RESUMO
The 2022 Annual Joint Meeting (AJM) and Young Investigators' Forum of the Canadian Society for Clinical Investigation / Société Canadienne de recherches clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada/Association des cliniciens-chercheurs en formation du Canada (CITAC/ACCFC) was held in Montréal, November 13-14, 2022. The theme of this year's AJM was "Strength in Perseverance" and focused on highlighting clinician-investigator trainee achievements and resilience in research engagement through recent challenging and unprecedented times. The opening remarks were given by Nicola Jones (president of CSCI/SCRC) and Heather Whittaker (past president of CITAC/ACCFC). The keynote speaker was Dr. Michael Strong, who delivered the presentation "The Future of Clinician Scientists in Canada." Dr. Caroline Quach (Université de Montréal) received the CSCI Distinguished Scientist Award and Dr. Amy Metcalfe (University of Calgary) received the CSCI Joe Doupe Young Investigator Award. Each of the clinician-scientists delivered presentations on their award-winning research. The four interactive workshops included "Social Media in Science and Medicine," "Diversity in Science and Medicine," "Running a Successful Research Program," and "Mentorship in Action." The AJM also included presentations from clinician investigator trainees from across the country. Over 90 abstracts were showcased at this year's meeting, most of which are summarized in this review. Six outstanding abstracts were selected for oral presentations during the President's Forum.
RESUMO
Background: COVID-19 is caused by SARS-CoV-2 and has a wide range of symptoms. While Diabetes Mellitus (DM) is a common comorbidity in COVID-19 patients, it is the main comorbidity in non-surviving COVID-19 patients. Interleukin-8 (IL-8) is a cytokine that has been correlated with severity and mortality in COVID-19 patients, but its role in COVID-19 patients with DM comorbidity and its relationship with NLR and CRP as markers of inflammation are not yet fully understood. Objective: To investigate the correlation between IL-8, NLR, and CRP in COVID-19 patients with DM comorbidity. Methods: A cross-sectional study was conducted at the Integrated Infectious Disease Installation of Dr. Saiful Anwar Malang Hospital from June to November 2021 using consecutive sampling. IL-8 was measured using the ELISA method with Legendmax® Human IL-8. NLR was measured using flow cytometry, while CRP was measured using the immunoturbidimetric method with Cobas C6000®. Patient outcomes were obtained from medical records. Results: A total of 124 research subjects participated in the study. IL-8 and CRP levels were significantly higher (p < 0.05) in COVID-19 patients with DM comorbidity, and were also significantly higher (p < 0.05) in non-surviving COVID-19 patients. Overall, there was a positive correlation between IL-8 and CRP (r = 0.58, p < 0.05). There was also a positive correlation between IL-8 (r = 0.58; p < 0.05), NLR (r = 0.45, p < 0.05), CRP (r = 0.54, p < 0.05) and mortality in COVID-19 patients with DM comorbidity. The presence of DM comorbidity increased IL-8 levels and aggravated inflammation in COVID-19 patients, thereby increasing the risk of mortality. Conclusion: IL-8, CRP and NLR levels were higher in non-surviving COVID-19 patients with DM comorbidity, indicating that they could serve as good predictors of poor outcomes in this patient population.
RESUMO
Se realiza un estudio a 60 pacientes del servicio de nefrología del Hospital Infantil Norte, de Santiago de Cuba, con el diagnóstico de glomerulonefritis difusa aguda post estreptococcica en el período comprendido de julio a diciembre de 1994.Se realizó un estudio de tipo descriptivo con corte transversal cuyo universo lo constituyeron todos los pacientes ingresados en el servicio de nefrología en dicho período con este diagnóstico; el dato primario se obtuvo de las historias clínicas de cada caso.De tal de pacientes pacientes analizados se determinó que esta enfermedad es más frecuente en la edad escolar y procedentes de área rural, que el foco primario que predominó fue la Piodermitis.La hematuria estuvo presente en todos los casos, elemento que orienta el diagnóstico de esta enfermedad, encontramos que tanto el eritrosedimentación como el antiestroptolisina o se encuentran alterados en todos y aunque la totalidad no se utilizó antibioticos, la evolución fue satisfactoria en 100 por ciento de los casos
Assuntos
Humanos , Criança , GlomerulonefriteRESUMO
Se realiza un estudio a 60 pacientes del servicio de nefrología del Hospital Infantil Norte, de Santiago de Cuba, con el diagnóstico de glomerulonefritis difusa aguda post estreptococcica en el período comprendido de julio a diciembre de 1994.Se realizó un estudio de tipo descriptivo con corte transversal cuyo universo lo constituyeron todos los pacientes ingresados en el servicio de nefrología en dicho período con este diagnóstico; el dato primario se obtuvo de las historias clínicas de cada caso.De tal de pacientes pacientes analizados se determinó que esta enfermedad es más frecuente en la edad escolar y procedentes de área rural, que el foco primario que predominó fue la Piodermitis.La hematuria estuvo presente en todos los casos, elemento que orienta el diagnóstico de esta enfermedad, encontramos que tanto el eritrosedimentación como el antiestroptolisina o se encuentran alterados en todos y aunque la totalidad no se utilizó antibioticos, la evolución fue satisfactoria en 100 por ciento de los casos
