[The relevance of PET/CT for the surgical management of neuroendocrine neoplasms]. / Bedeutung der PET/CT für die Chirurgie neuroendokriner Neoplasien.

Neuroendocrine neoplasms (NEN) are rare malignancies with a wide spectrum of metastatic potential which originate from the endocrine cells of the body and express somatostatin receptors. The (68)gallium somatostatin receptor positron emission tomography-computed tomography (PET/CT) technique is the most sensitive method of assessment of well-differentiated NENs and for the detection of cancer of unknown primary (CUP syndrome) NENs. Imaging with 18F-fluorodeoxyglucose (18F-FDG PET/CT) is indicated in poorly differentiated neuroendocrine carcinomas. The receptor-dependent imaging of NENs has a decisive impact on further management.

Chronic osteomyelitis of the femur: value of PET imaging.

The purpose of this report is to discuss FDG-PET as a potentially new imaging tool in the diagnosis of infections of osteosynthetic material. We present a patient with a poly-trauma who developed a chronic osteomyelitis and ostitis after repeated osteosynthesis in a fibular transplant to the left femur. Work up included MRI, antigranulocyte antibody scintigraphy and positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG). Infection of the fibular transplant was demonstrated clearly by PET but not by the other methods. Positron emission tomography may become an important indication in the diagnosis and follow-up of bone infection.

[Uteroplacental circulation and functional status of the fetoplacental unit in risk pregnancies with special reference to late gestosis]. / Uteroplazentare Durchblutung und Funktionszustand der fetoplazentaren Einheit bei Risikoschwangeren unter besonderer Berücksichtigung der Spätgestose.

Trial to define position and variability of radioisotope functional diagnostics of placental perfusion in comparison with urinary estrogen excretion by serial examinations. - In case of placental insufficiency estrogen values are significantly reduced starting from the 32nd to 35th gestational week as compared with normal values. In general, placenta perfusion shows delayed half-life periods of the increase in activity in all risk pregnancies beginning from the 28th week of pregnancy. A direct correlation between estrogen values and placenta perfusion can only be detected in cases of chronic placental insufficiency with intrauterine growth retardation. A prolonged perfusion time reveals a fetal hypotrophy in 53% of the cases. Late gestosis takes the first place about all risk pregnancies, connected with placental insufficiency in 30% of the cases. The tendency towards a development of placental insufficiency can be early detected by determination of placental perfusion time.

Long term toxicological studies on the progestin STS 557.

The toxicity of 17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9-dien-3-one (STS 557) was studied by its oral administration of 0.1, 1.0 or 10.0 mg/kg/day to Wistar rats for six months, and of 0.01, 0.1 or 1.0 mg/kg/day to beagle dogs for six months, respectively. Levonorgestrel at a dose of 1.0 mg/kg/day was used as the standard in the dog study. With respect to the progestational activity of the compound the main target organs were the hypophysis, the reproductive organs and the adrenals. Mammary hyperplasia was observed in dogs treated with STS 557 or levonorgestrel at the dose of 1.0 mg/kg/day, but in no case mammary nodules could be detected. At the dose of 1.0 mg/kg/day STS 557 and levonorgestrel were found to increase the plasma insulin response to i.v. glucose in bitches, but neither the mean blood glucose levels nor the glucose utilization were affected. Moreover, during administration of both steroids to dogs temporary changes in serum concentrations of triglycerides and total cholesterol were noted. The results obtained in rats and dogs from functional and morphological investigations did not reveal any toxic side effects of STS 557 on the liver, the kidneys, the bone marrow or on blood coagulation. The effects on the reproductive organs observed following STS 557 especially in dogs are related to both the hormonal effects of the compound and the specific response of the dog to potent progestagens.

[Significance of the measurement of placental perfusion by radionuclides in prenatal diagnosis in pregnancies at risk]. / Die Bedeutung der nuklearmedizinischen Plazentaperfusionsmessung im Rahmen der pränatalen Diagnostik bei Risikoschwangeren.

The evaluation of placental perfusion measurements in 102 high-risk pregnancies from the 28th to 41st gestational week is described. --Following an injection of In113m-chloride, the half-life value of the rise in activity was determined by computer evaluation according to a single-compartment model. --Mean value of the half-life value of the rise of the placental perfusion curve is 12.55 +/- 2.42 seconds (33 normal test persons). --A half-life value of 20.62 +/- 2.43 seconds was determined in high-risk pregnancies. --In cases of EPH-gestosis a half-life value of 22.55 +/- 3.64 seconds was determined. Individual cases showed values of 50 seconds for gestosis. There was no correlation between the half-life value and the size of the placenta and or gestational age.

[Effects of Turisynchron and Suisynchron on the thyroid gland in rats during simultaneous administration of TSH]. / Uber den Einfluss von TURISYNCHRON und SUISYNCHRON auf die Rattenschilddrüse bei gleichzeitiger Applikation von TSH

Thyrotrophin was injected i/p at 2 I.U. daily simultaneously with oral administration of Turisynchron at 100 mg/kg or Suisynchron at 125 mg/kg daily for five days to Wistar rats. The uptake of radio-iodine by the thyroid was reduced, and there were slight changes in thyroid structure. Suisynchron produced a milder inhibition of thyroid regulatory mechanisms than Turisynchron.

The budgerigar (Melopsittacus undulatus) as endocrinological test model. Thyroxine transport in blood.

By comparing in-vivo and in-vitro investigations the transport protein of thyroxine in the budgerigar (Melopsittacus undulatus) was determined. Electrophoretic and auto-radiographic methods were applied. Both investigations show the alpha-globulin to be a thyroxine-binding protein. The contradictions to other investigators are discussed. The experimental animal as an endocrinological model of the thyroid for questions of human medicine is recommended.

[The budgerigar (Melopsittacus undulatus)--a suitable endocrinological model of the thyroid gland]. / Der Wellensittich (Melopsittacus undulatus) --ein geeignetes endokrinologisches Modell der Schilddrüse

The budgerigar (Melopsittacus undulatus) was tested as an endocrinological model of the thyroid gland. For this purpose, 514 animals were applied in our investigation. Besides the elaboration of an animal-specific method for the registration of thyroid function, questions of iodine metabolism, especially the influence of several endogenous and exogenous factors, were elucidated. Taking into consideration the results received we examined the model with regard to its application in functional, morphological, pharmaceutical, and radiotherapeutical questions. The results show that, by means of the method used, the model answers the various questions unreservedly. Further advantage recommend the budgerigar as a model of the thyroid gland.