Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
J Vet Med Sci ; 64(11): 1031-5, 2002 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-12499689

RESUMO

The protective capacity of the cotton rat, Sigmodon hispidus, against the migratory and intestinal phases of Strongyloides venezuelensis infection was examined. After subcutaneous infection with infective larvae (L(3)), adult worm recovery rates from male and female animals on Day 71 were only 0.10% and 0.06% of initial dose, respectively. To determine whether this enhanced protection was expressed during the migratory phase or the intestinal phase, larval recovery from the lungs of cotton rat was evaluated 3 days after subcutaneous L(3) infection. The larval recovery rate was only 0.5% of initial dose and about 40-fold lower than that from control mice. Protection in the intestine was also evaluated after intraduodenal implantation of adult worms. About 30% of implanted worms became established and worm burden remained constant until Day 28. Despite a high worm burden on Day 28, EPG was about 25-fold lower than the peak count. To evaluate expulsive capacity and monitor the cellular responses in the intestine of cotton rats, adult Nippostrongylus brasiliensis worms were implanted in addition to S. venezuelensis. Cotton rats were unable to expel adult S. venezuelensis worms, even after 21 days of observation. Although the number of mucosal mast cells increased significantly, the intraepithelial migration of mast cells was not observed. In contrast, N. brasiliensis was expelled by Day 6 in association with goblet cell hyperplasia. These results suggest that in cotton rats, the defective intestinal protection against adult S. venezuelensis worms results from dysfunction of mucosal mast cells.


Assuntos
Suscetibilidade a Doenças , Intestinos/parasitologia , Doenças dos Roedores/imunologia , Sigmodontinae/imunologia , Sigmodontinae/parasitologia , Strongyloides/fisiologia , Estrongiloidíase/imunologia , Animais , Feminino , Intestinos/imunologia , Larva/imunologia , Larva/fisiologia , Pulmão/parasitologia , Masculino , Mastócitos/imunologia , Nippostrongylus/imunologia , Nippostrongylus/fisiologia , Ratos , Doenças dos Roedores/parasitologia , Strongyloides/imunologia , Estrongiloidíase/veterinária , Fatores de Tempo
2.
J Vet Med Sci ; 64(6): 457-61, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12130827

RESUMO

The effects of male and female sex hormones on the protective capacity of Wistar rats against infection with Strongyloides venezuelensis were investigated. Male rats were more susceptible than females in terms of worm recovery from the lungs. Orchidectomy of male animals significantly reduced the plasma testosterone concentration and increased host resistance to the migratory stages of S. venezuelensis larvae. In contrast, ovariectomy of female animals significantly decreased host resistance in association with a significant reduction of estrogen levels. To examine the direct effect of sex hormones, exogenous testosterone and estrogen were implanted into animals. Susceptibility significantly increased or decreased in ovariectomized females given testosterone or estrogen, respectively. These results suggest that male and female sex hormones are important in the down- and up-regulation of host resistance against S. venezuelensis in Wistar rats.


Assuntos
Estrogênios/fisiologia , Pneumopatias Parasitárias/metabolismo , Strongyloides , Estrongiloidíase/parasitologia , Testosterona/fisiologia , Animais , Suscetibilidade a Doenças/metabolismo , Estrogênios/sangue , Feminino , Interações Hospedeiro-Parasita , Masculino , Orquiectomia , Ovariectomia , Ratos , Ratos Wistar , Fatores Sexuais , Testosterona/sangue
3.
J Vet Med Sci ; 64(6): 519-21, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12130838

RESUMO

The effects of host age and sex on susceptibility to Strongyloides venezuelensis in Wistar rats were examined by counting larvae recovered from the lungs of animals 3 days after infection. The susceptibility of female rats to S. venezuelensis rapidly decreased with age and elevated estrogen. Resistance in female rats inoculated at 6 and 10 weeks of age was nine and twenty-fold higher, respectively than that in the youngest group (3 weeks). In contrast, the susceptibility of male animals was lowest in the youngest group, then increased with age and elevated testosterone. Sex differences in susceptibility were not evident in the youngest group, but became apparent with age.


Assuntos
Pneumopatias Parasitárias/patologia , Strongyloides/crescimento & desenvolvimento , Estrongiloidíase/parasitologia , Fatores Etários , Animais , Suscetibilidade a Doenças , Feminino , Masculino , Ratos , Ratos Wistar , Fatores Sexuais
4.
J Vet Med Sci ; 64(5): 445-8, 2002 May.
Artigo em Inglês | MEDLINE | ID: mdl-12069079

RESUMO

Borna disease virus (BDV)-specific antibodies were monitored in Misaki feral horses annually for 4 years using an electrochemiluminescence immunoassay (ECLIA). Among 130 horses examined, 35 (26.9%) with an ECLIA count above 1000 once or more were judged as BDV seropositive. Throughout the study period, p24 antibodies were more frequent than p40 antibodies in almost all positive animals. Among the 35 seropositive horses, the ECLIA count was consistently high in 12 cases. Eleven horses seroconverted from negative to positive and 7 underwent reversal. The count in the remaining 95 horses (73.1%) remained low for 4 years and these animals were judged as seronegative.


Assuntos
Anticorpos Antivirais/análise , Doença de Borna/imunologia , Vírus da Doença de Borna/imunologia , Cavalos/imunologia , Cavalos/virologia , Envelhecimento , Animais , Anticorpos Antivirais/sangue , Eletroquímica/métodos , Feminino , Doenças dos Cavalos/imunologia , Doenças dos Cavalos/virologia , Cavalos/classificação , Imunoensaio/métodos , Japão , Medições Luminescentes , Masculino , Testes Sorológicos , Fatores de Tempo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...