Pressure Mapping and Hemodynamic Assessment of Intracranial Dural Sinuses and Dural Arteriovenous Fistulas with 4D Flow MRI.

The feasibility of 4D flow MR imaging to visualize flow patterns and generate relative pressure maps in the dural venous sinus in healthy subjects (n = 60) and patients with dural arteriovenous fistulas (n = 7) was investigated. Dural venous drainage was classified based on torcular Herophili anatomy by using 4D flow MR imaging-derived angiograms and magnitude images. Subjects were scanned in a 3T clinical MR imaging system. 4D flow MR imaging enabled noninvasive characterization of dural sinus anatomy and mapping of relative pressure differences.

A unified perspective on the nature of bonding in pairwise interatomic interactions.

Different classes of ground electronic state pairwise interatomic interactions are referenced to a single canonical potential using explicit transformations. These approaches have been applied to diatomic molecules N2, CO, H2(+), H2, HF, LiH, Mg2, Ca2, O2, the argon dimer, and one-dimensional cuts through multidimensional potentials of OC-HBr, OC-HF, OC-HCCH, OC-HCN, OC-HCl, OC-HI, OC-BrCl, and OC-Cl2 using accurate semiempirically determined interatomic Rydberg-Klein-Rees (RKR) and morphed intermolecular potentials. Different bonding categories are represented in these systems, which vary from van der Waals, halogen bonding, and hydrogen bonding to strongly bound covalent molecules with binding energies covering 3 orders of magnitude from 84.5 to 89,600.6 cm(-1) in ground state dissociation energies. Such approaches were then utilized to give a unified perspective on the nature of bonding in the whole range of diatomic and intermolecular interactions investigated.

Recognizing hand movements from a single SEMG sensor using guided under-determined source signal separation.

Rehabilitation devices, prosthesis and human machine interfaces are among many applications for which surface electromyographic signals (sEMG) can be employed. Systems reliant on these muscle-generated electrical signals require various forms of machine learning algorithms for specific signature recognition. Those systems vary in terms of the signal detection methods, the feature selection and the classification algorithm used. However, in all those cases, the use of multiple sensors is a constant. In this paper, we present a new technique for source signal separation that relies on a single sEMG sensor. This proposed technique was employed in a classification framework for hand movements that achieved comparable results to other approaches in the literature, but yet, it relied on a much simpler classifier and used a very small number of features.

Erythro-1-(benzothiazol-2-yl)-1,2-dibromo-2-(2-chloro-5-nitrophenyl)ethane.

The title compound, C15H9Br2CIN2O2S, was synthesized by electrophilic addition of bromine to 2-(2-chloro-5-nitrostyryl)benzothiazole. The molecule consists of benzothiazole and 2-chloro-5-nitrophenyl rings linked by a 1,2-dibromoethane moiety. The dihedral angle between the benzothiazole and phenyl rings is 8.2(9) degrees. The benzothiazole ring is planar with a mean deviation of 0.168(7)A. The Br1--C8 and Br2--C9 bond distances are 1.972(5) and 2.007(6)A, respectively.

(E,Z)-2-(2-chloro-5-nitrostyryl)-1-(1-propenyl)benzimidazole.

The title compound, C18H14ClN3O2, was synthesized by the condensation of 2-chloro-5-nitrobenzaldehyde with 2-methyl-1-propenylbenzimidazole, and the molecule comprises a 2-chloro-5-nitrobenzene and a 1-(Z)-propenylbenzimidazole. The two aromatic moieties are conjugated through the vinyl group. The dihedral angle between the two rings is 1.4(6) degrees. The propenyl group lies out of the benzimidazole plane with a dihedral angle of 112.9(9) degrees.

Reductive activation of benzazolo[3,2-a]-quinolinium chlorides.

Initial ferricytochrome c (Cyt(III)c) reduction rates occurring in aerobic or anaerobic solutions containing either 3-nitrobenzothiazolo[3,2-a]-(NBQCl), 1-ethyl-3-nitrobenzimidazolo[3,2-a]-(ENBIQCl), 7-ethylbenzimidazolo[3,2-a]quinolinium chloride (EHBIQCL), or nitrofurantoin (NFT) and xanthine/xanthine oxidase were measured. Maximum rates in nitrogen-saturated solutions follow the order NFT > NBQCL > ENBIQCL > EHBIQCL. These rates correlate linearly with the half-wave reduction potentials (E1/2) of these compounds. With the exception of EHBIQCl, smaller rates of Cyt(III)c reduction were obtained in air-saturated than in nitrogen-saturated solutions at the quinolinium salt concentrations used. Larger concentrations of superoxide dismutase (SOD) are needed for 50% inhibition of the Cyt(III)c reduction reaction for heterocyclic compounds with larger E1/2 values. Thus, measurement of the portion of the Cyt(III)c reduction rate under air that is inhibited by SOD does not account solely for the production of superoxide. These observations suggest that NBQCL, ENBIQCl, and less probably EHBIQCl may interfere with mitochondrial energy metabolism or induce DNA damage through reduced intermediates.

Field evaluation of four biorational larvicide formulations against Anopheles albimanus in Honduras.

Four biorational larvicide formulations: Teknar (B.t.i.), Arosurf MSF (Monomolecular Surface Film), Arosurf MSF combined with Teknar, and SAN-809-I ([s]-methoprene combined with B.t.i.), were evaluated against naturally occurring populations of the malaria vector mosquito Anopheles albimanus Wiedemann in Honduras. All formulations reduced the mean number of larvae per sample area to 0 within 48 h after treatment, and gave significant (P less than 0.05) control when compared with similar untreated areas for at least 10 days after treatment. It is concluded that each of these four formulations can be used effectively to control the larvae of An. albimanus in Honduras.

Photochemistry of aqueous solutions of benzazolo[3,2-a]quinolinium salts. A spin-trapping study using 17O-enriched water and oxygen.

The photolysis of buffered aqueous solutions containing the quinolinium salts, 3-nitro-7-ethyl-benzimidazolo[3,2-a]quinolinium perchlorate (NEBQClO4) and 3-nitrobenzothiazolo[3,2-a]quinolinium chloride (NBQCl), at 344 and 365 nm, respectively, was studied in the presence of the spin trap 5,5-dimethyl-1-pyrroline-1-oxide (DMPO). Only a water-derived DMPO-OH.spin-adduct was obtained for both of these salts, at a DMPO concentration of 14 mM, as confirmed by H2 17O-enriched water experiments. A photosolvated intermediate is postulated as the OH donating species. Lower steady-state concentrations of the spin adduct were obtained in argon-saturated solutions, implying that oxygen gas is at least partially necessary in the water-derived DMPO-OH formation. Evidence for superoxide ion formation was obtained by the DMPO-17OH spin-adduct formation during the photolysis of NBQCl in an 17O-enriched oxygen atmosphere in the presence of 150 mM DMPO. An increase in the DMPO-OH steady-state concentration was observed if the photolysis of NBQCl was performed in the presence of superoxide dismutase (SOD). Our results suggest that this effect is due to the SOD inhibition of the destruction of DMPO-OH.by superoxide ion.

Charge transfer-oxy radical mechanism for anti-cancer agents.

The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm. Electrochemical studies were performed with some of the main types of agents: iminium ions (adenine iminium from alkylating species, iminium metabolite of 6-mercaptopurine, nitidine, other polynuclear iminiums) and metal complexes (Pt(II)diaquodiammine-guanosine, copper salicylaldoximes). Reduction potentials ranged from -0.4 to -1.2 V. Literature data for quinones are presented and radiation is discussed. Based on the theoretical framework, a rationale is offered for the carcinogen-anti-cancer paradox and the role of antioxidants.