) techniques were used to analyse the variance-covariance patterns of the ordinal outcome variable. RESULTS: Genetic influences were found to make up around 60% of variance, whilst environmental influences shared by all siblings, educational influences shared by the twins only, and non-shared environmental influences explained the remaining variance in equal amounts. Environmental transmission from parent to offspring was found to be negligible. CONCLUSION: Through its advanced design, our study extends the previous work enabling more detailed and robust estimations of sources of variance and contributes to a better understanding of the complex aetiology of educational attainment.

On the link of self-esteem, life satisfaction, and Neuroticism.

OBJECTIVE: Self-esteem (SE) and life satisfaction (LS) are highly correlated but little is known about the sources of this association. Both characteristic adaptations are negatively correlated with Neuroticism (N). We investigated the relationship between SE, LS, and N and the degree to which shared variance was explained by N from a behavior genetic perspective. METHOD: We analyzed more than 2,000 German same-sex twin pairs and their siblings. Twins were 17 and  23 years old and siblings were M = 21.6 years old. The sample was balanced regarding gender. We applied multivariate twin-sibling Cholesky models to obtain genetic and environmental correlations and estimated the impact N had on genetic and environmental correlations of SE and LS. RESULTS: The genetic correlation between SE and LS was .99 and 47% of this phenotypic correlation was explained by genetics. About 28% of the common genetic variance between SE and LS was explained by shared genes with N. CONCLUSIONS: Our findings suggest that N is not a common factor of SE and LS. The results are not in line with theories assuming that N is a basic tendency whose genetic factors account for most of the genetic variance between the assumed characteristic adaptations SE and LS.

On the etiology of internalizing and externalizing problem behavior: A twin-family study.

Internalizing and externalizing behavior problems are established risk factors for many unpleasant outcomes and psychopathology in adulthood, and understanding the interplay between genes and environment is important for deducing implications for therapeutic interventions. Among genetic studies on internalizing and externalizing problem behavior, the heritability estimates differ widely. Most research only uses twin data and other-reports, and therefore certain limitations are inevitable. Our study is the first to investigate genetic and environmental influences on problem behavior using a Nuclear Twin Family Design and self-reports, in order to address these limitations. Internalizing and externalizing problem behavior of 3,087 twin pairs (age 11-23), a sibling, and their parents were analyzed with structural equation modeling to estimate heritability separately for each of three twin birth cohorts. Genetic influences account for about one-third of the variance for both internalizing and externalizing. Shared environmental influences were only found for internalizing, and through the advantages of considering data from the whole twin family, firstly could be identified as solely twin-specific. Our findings could contribute to a better understanding of the gap between heritability based on twin studies and DNA-based heritability ('missing heritability problem'): Results indicate that heritability estimates gained via classic twin design and other-reports are slightly overestimated and therefore environmental influences, in general, are more important than previous research suggests. Simultaneously, we showed that family-specific environment either contributes to behavior problems only on an individual level, or that it has a lesser influence than originally thought.

Genetic and environmental variation in political orientation in adolescence and early adulthood: A Nuclear Twin Family analysis.

Political orientation is often assumed to be shaped by socialization processes; however, previous studies have shown substantial genetic variance components in party affiliation, political attitudes and behaviors, or closely related personality traits. The majority of these studies have relied on the Classical Twin Design, which comes with restrictive assumptions, some of which are easily violated. Moreover, most analyses lack a perspective of age-group differences. In this study, we investigated political orientation in adolescents (age: 16-18) and young adults (age: 21-25) in a cross-sectional Nuclear Twin Family Design. We used data of the German TwinLife project, including data from same-sex twins reared together, their biological parents, and nontwin full siblings. We found genetic variation in political orientation, which was significant in the older cohort, possibly indicating an increasing importance of active gene-environment correlation from adolescence to adulthood. Individual differences in political orientation because of passive gene-environment correlation and shared environmental effects were larger in the younger cohort, substantiating the same theoretical consideration and the importance of shared socialization contexts for adolescents' political views. By running Nuclear Twin Family model analyses, and considering age-group differences, as well as the relationship of political orientation with the Big Five personality traits, our study extended previous work, and resulted in more robust and fine-grained estimates of genetic and environmental sources of variance in political orientation. Therefore, it contributed to a better understanding of the complex nature-nurture interplay that forms political orientation in emerging adulthood. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

The healthy personality from a basic trait perspective.

What basic personality traits characterize the psychologically healthy individual? The purpose of this article was to address this question by generating an expert-consensus model of the healthy person in the context of the 30 facets (and 5 domains) of the Revised NEO Personality Inventory (Costa & McCrae, 1992) system of traits. In a first set of studies, we found that the healthy personality can be described, with a high level of agreement, in terms of the 30 facets of the NEO-PI-R. High levels of openness to feelings, positive emotions, and straightforwardness, together with low levels on facets of neuroticism, were particularly indicative of healthy personality functioning. The expert-generated healthy personality profile was negatively correlated with profiles of pathological personality functioning and positively correlated with normative personality functioning. In a second set of studies, we matched the NEO-PI-R profiles of over 3,000 individuals from 7 different samples with the expert-generated healthy prototype to yield a healthy personality index. This index was characterized by good retest reliability and cross-rater agreement, high rank-order stability, and substantial heritability. Individuals with high scores on the healthy personality index were psychologically well-adjusted, had high self-esteem, good self-regulatory skills, an optimistic outlook on the world, and a clear and stable self-view. These individuals were low in aggression and meanness, unlikely to exploit others, and were relatively immune to stress and self-sufficient. We discuss the results in the light of their implications for both research and theory on healthy personality functioning. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

The German Twin Family Panel (TwinLife).

The German Twin Family Panel (TwinLife) is a German longitudinal study of monozygotic and dizygotic same-sex twin pairs and their families that was designed to investigate the development of social inequalities over the life course. The study covers an observation period from approximately 2014 to 2023. The target population of the sample are reared-together twins of four different age cohorts that were born in 2009/2010 (cohort 1), in 2003/2004 (cohort 2), in 1997/1998 (cohort 3) and between 1990 and 1993 (cohort 4). In the first wave, the study included data on 4097 twin families. Families were recruited in all parts of Germany so that the sample comprises the whole range of the educational, occupational and income structure. As of 2019, two face-to-face, at-home interviews and two telephone interviews have been conducted. Data from the first home and telephone interviews are already available free of charge as a scientific use-file from the GESIS data archive. This report aims to provide an overview of the study sample and design as well as constructs that are unique in TwinLife in comparison with previous twin studies - such as an assessment of cognitive abilities or information based on the children's medical records and report cards. In addition, major findings based on the data already released are displayed, and future directions of the study are presented and discussed.

New evidence on the link between genes, psychological traits, and political engagement.

We investigate the link between genes, psychological traits, and political engagement using a new data set containing information on a large sample of young German twins. The TwinLife Study enables us to examine the predominant model of personality, the Big Five framework, as well as traits that fall outside the Big Five, such as cognitive ability, providing a more comprehensive understanding of the underpinnings of political engagement. Our results support previous work showing genetic overlap between some psychological traits and political engagement. More specifically, we find that cognitive ability and openness to experience are correlated with political engagement and that common genes can explain most of the relationship between these psychological traits and political engagement. Relationships between genes, psychological traits, and political engagement exist even at a fairly young age, which is an important finding given that previous work has relied heavily on older samples to study the link between genes, psychological traits, and political engagement.

The genetic and environmental effects on school grades in late childhood and adolescence.

As academic achievement can have a major impact on the development of social inequalities we set out to explore how performance differences arise. Using data of the German twin study TwinLife, genetic and environmental effects on school grades in mathematics, German and the grade point average in two age cohorts (11 and 17 years old) were identified. Structural equation modelling on the data of 432 monozygotic and 529 dizygotic twin pairs as well as 317 siblings of the twins showed substantial genetic effects (up to 62%) in both cohorts on all three variables. Next to genetic influences, the twin-specific environment as well as non-shared environmental influences were found to explain the interindividual differences in mathematics and German as well as the grade point average. A cohort effect showing itself in higher heritability in the older cohort was found for mathematics and the grade point average but not for German. Moreover, we compared twins who were assigned to the same classroom to those twins who were assigned to different classrooms and found lower effects of the twin-specific shared environment in the latter group. Our study thereby contributes to the understanding of the etiology of interindividual differences in academic achievement in the numeracy and literacy domain in two age cohorts.

Genetic and environmental influences on sociopolitical attitudes.

A new paradigm has emerged in which both genetic and environmental factors are cited as possible influences on sociopolitical attitudes. Despite the increasing acceptance of this paradigm, several aspects of the approach remain underdeveloped. Specifically, limitations arise from a reliance on a twins-only design, and all previous studies have used self-reports only. There are also questions about the extent to which existing findings generalize cross-culturally. To address those issues, this study examined individual differences in liberalism/conservatism in a German sample that included twins, their parents, and their spouses and incorporated both self- and peer reports. The self-report findings from this extended twin family design were largely consistent with previous research that used that rater perspective, but they provided higher estimates of heritability, shared parental environmental influences, assortative mating, and genotype-environment correlation than the results from peer reports. The implications of these findings for the measurement and understanding of sociopolitical attitudes are explored.

On the genetic and environmental sources of social and political participation in adolescence and early adulthood.

Political participation (POP), social participation (SOP), and political interest (PI) are important indicators of social status and social inequality. Previous studies on related trait differences yielded genetic and environmental contributions. However, focusing on adult samples, classical twin designs, and convenience samples often restricts parameter estimation and generalizability, and limits the understanding of age differences. We investigated sources of variance in POP, SOP, and PI in late adolescence and early adulthood with an extended twin family design (ETFD). We analyzed data from over 2,000 representative German twin families. Individual environments not shared by family members reflected the major source of variance for all variables, but genetic influences were also pronounced. Genetic effects were mostly higher for young adults, whereas effects of twins' shared environment were significant in adolescence. Our study deepens the understanding of the interplay between genetic and environmental factors in shaping differences in young persons' integration in society.

Genetic and Environmental Influences on Sociopolitical Attitudes: Addressing Some Gaps in the New Paradigm.

A new paradigm has emerged in which both genetic and environmental factors are cited as possible influences on sociopolitical attitudes. Despite the increasing acceptance of this paradigm, several aspects of the approach remain underdeveloped. Specifically, limitations arise from a reliance on a twins-only design, and all previous studies have used self-reports only. There are also questions about the extent to which existing findings generalize cross-culturally. To address those issues, this study examined individual differences in liberalism/conservatism in a German sample that included twins, their parents, and their spouses and incorporated both self- and peer reports. The self-report findings from this extended twin family design were largely consistent with previous research that used that rater perspective, but they provided higher estimates of heritability, shared parental environmental influences, assortative mating, and genotype-environment correlation than the results from peer reports. The implications of these findings for the measurement and understanding of sociopolitical attitudes are explored.

Personality traits below facets: The consensual validity, longitudinal stability, heritability, and utility of personality nuances.

It has been argued that facets do not represent the bottom of the personality hierarchy-even more specific personality characteristics, nuances, could be useful for describing and understanding individuals and their differences. Combining 2 samples of German twins, we assessed the consensual validity (correlations across different observers), rank-order stability, and heritability of nuances. Personality nuances were operationalized as the 240 items of the Revised NEO Personality Inventory (NEO-PI-R). Their attributes were examined by analyzing item residuals, controlling for the variance of the facet the item had been assigned to and all other facets. Most nuances demonstrated significant (p < .0002) cross-method agreement and rank-order stability. A substantial proportion of them (48% in self-reports, 20% in informant ratings, and 50% in combined ratings) demonstrated a significant (p < .0002) component of additive genetic variance, whereas evidence for environmental influences shared by twins was modest. Applying a procedure to estimate stability and heritability of true scores of item residuals yielded estimates comparable with those of higher-order personality traits, with median estimates of rank-order stability and heritability being .77 and .52, respectively. Few nuances demonstrated robust associations with age and gender, but many showed incremental, conceptually meaningful, and replicable (across methods and/or samples) predictive validity for a range of interest domains and body mass index. We argue that these narrow personality characteristics constitute a valid level of the personality hierarchy. They may be especially useful for providing a deep and contextualized description of the individual, but also for the prediction of specific outcomes. (PsycINFO Database Record

What Drives the Development of Social Inequality Over the Life Course? The German TwinLife Study.

The German twin family study 'TwinLife' was designed to enhance our understanding of the development of social inequalities over the life course. The interdisciplinary project investigates mechanisms of social inequalities across the lifespan by taking into account psychological as well as social mechanisms, and their genetic origin as well as the interaction and covariation between these factors. Main characteristics of the study are: (1) a multidimensional perspective on social inequalities, (2) the assessment of developmental trajectories in childhood, adolescence, and young adulthood in a longitudinal design by using (3) a combination of a multi-cohort cross-sequential and an extended twin family design, while (4) capturing a large variation of behavioral and environmental factors in a representative sample of about 4,000 German twin families. In the present article, we first introduce the theoretical and empirical background of the TwinLife study, and second, describe the design, content, and implementation of TwinLife. Since the data will be made available as scientific use file, we also illustrate research possibilities provided by this project to the scientific community.

The nature of creativity: The roles of genetic factors, personality traits, cognitive abilities, and environmental sources.

This multitrait multimethod twin study examined the structure and sources of individual differences in creativity. According to different theoretical and metrological perspectives, as well as suggestions based on previous research, we expected 2 aspects of individual differences, which can be described as perceived creativity and creative test performance. We hypothesized that perceived creativity, reflecting typical creative thinking and behavior, should be linked to specific personality traits, whereas test creativity, reflecting maximum task-related creative performance, should show specific associations with cognitive abilities. Moreover, we tested whether genetic variance in intelligence and personality traits account for the genetic component of creativity. Multiple-rater and multimethod data (self- and peer reports, observer ratings, and test scores) from 2 German twin studies-the Bielefeld Longitudinal Study of Adult Twins and the German Observational Study of Adult Twins-were analyzed. Confirmatory factor analyses yielded the expected 2 correlated aspects of creativity. Perceived creativity showed links to openness to experience and extraversion, whereas tested figural creativity was associated with intelligence and also with openness. Multivariate behavioral genetic analyses indicated that the heritability of tested figural creativity could be accounted for by the genetic component of intelligence and openness, whereas a substantial genetic component in perceived creativity could not be explained. A primary source of individual differences in creativity was due to environmental influences, even after controlling for random error and method variance. The findings are discussed in terms of the multifaceted nature and construct validity of creativity as an individual characteristic. (PsycINFO Database Record

The genetic and environmental roots of variance in negativity toward foreign nationals.

This study quantified genetic and environmental roots of variance in prejudice and discriminatory intent toward foreign nationals and examined potential mediators of these genetic influences: right-wing authoritarianism (RWA), social dominance orientation (SDO), and narrow-sense xenophobia (NSX). In line with the dual process motivational (DPM) model, we predicted that the two basic attitudinal and motivational orientations-RWA and SDO-would account for variance in out-group prejudice and discrimination. In line with other theories, we expected that NSX as an affective component would explain additional variance in out-group prejudice and discriminatory intent. Data from 1,397 individuals (incl. twins as well as their spouses) were analyzed. Univariate analyses of twins' and spouses' data yielded genetic (incl. contributions of assortative mating) and multiple environmental sources (i.e., social homogamy, spouse-specific, and individual-specific effects) of variance in negativity toward strangers. Multivariate analyses suggested an extension to the DPM model by including NSX in addition to RWA and SDO as predictor of prejudice and discrimination. RWA and NSX primarily mediated the genetic influences on the variance in prejudice and discriminatory intent toward foreign nationals. In sum, the findings provide the basis of a behavioral genetic framework integrating different scientific disciplines for the study of negativity toward out-groups.

Genetic and environmental sources of individual religiousness: the roles of individual personality traits and perceived environmental religiousness.

In the current study, we examined the genetic and environmental sources of the links between individual religiousness and individual personality traits, perceived parental religiousness, and perceived peer religiousness. Data from 870 individuals (incl. 394 twin pairs) were analyzed. Variance in individual religiousness was significantly influenced by genetic effects, environmental influences shared by twins reared together, and individual-specific environmental influences. Individual religiousness showed significant associations with age, sex, specific personality traits (e.g., agreeableness, openness to values), and perceived religiousness of important social interaction partners, such as parents, best friends, and spouses. The links to personality traits were relatively small and primarily genetically mediated. The associations between individual religiousness and parental religiousness were substantial and mediated by shared environmental effects. These links significantly decreased across age accompanying a significant decrease of shared environmental influences on individual religiousness. The correlations between individual religiousness and perceived religiousness of spouses and best friends were relatively moderate but increased with age. These associations were mediated by genetic as well as nonshared environmental sources accompanying an increase of nonshared environmental influences on individual religiousness with age. The results suggest that inter-individual differences in religiousness are due to multiple sources.