RESUMO
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Assuntos
INFORME DE CASO , Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Exoftalmia , Exoftalmia/classificação , Exoftalmia/diagnósticoRESUMO
A case-control study of oral and pharyngeal cancer involving interviews with 108 cases and 286 controls was carried out in the University Hospital of Montevideo, Uruguay. The study was restricted to males and cases afflicted with lip, salivary gland and nasopharyngeal cancer were excluded. Point estimates of RR associated with smoking variables, alcohol variables, nutritional items and ingestion of hot infusions of the herb Ilex Paraguapensis (Mate) were obtained by logistic regression analysis. Dark tobacco smokers showed a RR 3.4 times higher than light tobacco users and heavy drinkers or wine displayed an OR of 17.2. Mate exposure showed a significant dose-response, after adjustement for age, tobacco and alcohol intake, with a fivefold increase in risk for heavy consumers. Joint exposure to black tobacco and wine displayed very high risks and no significant interactions were observed. The results suggest that the high rates of oropharyngeal cancer could be explained by the multiplicative effect of black tobacco smoking , wine drinking and mate ingestion (AU)
Assuntos
Humanos , Masculino , Neoplasias Orofaríngeas/etiologia , Neoplasias Bucais/etiologia , Neoplasias Faríngeas/etiologia , Tabagismo/efeitos adversos , Fatores de Risco , Vinho/efeitos adversos , Ilex paraguariensis/efeitos adversos , Consumo de Bebidas Alcoólicas/efeitos adversos , UruguaiRESUMO
One hundred seven patients afflicted with incident laryngeal cancer and 290 controls with diseases considered not related to tobacco and alcohol exposure were interviewed in the University Hospital of Montevideo, Uruguay. The study followed a case-referent design, and epidemiologic analysis was carried out at the Louisiana State University, New Orleans. Dark tobacco smoking was the strongest risk factor, with an RR 2.5 times higher than that showed by light (flue-cured) tobacco smokers and 35 times that of non-smokers. Alcohol exposure displayed lesser effects but its interaction with tobacco smoking resulted in very high risks (more than 100 times higher). Among particular types of alcoholic beverages, red wine showed RR's similar to those displayed by hard liquor consumption. The habit of drinking a local tea called mate was associated with a threefold increase in risk, after controlling for the effects of age and tobacco and alcohol consumption. Infrequent consumption of vegetables and fruits showed RR on the order of 2.7, suggesting a role of diet in the causation of laryngeal cancer (AU)
Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Idoso , Neoplasias Laríngeas/etiologia , Fatores de Risco , Tabagismo/efeitos adversos , Consumo de Bebidas Alcoólicas/efeitos adversos , Ilex paraguariensis/efeitos adversos , UruguaiRESUMO
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