Multi-Site Pulse Transit Times, Beat-to-Beat Blood Pressure, and Isovolumic Contraction Time at Rest and Under Stressors.

This study investigates the beat-to-beat relationships among Pulse Transit Times (PTTs) and Pulse Arrival Times (PATs) concomitantly measured from the heart to finger, ear and forehead vascular districts, and their links with continuous finger blood pressure and isovolumic contraction time (IVCT). These aspects were explored in 22 young volunteers at rest and during cold pressure test (CPT, thermal stress), handgrip (HG, isometric exercise) and cyclo-ergometer pedalling (CYC, dynamic exercise). The starting point of the PTT measures was detected by the seismocardiogram. Results indicate that PTTs measured at the ear, forehead and finger districts are uncorrelated each other at rest, and during CPT and HG. The stressors produced district-dependent changes in the PTT variability. Only the dynamic exercise was able to induce significant changes with respect to rest in the PTTs mean values (-40%, -36% and -17%, respectively for PTTear, PTTfore, PTTfinger), and synchronize their modulations. Similar trends were observed in the PATs. IVCT decreased during the application of stressors with a minimum at CYC (-25%) reflecting an augmented heart contractility. The increase in blood pressure (BP) at CPT was greater than that at CYC (137 vs. 128 mmHg), but the correlations between beat-to-beat transit times and BP were maximal at CYC (PAT showed a higher correlation than PTT; correlations were greater for systolic than for diastolic BP). This suggests that pulse transit times do not always depend directly on the beat-to-beat BP values but, under specific conditions, on other factors and mechanisms that concomitantly also influence BP.

SeisMote: A Multi-Sensor Wireless Platform for Cardiovascular Monitoring in Laboratory, Daily Life, and Telemedicine.

This article presents a new wearable platform, SeisMote, for the monitoring of cardiovascular function in controlled conditions and daily life. It consists of a wireless network of sensorized nodes providing simultaneous multiple measures of electrocardiogram (ECG), acceleration, rotational velocity, and photoplethysmogram (PPG) from different body areas. A custom low-power transmission protocol was developed to allow the concomitant real-time monitoring of 32 signals (16 bit @200 Hz) from up to 12 nodes with a jitter in the among-node time synchronization lower than 0.2 ms. The BluetoothLE protocol may be used when only a single node is needed. Data can also be collected in the off-line mode. Seismocardiogram and pulse transit times can be derived from the collected data to obtain additional information on cardiac mechanics and vascular characteristics. The employment of the system in the field showed recordings without data gaps caused by transmission errors, and the duration of each battery charge exceeded 16 h. The system is currently used to investigate strategies of hemodynamic regulation in different vascular districts (through a multisite assessment of ECG and PPG) and to study the propagation of precordial vibrations along the thorax. The single-node version is presently exploited to monitor cardiac patients during telerehabilitation.