Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Mais filtros










Intervalo de ano de publicação
1.
Lung Cancer ; 68(2): 234-9, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-19665818

RESUMO

PURPOSE: This study tested whether infliximab, a chimeric IgG1kappa monoclonal antibody that blocks tumor necrosis factor (TNF) alpha, improves/stabilizes weight loss in elderly and/or poor performance status patients with metastatic non-small cell lung cancer (NSCLC). METHODS: This double-blind trial randomly assigned patients to infliximab/docetaxel (n=32) versus placebo/docetaxel (n=29). The primary endpoint was > or = 10% weight gain. RESULTS: Groups were balanced with respect to age, number of prior chemotherapy regimens, baseline weight loss, and performance status. No patient gained > or = 10% baseline weight, and early evidence of the lack of efficacy prompted early trial closure. Appetite improvement was negligible in both arms. However, infliximab-/docetaxel-treated patients developed greater fatigue and worse global quality of life scores. Other outcomes, such as tumor response rate (<10% in both groups) and overall survival, were not statistically different between groups. There were no statistically significant differences in adverse events, although one death was attributed to infliximab. Genotyping for the TNF alpha -238 and -308 polymorphisms revealed no clinical significance of these genotypes, as relevant to the loss of weight or appetite. CONCLUSIONS: This trial closed early because infliximab did not prevent or palliate cancer-associated weight loss. Infliximab was associated with increased fatigue and inferior global quality of life.


Assuntos
Anticorpos Monoclonais/administração & dosagem , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/fisiopatologia , Neoplasias Pulmonares/tratamento farmacológico , Redução de Peso/efeitos dos fármacos , Idoso , Idoso de 80 Anos ou mais , Anticorpos Monoclonais/efeitos adversos , Docetaxel , Método Duplo-Cego , Fadiga/etiologia , Feminino , Estudos de Associação Genética , Genótipo , Humanos , Infliximab , Neoplasias Pulmonares/fisiopatologia , Masculino , Polimorfismo Genético , Qualidade de Vida , Taxoides/administração & dosagem , Taxoides/efeitos adversos , Fator de Necrose Tumoral alfa/genética , Fator de Necrose Tumoral alfa/imunologia
2.
JAMA ; 293(2): 162-3, 2005 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-15644540
3.
Buenos Aires; Reverte; 1956. 644 p. ilus.
Monografia em Espanhol | LILACS-Express | BINACIS | ID: biblio-1213380
4.
Buenos Aires; Reverte; 1956. 644 p. il. (109160).
Monografia em Espanhol | BINACIS | ID: bin-109160
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...