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Biomol NMR Assign ; 17(2): 183-188, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37421542

RESUMO

The N-acyl-L-homoserine lactone (AHL) quorum sensing regulates virulence in the opportunistic pathogen, Pseudomonas aeruginosa. The LasI and RhlI AHL synthases use acyl carrier protein substrates to synthesize, respectively, the 3-oxododecanoyl-L-homoserine lactone (3-oxoC12-HSL) and butyryl-L-homoserine lactone (C4-HSL) QS signals for this bacterium. Although P. aeruginosa genome contains three open reading frames to encode three acyl carrier proteins, namely the ACP1, ACP2 and ACP3, microarray and gene replacement studies show that only the ACP1 carrier protein is under quorum sensing regulation. In this study, we isotopically enriched one of the acyl carrier proteins, ACP1 from P. aeruginosa and describe the backbone resonance assignments for this protein to delineate the structural and molecular basis of ACP1 recognition in P. aeruginosa AHL quorum sensing signal synthesis.


Assuntos
Proteína de Transporte de Acila , Pseudomonas aeruginosa , Pseudomonas aeruginosa/metabolismo , Proteína de Transporte de Acila/metabolismo , Ressonância Magnética Nuclear Biomolecular , Percepção de Quorum , Acil-Butirolactonas/metabolismo , Proteínas de Bactérias/metabolismo
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