Scleromyxedema in an adult following Sinopharm BBIBP-CorV vaccination: An extremely rare phenomenon.

Introduction: The Sinopharm BBIBP-CorV vaccine produces a variety of cutaneous adverse effects. Scleromyxedema is a mucinous connective tissue disorder that causes skin thickness and sclerodermoid changes. According to our findings, this is the first case of scleromyxedema induced by the Sinopharm immunization. Case description: We discuss the case of a 75-year-old woman who acquired progressive thickening of the skin in her limbs and trunk after getting the Sinopharm vaccination. Examination, laboratory testing, and a biopsy were used to verify scleromyxedema diagnosis. Intravenous immunoglobulins, mycophenolate mofetil, and prednisolone were used in the treatment of the patient. The outcomes from the 4-month follow-up were reassuring. Conclusion: This study emphasizes the need of considering scleromyxedema as a connective tissue pathology in patients who have recently received Sinopharm vaccine and have similar cutaneous signs.

Uncertainty analysis in probabilistic design of detention rockfill dams using Monte-Carlo simulation model and probabilistic frequency analysis of stability factors.

The detention rockfill dams are of promising importance in flood control projects, due to their minimal technical requirement, low cost, minimal environmental side effects, and self-automotive operation process. However, due to the complexity of Non-Darcian flow interactions with stability and uncertainties of dam, the reliable design is a challenging topic. This study aimed to examine the effects of uncertainties in probabilistic design of these dams. We proposed a reliable design framework for detention rockfill dams with a focus on the importance of stability analysis. The effects of design uncertainty sources on the stability of dam, safety factors of overturning, sliding and bearing, along with the hydraulic performance of the dam were examined. The results of the model revealed that the uncertainties in input parameters can effectively regenerate uncertainties in the hydraulic performance ranges from - 53.54 to + 110.11%. The safety factor against the sliding (SFS) has maximum dependencies with the uncertainties ranging - 32.63 to + 87.81%. The Monte-Carlo Simulation (MCS) and fitting probability distribution functions to the safety factor histograms, and uncertainty quantifications results in 88.3%in increasing the safety factors as a reliable methodology for stability design of detention rockfill dams. Thus, the study calls for reliable, certain, and safe design of flood protection rockfill ponds. The ecological evaluation and applying more advanced uncertainty assessment methods remains a future research direction of the current study. The developed framework can be used to acquire future detention rockfill dam design/modeling requirements for reliability-based design optimization as a simulation-optimization model coupled whit MCS.

Pure small cell neuroendocrine carcinoma of urinary bladder: A case report.

Small cell neuroendocrine carcinoma of the bladder is rare. We report a case of small cell carcinoma of the bladder with extensive regional lymph node metastases who underwent radical cystoprostatectomy and subsequent adjuvant systemic chemotherapy and chemoradiotherapy.