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1.
J Clin Med ; 12(23)2023 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-38068468

RESUMO

BACKGROUND: Shoulder pain is a disabling musculoskeletal disorder worldwide. Thus, it is important to identify interventions able to improve pain and disability. OBJECTIVE: To investigate the effects of mobilization with movement (MWM) on pain, disability, and range of motion in patients with shoulder pain and movement impairment. METHODS: A systematic search of different databases was performed. The systematic review protocol has been registered in PROSPERO (CRD42023404128). A random-effects model for meta-analysis was used to determine the mean difference (MD), standardized mean differences (SMD), and 95% confidence interval for the outcome of interest. RESULTS: Twenty-six studies were included. Of these, eighteen were included in the meta-analysis. MWM improved pain during movement with a moderate effect SMD of (-0.6; 95% confidence interval, -1.1 to -0.1, I2 = 0%; N = 66;) and shoulder abduction MD of (12.7°; 1.3 to 24.0; I2 = 73%; N = 90) compared to sham MWM in the short term (0-6 weeks). Combined MWM and conventional rehabilitation improved pain at rest, with a MD of (-1.2; -2.2 to -0.2; I2 = 61%; N = 100), and disability SMD of (-1.3; confidence interval -2.2 to -0.4; I2 = 87%; N = 185) compared to conventional rehabilitation alone in the short term. Combined MWM and conventional rehabilitation also resulted in improvement in shoulder abduction and external rotation. Compared to Maitland, MWM resulted in improvement in the shoulder abduction MD (20.4°; confidence interval 4.3 to 36.5; I2 = 89%; N = 130) in the short term. There is no information regarding long-term effects. CONCLUSION: Evidence suggests that MWM may reduce shoulder pain and restore shoulder range of motion and function. Our findings are promising, but the evidence is not strong enough to recommend it pragmatically.

2.
Polymers (Basel) ; 15(18)2023 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-37765536

RESUMO

The development of wind turbines for regions with low wind speeds imposes a challenge to the expansion of the corresponding energy generation capacity. The present work consists of an evaluation of the potential carded jute fiber and jute yarn to be used in the construction of a wind blade for regions of low wind intensity. The fibers used were supplied by Company Textile of Castanhal (Castanhal-Para-Brazil) and used in the study without chemical treatment in the form of single-filament fibers and yarns with a surface twist of 18.5°. The composites were produced through the resin infusion technique and underwent tensile and shear tests using 120-Ohm strain gauges and a blade extensometer to obtain the Young's modulus. In the analysis of the results, the ANOVA test was applied with a 0.05 significance level, followed by Tukey's test. The results showed that long, aligned jute fibers can be a good option for laminated structures applied in composites for small wind turbine blades.

3.
Contemp Clin Trials ; 127: 107138, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36868348

RESUMO

Obesity is one of the major public health problems of the 21st century, affecting every country in the world. In Mexico, the prevalence of overweight and obesity in children (5 to 11 years) was 35.5%. Childhood obesity is a chronic disease itself; and is associated with other chronic conditions. OBJECTIVE: To assess the effect and feasibility of a participatory intervention to improve nutrition and physical activity within the school environment in children in public elementary schools in Mexico. METHODS: The present study is a cluster trial. The intervention focused on; changes in food offered, training the schools' food service staff, promoting water consumption and physical activity at the community level, implementing healthy spaces inside the school, improving the quality of physical education within schools, among others. The main outcomes will focus on rate of weight gain, time devoted to physical activity, sedentary behaviors, diet quality and response feeding behaviors. We also will assess the time and personnel involved in the intervention development, maintenance, and dissemination. CONCLUSION: Findings from this trial will generate new translational knowledge in Mexico; if the results are positive, this participatory intervention could serve as a basis for designing multidimensional interventions that could be scaled up at the national level.


Assuntos
Obesidade Infantil , Criança , Humanos , Dieta , Exercício Físico , Promoção da Saúde/métodos , México/epidemiologia , Obesidade Infantil/epidemiologia , Obesidade Infantil/prevenção & controle , Serviços de Saúde Escolar , Instituições Acadêmicas
4.
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1529124

RESUMO

ABSTRACT Objective: To determine the level of scientific information of dental surgeons who carry out their professional activities in Brazil about antiresorptive drugs and indicated pharmacological procedures aiming at the prevention of osteonecrosis of the jaws and the therapy of drug sequelae that may occur, considering the time since graduation in Dentistry. Material and Methods: This is a quantitative cross-sectional study in which 339 dentists were consulted using the virtual questionnaire containing topics of personal nature, elements contained in the anamnesis carried out and knowledge about antiresorptive drugs, including indications, adverse effects and treatments applied. Chi-square and Fisher's exact tests were performed to analyze associations of data described by absolute and relative frequencies with professionals' time since graduation. All analyses were performed using the R software, with a 5% significance level. Results: Those who revealed to have graduated for more than five years with the highest academic degree were those who demonstrated maximum knowledge of antiresorptive drugs or revealed that, somehow, they had information about them (p<0.05). Conclusion: Dental surgeons in Brazil who have more than five years since graduation have more scientific information about antiresorptive drugs and pharmacological procedures, which can positively contribute to the prevention of osteonecrosis of the jaws and treatment of drug sequelae that may occur.


Assuntos
Humanos , Masculino , Feminino , Adulto , Difosfonatos/farmacologia , Conservadores da Densidade Óssea , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos , Distribuição de Qui-Quadrado , Estudos Transversais/métodos
5.
Polymers (Basel) ; 14(3)2022 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-35160392

RESUMO

Mechanical properties of composites reinforced with lignocellulosic fibers have been researched in recent decades. Jute and mallow fibers are reinforcement alternatives, as they can contribute to increase the mechanical strength of composite materials. The present work aims to predict the Young's modulus with application of continuous and aligned lignocellulosic fibers to be applied as reinforcement in polyester matrix. Fibers were manually separated and then arranged and aligned in the polyester matrix. Composites with addition 5, 15, and 25 vol% jute and mallow fibers were produced by vacuum-assisted hand lay-up/vaccum-bagging procedure. Samples were tested in tensile and the tensile strength, elasticity modulus, and deformation were determined. Results showed that the intrinsic Young's modulus of the fibers was set at values around 17.95 and 11.72 GPa for jute and mallow fibers, respectively. Statistical analysis showed that composites reinforced with 15 and 25 vol% jute and mallow presented the highest values of tensile strength and Young's modulus. The incorporation of 25 vol% of jute and mallow fibers increased the matrix Young's modulus by 534% and 353%, respectively, effectively stiffening the composite material. Prediction models presented similar values for the Young's modulus, showing that jute and mallow fibers might be used as potential reinforcement of polymeric matrices.

6.
Curr Rheumatol Rev ; 18(4): 352-356, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34784875

RESUMO

AIMS: To study the clinical and laboratory findings between patients with primary Antiphospholipid Syndrome (pAPS) with and without LR. BACKGROUND: Livedo Reticularis (LR) is a common manifestation of Antiphospholipid Syndrome (APS). Although no previous study evaluated patients with and without LR. METHODS: A transversal study including 66 pAPS patients was performed. Demographical, anthropometric, medication use, antiphospholipid antibodies profile data were evaluated, and LR's clinical and laboratory features. Patients were subdivided into one of two groups: pAPS with LR and pAPS without LR. RESULTS: Both groups were alike concerning demographics and anthropometrics. Interestingly, the frequency of stroke (28.5 vs. 7.5%, p=0.04), as well as of Sneddon's syndrome (100 vs. 30.0%, p<0.0001), were higher in pAPS with LR than the other group. Conversely, patients in the pAPS without LR group had more thyroidopathy than those in the pAPS with LR group (80% vs. 50% %, p=0.03). CONCLUSION: Patients with pAPS and LR have more stroke and seem to be protected from thyroidopathy. Careful follow-up of these patients is therefore advised.


Assuntos
Síndrome Antifosfolipídica , Livedo Reticular , Acidente Vascular Cerebral , Doenças da Glândula Tireoide , Humanos , Feminino , Síndrome Antifosfolipídica/complicações , Livedo Reticular/complicações , Anticorpos Antifosfolipídeos , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/complicações , Doenças da Glândula Tireoide/complicações
7.
BMC Complement Med Ther ; 21(1): 286, 2021 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-34814913

RESUMO

BACKGROUND: Oral candidiasis is an opportunistic disease caused by fungi of the Candida genus. The occurrence of Candida spp. resistance to the commercial antifungal drugs points to the search for alternative treatments. Propolis has been successfully used in the treatment of infectious diseases for centuries. It has been proposed that an ultrasound pretreatment in the propolis extraction protocol can enhance the concentrations of molecules with antimicrobial activities in the final extract. Thus, this study aimed to compare the antifungal activity against oral Candida spp. isolates of green and red propolis extracts submitted or not to an ultrasound pretreatment before the extraction procedure. METHODS: Candida spp. were isolated from denture stomatitis lesions and identified by sequencing. Oral Candida spp. isolates and reference strains were submitted to broth microdilution assays using commercial antifungals and Brazilian green and red propolis extracts submitted or not to an ultrasound pretreatment. Minimal Inhibitory Concentrations (MIC) and Minimal Fungicide Concentrations (MFC) were determined and biofilm formation interference was evaluated for resistant isolates. RESULTS: C. albicans, Candida tropicalis and Candida dubliniensis were isolated from denture stomatitis lesions. Growth inhibition was observed in all Candida isolates incubated with all green and red propolis extracts. At lower doses, red propolis extracts presented significant antifungal activity. The ultrasound pretreatment did not promote an increase in the antifungal activity of green or red propolis. Three isolates, which were highly resistant to fluconazole and itraconazole, were susceptible to low doses of red propolis extracts. These same three specimens had their biofilm formation inhibted by red propolis ethanolic extract. CONCLUSIONS: Thus, red propolis can be faced as a promising natural product to be used in the auxiliary antifungal therapy of denture stomatitis.


Assuntos
Antifúngicos/farmacologia , Candidíase Bucal/tratamento farmacológico , Extratos Vegetais/farmacologia , Própole/farmacologia , Estomatite sob Prótese/tratamento farmacológico , Fluconazol/farmacologia , Humanos , Itraconazol/farmacologia , Cetoconazol/farmacologia , Testes de Sensibilidade Microbiana
9.
Codas ; 33(4): e20190266, 2021.
Artigo em Português, Inglês | MEDLINE | ID: mdl-34259779

RESUMO

PURPOSE: To describe the performance of elderly individuals in Pitch Pattern Sequence (PPS) and Duration Pattern Sequence (DPS) tests and research related factors. METHODS: An observational, cross-sectional study conducted with elderly people aged 60 to 79 years. The participants underwent cognitive screening tests, interviews containing socio-demographic data and general health, as well as audiologic evaluation and temporal auditory processing (PPS and DPS) evaluation tests. A descriptive analysis of the association between the performance in temporal processing and the variables gender, age, level of education and audiometric alterations was conducted through multiple linear regression. RESULTS: 86 elderly people participated in the study, most of them female, with ages between 60 and 69. Male participants performed better in both tests as well as the participants with higher education, whereas no difference in performance was observed across the different age ranges. In the DPS, the participants with auditory alteration performed worse in relation to the ones with average frequencies of 0.5 to 4 kHz. CONCLUSION: The male gender and higher level of education were associated with better results in the temporal ordering tests, whereas auditory alteration was associated with worse performance only in the pitch pattern sequence test.


OBJETIVO: Investigar os fatores associados e descrever o desempenho no teste padrão de frequência e teste padrão de duração em idosos. MÉTODO: Estudo observacional, seccional, conduzido com idosos de 60 a 79 anos. Os participantes realizaram teste de rastreio cognitivo, entrevista contendo dados sociodemográficos e de saúde geral, avaliação audiológica e testes de avaliação do processamento auditivo temporal (padrão de frequência e padrão de duração). Foi conduzida análise descritiva da associação entre o desempenho nos testes de processamento temporal e as variáveis: sexo, idade, nível de escolaridade e alterações audiométricas, por meio da regressão linear múltipla. RESULTADOS: Participaram do estudo 86 idosos, sendo a maioria do sexo feminino, com idade entre 60 e 69 anos. O desempenho para ambos os testes foi melhor nos homens e nos idosos com maior nível de escolaridade e similar nas diferentes faixas etárias. No teste padrão de frequência, idosos com alteração auditiva apresentaram pior desempenho do que aqueles com média nas frequências de 0.5 a 4 kHz normal. CONCLUSÃO: O sexo masculino e maior nível de escolaridade estão associados ao melhor desempenho nos testes de ordenação temporal, enquanto a alteração audiométrica apresenta associação com o pior desempenho apenas no teste padrão de frequência.


Assuntos
Testes Auditivos , Percepção do Tempo , Idoso , Audiometria , Percepção Auditiva , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
10.
Rheumatol Ther ; 8(3): 1255-1261, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34228316

RESUMO

INTRODUCTION: The aim of this study was to investigate the frequency of avascular necrosis (AVN) and its associations with clinical and laboratory parameters in patients with primary antiphospholipid antibody syndrome (pAPS). METHODS: This was a cross-sectional study of 66 patients with pAPS who fulfilled the Sidney criteria for APS. Epidemiological and clinical data, and data on antiphospholipid antibodies were collected. Diagnosis of AVN was based on studies of magnetic resonance (MRI) images of affected bones. RESULTS: AVN was found in three of the 66 (4.5%) enrolled patients. Comparison of patients with pAPS with and without AVN showed that demographic data, comorbidities, and antiphospholipid antibodies profile were similar in both groups. Compared to patients without AVN, those with AVN had thrombocytopenia more frequently (66.7 vs. 7.9%) and used more glucocorticoids (100 vs. 35%). CONCLUSION: AVN is rare in patients with pAPS and may be associated with thrombocytopenia and previous glucocorticoid use.

11.
Biomed Phys Eng Express ; 7(5)2021 08 06.
Artigo em Inglês | MEDLINE | ID: mdl-34320475

RESUMO

In order to provide favorable conditions for bone regeneration, a lot of biomaterials have been developed and evaluated, worldwide. Composite biomaterials have gained notoriety, as they combine desirable properties of each isolated material. Thus, in this research, bone repair capacity of three developed formulations of ceramic scaffolds were evaluated histomorphometrically, after implantation. Scaffolds were based on wollastonite (W) andß-tricalcium phosphate (ß-TCP) composites in three different ratios (wt.%). ThirtyWistarrats were randomly assigned to three experimental groups: W-20 (20 W/80ß-TCP wt.%), W-60 (60 W/40ß-TCP wt.%), and W-80 (80 W/20ß-TCP wt.%), evaluated by optical microscopy at biological tests after 15 and 45 days of implantation. Throughout the study, the histological results evidenced that the scaffolds remained at the implantation site, were biocompatible and presented osteogenic potential. The percentage of neoformed mineralized tissue was more evident in the W-20 group (51%), at 45 days. The composite of the W-80 group showed more evident biodegradation than the biomaterials of the W-20 and W-60 groups. Thus, it is concluded that the scaffold containing 20 W/80ß-TCP (wt.%) promoted more evident bone formation, but all composites evaluated in this study showed notorious bioactivity and promising characteristics for clinical application.


Assuntos
Regeneração Óssea , Crânio , Alicerces Teciduais , Animais , Materiais Biocompatíveis , Compostos de Cálcio , Fosfatos de Cálcio , Ratos , Silicatos , Crânio/diagnóstico por imagem
12.
Iran Endod J ; 16(4): 217-224, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-36704778

RESUMO

Introduction: Flat-oval root canals of incisors can be problematic in retreatments. This study assessed the efficacy of continuous and reciprocating rotation instruments in retreatment of flat-oval root canals in lower incisors via micro-computed tomography (micro-CT). File systems studied were ProTaper universal retreatment rotary system associated with ProTaper Next (PTUR+PTN), D-RaCe associated with iRaCe (DR+iR), Reciproc (REC), and WaveOne (WO). Materials and Methods: Thirty-two mandibular incisors with flat root canal were divided into 4 groups (n=8). The groups were initially prepared with PTN, iRaCe, REC, and WO, then instrumented, filled, and subjected to micro-CT analyses. All the canals were then retreated with the PTUR+PTN, DR+iR, REC, and WO, and then subjected to new micro-CT analysis which allowed quantification of residual filling material volume and change in the diameter of the root canal apical third. Endodontic retreatment time was also quantified. Data were analyzed with One-Way ANOVA and post hoc t tests. Results: None of the systems completely removed the filling material. The groups differed in terms of remnant filling material volume (PTUR+PTN=2.9±1.1 mm3; DR+iR=3.6±3.1 mm3; REC=4.9±1.9 mm3; WO=3.1±1.9 mm3) and retreatment time (PTUR+PTN=1:36±0:12 sec; DR+iR=0:57±0:13 sec; REC=2:10±0:44 sec; WO=2:03±0:31 sec), but had similar values in terms of change in apical root canal diameter (P>0.05). Conclusions: Based on this in vitro study, the type of endodontic instrument did not affect the diameter of the root canal apical third. However, PTUR with ProTaper Next had the lowest residual filling material volume and second lowest retreatment time, in flat-oval root canals in mandibular incisors.

13.
CoDAS ; 33(4): e20190266, 2021. tab, graf
Artigo em Português | LILACS | ID: biblio-1286106

RESUMO

RESUMO Objetivo Investigar os fatores associados e descrever o desempenho no teste padrão de frequência e teste padrão de duração em idosos. Método Estudo observacional, seccional, conduzido com idosos de 60 a 79 anos. Os participantes realizaram teste de rastreio cognitivo, entrevista contendo dados sociodemográficos e de saúde geral, avaliação audiológica e testes de avaliação do processamento auditivo temporal (padrão de frequência e padrão de duração). Foi conduzida análise descritiva da associação entre o desempenho nos testes de processamento temporal e as variáveis: sexo, idade, nível de escolaridade e alterações audiométricas, por meio da regressão linear múltipla. Resultados Participaram do estudo 86 idosos, sendo a maioria do sexo feminino, com idade entre 60 e 69 anos. O desempenho para ambos os testes foi melhor nos homens e nos idosos com maior nível de escolaridade e similar nas diferentes faixas etárias. No teste padrão de frequência, idosos com alteração auditiva apresentaram pior desempenho do que aqueles com média nas frequências de 0.5 a 4 kHz normal. Conclusão O sexo masculino e maior nível de escolaridade estão associados ao melhor desempenho nos testes de ordenação temporal, enquanto a alteração audiométrica apresenta associação com o pior desempenho apenas no teste padrão de frequência.


ABSTRACT Purpose To describe the performance of elderly individuals in Pitch Pattern Sequence (PPS) and Duration Pattern Sequence (DPS) tests and research related factors. Methods An observational, cross-sectional study conducted with elderly people aged 60 to 79 years. The participants underwent cognitive screening tests, interviews containing socio-demographic data and general health, as well as audiologic evaluation and temporal auditory processing (PPS and DPS) evaluation tests. A descriptive analysis of the association between the performance in temporal processing and the variables gender, age, level of education and audiometric alterations was conducted through multiple linear regression. Results 86 elderly people participated in the study, most of them female, with ages between 60 and 69. Male participants performed better in both tests as well as the participants with higher education, whereas no difference in performance was observed across the different age ranges. In the DPS, the participants with auditory alteration performed worse in relation to the ones with average frequencies of 0.5 to 4 kHz. Conclusion The male gender and higher level of education were associated with better results in the temporal ordering tests, whereas auditory alteration was associated with worse performance only in the pitch pattern sequence test.


Assuntos
Humanos , Masculino , Feminino , Idoso , Percepção do Tempo , Testes Auditivos , Audiometria , Percepção Auditiva , Estudos Transversais , Pessoa de Meia-Idade
15.
Rev. Ciênc. Méd. Biol. (Impr.) ; 19(4): 606-619, dez 30, 2020. tab, fig
Artigo em Português | LILACS | ID: biblio-1355228

RESUMO

Introdução: devido à grande prevalência do transtorno do espectro autista (TEA) e da esquizofrenia e o caráter incapacitante dessas patologias, fez-se necessário o desenvolvimento de tratamentos cada vez mais eficientes e com menos efeitos adversos. Sendo a microbiota um regulador da inflamação e tendo esta um papel fundamental na gênese dos transtornos psiquiátricos, o uso de probióticos pode ser uma alternativa segura e com baixo custo para o tratamento complementar das doenças psiquiátricas. Objetivo: realizar uma revisão narrativa sobre a eficácia do uso de probióticos na redução de sintomas clínicos e gastrointestinais, assim como da segurança no tratamento do TEA e da esquizofrenia. Metodologia: revisão dos estudos em humanos que avaliaram os efeitos terapêuticos dos probióticos no TEA e esquizofrenia. Resultados: foram selecionados 13 estudos, sendo 8 sobre TEA e 5 sobre esquizofrenia, com total de 485 pacientes. As evidências apontam melhora dos sintomas gastrintestinais dos pacientes com TEA e esquizofrenia; entretanto, sem mudanças conclusivas dos sintomas psiquiátricos na esquizofrenia, associado a potencial benefício no TEA. Conclusão: essa revisão sugere que o uso de probióticos tem um potencial benefício nos sintomas comportamentais no TEA, associado à melhora dos sintomas gastrointestinais na esquizofrenia e TEA; entretanto, não se observou mudanças nos sintomas psiquiátricos da esquizofrenia.


Introduction: due to the high prevalence of autism spectrum disorder (ASD) and schizophrenia and the disabling nature of these pathologies, it has become necessary to develop increasingly efficient treatments with less adverse effects. As the microbiota is a regulator of inflammation and having a fundamental role in the genesis of psychiatric disorders, the use of probiotics may be a safe and low-cost alternative for the complementary treatment of psychiatric diseases. Objective: to perform a narrative review on the fficacy of probiotics use in reducing clinical and gastrointestinal symptoms, and adverse effects of the use of probiotics in the treatment of ASD and schizophrenia. Methodology: review of studies in humans that evaluated the therapeutic effects of probiotics on ASD and schizophrenia. Results: 13 studies were selected, 8 on TEA and 5 on schizophrenia, with a total of 485 patients. Evidence points to improvement in gastrointestinal symptoms in patients with ASD and schizophrenia; however, there were no conclusive changes in psychiatric symptoms in schizophrenia, associated with a potential benefit in ASD. Conclusion: This review suggests that the use of probiotics has a potential benefit in behavioral symptoms in ASD, associated with the improvement of gastrointestinal symptoms in schizophrenia and ASD; however, there were no changes in the psychiatric symptoms of schizophrenia.


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Adulto , Esquizofrenia , Probióticos , Transtorno do Espectro Autista , Transtornos Mentais , Revisão , Base de Dados , Microbiota
16.
Rev. Ciênc. Méd. Biol. (Impr.) ; 19(3): 514-517, dez 5, 2020.
Artigo em Português | LILACS | ID: biblio-1358034

RESUMO

Introdução: a Síndrome Antifosfolípide é caracterizada por eventos trombóticos e perdas gestacionais de repetição e é considerada a trombofilia adquirida mais comum. Quando não está associada a alguma doença do tecido conectivo é dita primária e seu tratamento é baseado em anticoagulação por longo período com warfarin. Isso requer controle rigoroso do tempo de protrombina realizada pela monitoração dos valores de INR para que se evite em um extremo o risco de sangramento e em outro o risco de trombose. Objetivo: realizar uma revisão daa literatura sobre polimorfismos genéticos da citocromo P450 na síndrome antifosfolipide. Metodologia: revisão narrativa da literatura. Resultados: embora investigações tenham identificado a influência de vários genes na resposta ao warfarin, a maioria das evidências sugere um papel mais importante para o polimorfismo de dois genes: o gene do citocromo P450(CYP)2C9 (CYP2C9) e o gene do complexo redutase epóxido vitamina K 1 (VKORC1). De fato, o warfarin é administrado como uma mistura racêmica de S ­ e R-warfarin e estes enantiômeros são extensivamente metabolizados no fígado por diferentes enzimas do citocromo P450(CYP), com a CYP2C9 servindo como a principal enzima no metabolismo da S-warfarin. Nesse sentido, a farmacogenética da terapia com warfarin é relevante para melhorar a segurança e a efetividade dessa terapia. Polimorfismos estruturais no gene CYP2C9 criam variantes alélicos que codificam enzimas com diferentes atividades catalíticas. As freqüências alélicas destes variantes diferem entre diferentes grupos étnicos, sem estudos no Brasil em pacientes com SAF. Conclusão: o conhecimento da presença de polimorfismos genéticos da citocromo P450 em usuários de warfarin é de fundamental importância. Desde que sangramentos ou alvos subterapeuticos podem advir da presença dessas alterações genéticas.


Introduction: antiphospholipid Syndrome is characterized by thrombotic events and repeated pregnancy losses and is considered the most common acquired thrombophilia. When it is not associated with any connective tissue disease, it is said to be primary and its treatment is based on long-term anticoagulation with warfarin. This requires strict control of the prothrombin time performed by monitoring the INR values to avoid the risk of bleeding at one extreme and the risk of thrombosis at the other. Objective: To perform a review of the literature on genetic polymorphisms of cytochrome P450 in antiphospholipid syndrome. Methods: narrative literature review Results: although investigations have identified the influence of several genes on the response to warfarin, most evidence suggests a more important role for the polymorphism of two genes: the cytochrome P450 (CYP) 2C9 (CYP2C9) gene and the reductase complex gene vitamin K 1 epoxide (VKORC1). In fact, warfarin is administered as a racemic mixture of S ­ and R-warfarin and these enantiomers are extensively metabolized in the liver by different enzymes of cytochrome P450 (CYP), with CYP2C9 serving as the main enzyme in the metabolism of S-warfarin . In this sense, the pharmacogenetics of warfarin therapy is relevant to improve the safety and effectiveness of this therapy. Structural polymorphisms in the CYP2C9 gene create allelic variants that encode enzymes with different catalytic activities. The allele frequencies of these variants differ between different ethnic groups, with no studies in Brazil in patients with APS. Conclusion: knowledge of the presence of genetic polymorphisms of cytochrome P450 in users of warfarin is of fundamental importance. Since bleeding or subtherapeutic targets may result from the presence of these genetic changes.


Assuntos
Humanos , Idoso , Polimorfismo Genético , Doenças Autoimunes , Varfarina , Síndrome Antifosfolipídica , Anticoagulantes , Revisão
17.
Rev. Ciênc. Méd. Biol. (Impr.) ; 19(2): 335-341, set 24, 2020. fig, tab
Artigo em Português | LILACS | ID: biblio-1358399

RESUMO

Introdução: a dor no ombro leva a limitações e incapacidades entre adultos e idosos, merecendo atenção do fisioterapeuta. Objetivo: Avaliar o efeito imediato da técnica de Mulligan em pacientes com dor no ombro. Metodologia: trata-se de resultados preliminares de um ensaio clínico realizado entre julho de 2018 a julho de 2019. Pacientes com dor no ombro (n=44), de ambos os sexos, foram randomizados e submetidos a dois protocolos de tratamento: exercícios terapêuticos (n=22) e MWM de Mulligan (n=22), atendidos na Clínica Escola de Fisioterapia da UFBA. Todos os participantes responderam a um questionário clínico e sociodemográfico e realizaram avaliação da dor pela escala visual analógica (EVA) e algometria. Os pacientes foram tratados por dois fisioterapeutas experientes na área e, depois, foram reavaliados imediatamente. Resultados: mulheres predominaram, a média de idade foi de 56 anos no grupo Mulligan e 57 no grupo exercícios terapêuticos. Síndrome do manguito rotador predominou: 19 (86,4%) no grupo Mulligan e 15 (68%) no grupo exercícios. O ombro mais acometido foi o direito no Grupo Mulligan, (17 (77,3%); já no grupo exercícios, foi o esquerdo com 12 (55%). A cor negra foi a mais autorrelatada pelos pacientes, e poucos tinham o ensino superior completo. No grupo Mulligan, as ocupações mais informadas foram dona de casa, seguida de aposentados e autônomos. No grupo exercícios, não houve dona de casa, e sim mais aposentados e autônomos. Os dois grupos mostraram ser mais sedentários. Não houve diferença da dor pela EVA entre os grupos, antes e após o tratamento (p=0.79, p=0.56, respectivamente). Já a intensidade da dor mensurada pela algometria, tanto antes do tratamento (p=0.008) quanto depois do tratamento (p=0.04), foi diferente entre os grupos, com predomínio de melhora no grupo Exercícios. Conclusão: a MWM não foi mais eficaz que os exercícios terapêuticos na redução da dor do ombro, sendo que o exercício apresentou mais eficácia quando medido através da EVA e sem melhora significativa ao ser mensurada pela algometria após aplicação de uma única sessão de tratamento.


Introduction: shoulder pain leads to limitations and disabilities among adults and the elderly deserving attention from the physiotherapist. Objective: to evaluate the immediate effect of the Mulligan technique in patients with shoulder pain. Methodology: these are preliminary results of a clinical trial conducted from July 2018 to July 2019. Patients (n=44) with shoulder pain of both sexes were randomized and submitted to two treatment protocols: therapeutic exercises (n = 22) and Mulligan's MWM (n = 22) attended at the UFBA School of Physiotherapy Clinic. All participants answered a clinical and sociodemographic questionnaire and underwent pain assessment by visual analog scale (VAS) and algometry. The patients were treated by two experienced physiotherapists and then reassessed immediately. Results: women predominated, the average age was 56 years in the Mulligan group and 57 in the therapeutic exercises group. Rotator cuff syndrome predominated, 19 (86.4%) in the Mulligan group and 15 (68%) in the exercise group. The most affected shoulder was the right shoulder in the Mulligan Group (17 (77.3%), while in the exercise group was the left shoulder with 12 (55%).The black color was the most self-reported by the patients and few patients had higher education. In the Mulligan group the most informed occupations were housewife followed by retirees and self-employed. In the exercise group we had no housewife but more retired and self-employed. The two groups were more sedentary. There was no difference in VAS pain between the groups before and after treatment (p = 0.79, p = 0.56, respectively), while pain intensity measured by algometry both before treatment (p = 0.008) and after treatment (p = 0.04) was different between Conclusion: Mulligan's MWM was not more effective than exercise in reducing shoulder pain, and exercise was more effective when measured by VAS and without significant improvement when measured by algometry after applying a single treatment session.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Cinesiologia Aplicada , Síndrome de Colisão do Ombro , Dor de Ombro , Terapia por Exercício , Ensaio Clínico
18.
Rev. Ciênc. Méd. Biol. (Impr.) ; 19(1): 109-117, jun 17, 2020. fig, tab
Artigo em Português | LILACS | ID: biblio-1358901

RESUMO

Não há consenso na literatura quanto à associação entre postura craniocervical (PCC), disfunção temporomandibular (DTM) e oclusão dentária. Ainda assim, admite-se que a articulação temporomandibular está intimamente envolvida com a biomecânica cervical e cintura escapular. Objetivo: traçar o perfil das associações entre PCC, DTM e oclusão dentária. Metodologia: estudo observacional em corte transversal realizado em universitários, de ambos os sexos, com idade entre 18 e 40 anos. Os voluntários foram avaliados pelo RDC/TMD, biofotogrametria, sendo esta realizada através do Software de Avaliação Postural (SAPO) pelos ângulos A1(tragushorizontal), A2 (tragus-C7-horizontal), A3 (tragus ­ acrômio-vertical) e distância tóraco-cervical, além da análise quanto ao tipo de oclusão dentária. O tratamento dos dados foi feito a partir de tendência central, razão de prevalência e análise de correspondência múltipla assimétrica. Resultados: foram avaliados 88 voluntários com mediana da idade de 22 anos, sendo 27 do sexo masculino e 62 do feminino. A amostra foi dividida em quatro grupos, de acordo com a presença de DTM, padrão de dor à palpação, cefaléia, PCC e oclusão. As maiores associações observadas foram: DTM tipo II com a distoclusão tipo dois, DTM tipo I com flexão de cabeça e retificação da coluna cervical; mesioclusão com alinhamento da coluna cervical e indivíduos sem dor com anteriorização da cabeça e distoclusão tipo um. Conclusão: este estudo demonstrou que a DTM não interfere na postura da cabeça, mas que a má oclusão pode alterar a postura craniocervical nos planos sagital e frontal além de aumentar a lordose cervical.


There is no consensus in the literature about the association between craniocervical posture (CCP), temporomandibular dysfunction (TMD) and dental occlusion, although it is admitted that the temporomandibular joint is closely involved with the cervical and shoulder girdle biomechanics. Objective: to identify the profile about associations between CCP, TMJ and dental occlusion. Methodology: observational cross-sectional study, conducted on both sexes college student aged 18 to 40 years. The subjects were evaluated by RDC/TMD, biophotogrammetry, using Postural Assessment Software (SAPO), according to A1 (tragus-horizontal), A2 (tragus-C7- horizontal), A3 (tragus-acromion-vertical) and cervical thoracic distance, besides the analysis of the type of dental occlusion. Data analysis was performed by measures of central tendency, prevalence ratio and asymmetric multiple correspondence. Results: a total of 88 volunteers with a median age of 22 years were evaluated, 27 male and 62 female. The profiles was divided into four groups according to the presence of TMD, pain on palpation, headache, CCP and occlusion. The associations observed were: type II TMD with type two distocclusion, type I TMD with head flexion and cervical spine rectification; mesiocclusion with cervical spine alignment and pain-free individuals with anteriorization of the head and distocclusion type one. Conclusão: this study demonstrated that TMD does not interfere with the head position, but that malocclusion may alter craniocervical posture in the sagittal and frontal planes and increase cervical lordosis.


Assuntos
Humanos , Masculino , Feminino , Adulto , Palpação , Postura , Articulação Temporomandibular , Síndrome da Disfunção da Articulação Temporomandibular , Cefaleia , Má Oclusão , Estudos Transversais , Estudo Observacional
19.
J. oral res. (Impresa) ; 9(2): 142-149, abr. 30, 2020. ilus, tab
Artigo em Inglês | LILACS | ID: biblio-1151910

RESUMO

Objective: This study investigated the effect of endogenous erosion on the microhardness of dentine and a nanofilled composite resin. Procedures for preventing erosion were also studied. Materials and Methods: 90 bovine dentine specimens were divided into three groups in accordance with the method for preventing: negative control, topical application of fluoride and resin-modified glass ionomer varnish. 120 composite resin specimens were distributed into four groups, which also included a resin sealant, among the preventive procedures. Specimens were then randomly divided into three sub-groups according to the exposure to simulate gastric acid solution and subsequent remineralization: negative control, 9 and 18 cycles. Surface analysis was carried out by measuring the Knoop hardness. The data obtained were statistically analyzed using 2-way ANOVA and Tukey test. Result: The mean hardness of dentine and of the composite specimens resin exhibited lower hardness after 18 cycles. However, the resin-modified glass ionomer varnish resulted in greater values compared to the other preventive procedures. Conclusion: A resin-modified glass ionomer varnish seems to be a promising method for minimizing the damage caused by endogenous acid, but its protection can be reduced depending on the intensity of the erosive challenge.


Objetivo: Este estudio investigó el efecto de la erosión endógena sobre la microdureza de la dentina y una resina compuesta de nanorrelleno. También se estudiaron los procedimientos para prevenir la erosión. Materiales and Métodos:90 muestras de dentina bovina se dividieron en tres grupos de acuerdo con el método para prevenir: control negativo, aplicación tópica de fluoruro y barniz de ionómero de vidrio modificado con resina. Se distribuyeron 120 muestras de resina compuesta en cuatro grupos, que también incluían un sellador de resina, entre los procedimientos preventivos. Las muestras se dividieron al azar en tres subgrupos de acuerdo con la exposición para simular la solución de ácido gástrico y la remineralización posterior: control negativo, 9 y 18 ciclos. El análisis de la superficie se realizó midiendo la dureza Knoop. Los datos obtenidos se analizaron estadísticamente mediante ANOVA de 2 vías y prueba de Tukey. Resultados: La dureza media de la dentina y de la resina de muestras compuestas exhibió una dureza más baja después de 18 ciclos. Sin embargo, el barniz de ionómero de vidrio modificado con resina resultó en valores mayores en comparación con los otros procedimientos preventivos. Conclusión: Un barniz de ionómero de vidrio modificado con resina parece ser un método prometedor para minimizar el daño causado por el ácido endógeno, pero su protección puede reducirse dependiendo de la intensidad del desafío erosivo.


Assuntos
Animais , Bovinos , Erosão Dentária/prevenção & controle , Resinas Compostas , Dentina , Adesivos Dentinários , Dureza , Ácido Clorídrico
20.
Rev. CEFAC ; 22(2): e17418, 2020. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1136467

RESUMO

ABSTRACT Purpose: to investigate the possible association between the severity of the temporomandibular disorder, cervical pain, and mandibular function impairment. Methods: is a cross-sectional, descriptive study, conducted with 32 individuals with temporomandibular disorder, categorized by degree of severity, according to the Fonseca Index. Using the diagnosis criteria for temporomandibular disorder, the likely etiological factors for the disorder were established, as well as the intensity of the functional disability, resulting from cervical pain and of the mandibular impairment. The data obtained were statistically treated, adopting the significance level of 5%. Results: the mean age was 33.8 years, 90.6% being females. As for the degree of disorder, 56.3% presented severe TMD, followed by 28.1% showing a moderate one. The myogenic etiology was present in 93.7% of the patients. Cervical pain was present in 90.6% of them, of which, 59.4% presented a mild disability, and 25%, a moderate one. Considering the mandibular function, 46.9% of the patients presented a low, 40.6%, a moderate, and 12.5%, a severe impairment. There was a statistically significant association between cervical pain and mandibular function (p = 0.011). However, although there was an increase in cervical disability and in mandibular impairment as the severity of the TMD also increased, these associations were not statistically significant (p = 0.178 and p = 0.102, respectively). Conclusion: it can be stated that there is a higher prevalence of severe TMD and of myogenic origin, and that cervical pain influences, directly, the mandibular function, which is not necessarily related to the severity of the temporomandibular alteration. Likewise, such severity does not present a relationship to mandibular function impairment either.


RESUMO Objetivo: investigar possível associação entre severidade da disfunção temporomandibular, cervicalgia e limitação funcional mandibular. Métodos: estudo seccional descritivo, em 32 indivíduos com disfunção temporomandibular, categorizados de acordo com o grau de severidade segundo o Índice de Fonseca. Utilizando-se o Critérios Diagnósticos de Pesquisa em Disfunção Temporomandibular, estabeleceram-se prováveis fatores etiológicos da disfunção e a intensidade de incapacidade funcional cervical e mandibular, avaliados pelo Índice de Incapacidade Relacionada à Dor no Pescoço e Questionário de Limitação Funcional Mandibular respectivamente. Os dados obtidos foram tratados estatisticamente, adotando-se nível de significância de 5%. Resultados: a média de idade foi de 33,8 anos, sendo 90,6% pertencentes ao gênero feminino. Quanto à severidade da disfunção, 56,3% possuíam o tipo severo, sendo moderada em 28,1%. Em 93,7%, verificou-se etiologia miogênica. A cervicalgia esteve presente em 90,6% dos pacientes, dos quais 59,4% apresentaram incapacidade leve e 25% moderada. Quanto à função mandibular, houve baixa limitação em 46,9%, moderada em 40,6%, tendo sido severa em 12,5%. Houve associação estatisticamente significante entre a cervicalgia e a função mandibular (p=0,011). Contudo, embora tenha havido aumento na incapacidade cervical e na limitação mandibular com o aumento da severidade da disfunção temporomandibular, estas associações não foram estatisticamente significantes (p=0,178 e p=0,102, respectivamente). Conclusão: é possível afirmar que há maior prevalência de disfunção temporomandibular de intensidade severa e de origem miogênica, e que a cervicalgia influencia diretamente a função mandibular, não estando necessariamente relacionada à severidade da disfunção temporomandibular. Da mesma forma, esta última também não apresenta relação direta com a limitação da função mandibular.

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