RESUMO
Hasta el momento no se ha realizado ningún estudio específico sobre la historia de las farmacias en la ciudad de La Paz. Sin embargo existen algunos trabajos que dan datos de referencia para dirigir esta investigación, tales como el de Rolando Costa Arduz sobre la historia de los hospitales de la medicina por Juan Manuel Balcazar entre otros.
Assuntos
Farmácia/história , BolíviaRESUMO
The purpose of this study was to quantify the effect of the infiltration injection of different vasoconstrictor and anesthetic solutions on substance P (SP) expression in healthy human dental pulp. Thirty pulp samples were obtained from healthy upper premolars in which extraction was indicated for orthodontic reasons and were randomly assigned into three groups of 10 samples each: 2% lidocaine with 1:80,000 epinephrine (Lido group), 3% Prilocaine with 1:200000 felypressin (Prilo group); and 4% Prilocaine without vasoconstrictor (Prilo-no-VC group). All teeth were extracted 10 minutes after anesthetic application. Pulp samples were processed and SP was measured by radioimmunoassay. SP expression for the Lido, Prilo, and Prilo-no-VC groups were 616.49, 663.76, and 760.79 pmol/mg pulp tissue, respectively. Analysis of variance showed statistically significant differences between groups (p = 0.001). Tukey Honestly Significant Difference (HSD) post hoc tests showed significant statistical differences between the Prilo-no-VC group and the Lido group (p < 0.01) and between the Prilo-no-VC group and the Prilo group (p < 0.05). It can be concluded that infiltration injection of local anesthetics with vasoconstrictor attenuate SP expression in human dental pulp.
Assuntos
Anestésicos Locais/administração & dosagem , Polpa Dentária/efeitos dos fármacos , Neurotransmissores/análise , Substância P/efeitos dos fármacos , Vasoconstritores/administração & dosagem , Adolescente , Adulto , Polpa Dentária/irrigação sanguínea , Epinefrina/administração & dosagem , Felipressina/administração & dosagem , Humanos , Lidocaína/administração & dosagem , Microcirculação/efeitos dos fármacos , Prilocaína/administração & dosagem , Substância P/análise , Adulto JovemRESUMO
El uso racional de antimicrobianos requiere de un adecuado conocimiento del paciente y su contexto, sin embargo, también es importante tener un adecuado conocimiento sobre el mecanismo de acción de estos agentes, su preparación y administración especialmente parenteral y en el ambiente hospitalario y el conocimiento de sus efectos adversos. Esta revisión resume algunas consideraciones especiales relacionadas a la administración parenteral de antimicrobianos y sus principales efectos adversos.