RESUMO
The study focused on Syzygium cumini Leaf Extract (SCLE) loaded into Carboxymethylcellulose (CMC) film via Solution casting. Phytochemical screening revealed carbohydrates, and HPLC analysis identified quercetin, known for promoting wound healing. FT-IR spectroscopy confirmed various functional groups. X-Ray diffraction (XRD) determined the crystallite size to be 14.58â¯nm. Field Emission Scanning Electron Microscopy (FESEM) showed the dispersion of extracts, and Energy Dispersive X-ray (EDX) analysis detailed the weight percentages of components. Antibacterial activity tests revealed zones of inhibition for S. aureus (15â¯mm) and E. coli (11â¯mm). The film exhibited 63.11â¯% antioxidant activity at 517â¯nm with DPPH at a 750⯵L sample concentration. Drug release kinetics were also studied. In-vitro wound healing using the L929 cell line showed 83â¯% healing at a 100⯵L concentration. Over 14â¯days, the treatment group's wounds healed completely within 7â¯days, unlike the control groups which showed no recovery after 14â¯days. These findings indicate that the SCLE-CMC film is highly effective in promoting wound healing.