RESUMO
INTRODUCTION: We looked at the association between Terry nails and liver cirrhosis in an ambulatory population from hepatology and gastroenterology clinics. METHODS: We prospectively investigated the prevalence and determinants of Terry nails in 1,000 consecutive patients from hepatology and gastroenterology clinics at 2 institutions between May 2016 and February 2020. RESULTS: A total of 117 subjects manifested Terry nails, with a 25.6% prevalence in patients with cirrhosis. When adjusted for age, heart failure, diabetes mellitus type 2, and chronic liver disease, cirrhosis was the only significant correlate (odds ratio 5.7 [95% confidence interval 3.3-9.8]), irrespective of liver disease etiology, with a strong association with hepatic fibrosis stage (P < 0.0001). DISCUSSION: Sensitivity and specificity of Terry nails for cirrhosis (25.8%, 92.7%) was similar to palmar erythema but less than spider angioma.
Assuntos
Cirrose Hepática/complicações , Doenças da Unha/etiologia , Unhas/patologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Unha/diagnóstico , Doenças da Unha/epidemiologia , Prevalência , Estudos Prospectivos , Estados Unidos/epidemiologiaAssuntos
Doença Hepática Terminal/complicações , Doenças da Vesícula Biliar/diagnóstico , Infecções por Klebsiella/diagnóstico , Klebsiella oxytoca/isolamento & purificação , Abscesso Hepático/diagnóstico , Cirrose Hepática/complicações , Colecistite/complicações , Colecistite/diagnóstico , Doenças da Vesícula Biliar/complicações , Cálculos Biliares/complicações , Cálculos Biliares/diagnóstico , Humanos , Infecções por Klebsiella/etiologia , Abscesso Hepático/etiologia , Masculino , Pessoa de Meia-IdadeAssuntos
Anticorpos Monoclonais/efeitos adversos , Antineoplásicos/efeitos adversos , Colite/induzido quimicamente , Fatores Imunológicos/efeitos adversos , Idoso , Colite/tratamento farmacológico , Colite/imunologia , Diarreia/induzido quimicamente , Diarreia/tratamento farmacológico , Diarreia/imunologia , Humanos , Ipilimumab , Masculino , Melanoma/tratamento farmacológico , Neoplasias da Coluna Vertebral/tratamento farmacológicoRESUMO
Adenoviral-mediated overexpression of the intracellular superoxide (O(2)(*-)) scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD) in the brain attenuates central angiotensin II (AngII)-induced cardiovascular responses. However, the therapeutic potential for adenoviral vectors is weakened by toxicity and the inability of adenoviral vectors to target the brain following peripheral administration. Therefore, we developed a non-viral delivery system in which CuZnSOD protein is electrostatically bound to a synthetic poly(ethyleneimine)-poly(ethyleneglycol) (PEI-PEG) polymer to form a polyion complex (CuZnSOD nanozyme). We hypothesized that PEI-PEG polymer increases transport of functional CuZnSOD to neurons, which inhibits AngII intra-neuronal signaling. The AngII-induced increase in O(2)(*-), as measured by dihydroethidium fluorescence and electron paramagnetic resonance spectroscopy, was significantly inhibited in CuZnSOD nanozyme-treated neurons compared to free CuZnSOD- and non-treated neurons. CuZnSOD nanozyme also attenuated the AngII-induced inhibition of K(+) current in neurons. Intracarotid injection of CuZnSOD nanozyme into rabbits significantly inhibited the pressor response of intracerebroventricular-delivered AngII; however, intracarotid injection of free CuZnSOD or PEI-PEG polymer alone failed to inhibit this response. Importantly, neither the PEI-PEG polymer alone nor the CuZnSOD nanozyme induced neuronal toxicity. These findings indicate that CuZnSOD nanozyme inhibits AngII intra-neuronal signaling in vitro and in vivo.
