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J Agric Food Chem ; 66(22): 5531-5539, 2018 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-29546758

RESUMO

Pathogenic fungi continue to develop resistance against current antifungal drugs. To explore the potential of agricultural waste products as a source of novel antifungal compounds, we obtained an unbiased GC-MS profile of 151 compounds from 16 commercial and experimental cultivars of feijoa peels. Multivariate analysis correlated 93% of the compound profiles with antifungal bioactivities. Of the 18 compounds that significantly correlated with antifungal activity, 5 had not previously been described from feijoa. Two novel cultivars were the most bioactive, and the compound 4-cyclopentene-1,3-dione, detected in these cultivars, was potently antifungal (IC50 = 1-2 µM) against human-pathogenic Candida species. Haploinsufficiency and fluorescence microscopy analyses determined that the synthesis of chitin, a fungal-cell-wall polysaccharide, was the target of 4-cyclopentene-1,3-dione. This fungal-specific mechanism was consistent with a 22-70-fold reduction in antibacterial activity. Overall, we identified the agricultural waste product of specific cultivars of feijoa peels as a source of potential high-value antifungal compounds.


Assuntos
Antifúngicos/química , Antifúngicos/farmacologia , Quitina/biossíntese , Ciclopentanos/farmacologia , Feijoa/química , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Candida/efeitos dos fármacos , Candida/metabolismo , Parede Celular/efeitos dos fármacos , Parede Celular/metabolismo , Ciclopentanos/química , Feijoa/metabolismo , Testes de Sensibilidade Microbiana
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