1.
Bioorg Med Chem Lett
; 11(4): 443-5, 2001 Feb 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11229743
RESUMO
Certain alkaloids were observed to undergo N-demethylation processes under photochemical conditions. Tropine, acetyltropine, tropinone, and atropine were cleanly N-demethylated upon treatment with tetraphenylporphin, oxygen, and light. Dextromethorphan also underwent a N-demethylation reaction, but reacted further to afford an imine. In contrast, 14-acyloxycodeinones underwent a photochemically induced tandem N-demethylation acyl migration.