Mass-manufacturable scintillation-based optical fiber dosimeters for brachytherapy.

Scintillation-based fiber dosimeters are a powerful tool for minimally invasive localized real-time monitoring of the dose rate during Low Dose Rate (LDR) and High Dose Rate (HDR) brachytherapy (BT). This paper presents the design, fabrication, and characterization of such dosimeters, consisting of scintillating sensor tips attached to polymer optical fiber (POF). The sensor tips consist of inorganic scintillators, i.e. Gd2O2S:Tb for LDR-BT, and Y2O3:Eu+4YVO4:Eu for HDR-BT, dispersed in a polymer host. The shape and size of the tips are optimized using non-sequential ray tracing simulations towards maximizing the collection and coupling of the scintillation signal into the POF. They are then manufactured by means of a custom moulding process implemented on a commercial hot embossing machine, paving the way towards series production. Dosimetry experiments in water phantoms show that both the HDR-BT and LDR-BT sensors feature good consistency in the magnitude of the average photon count rate and that the photon count rate signal is not significantly affected by variations in sensor tip composition and geometry. Whilst individual calibration remains necessary, the proposed dosimeters show great potential for in-vivo dosimetry for brachytherapy.

Miniature freeform flow-line lightguide for sensing: from design to fabrication.

We present the development of a compact (about 1.3 × 2.0 × 20 mm3) freeform optical lightguide for sensing applications, from the conceptual design to the fabrication through injection molding. The design of the optic is based on the flow-line method from Nonimaging Optics, which allows the desired optical functionalities (45° half-acceptance and 40° beam steering) while meeting particularly tight mechanical and geometrical constraints. An extensive analysis of the effects of fabrication parameters on the performances demonstrates the importance of minimizing the fillet radius. This requisite inspired a special procedure for designing the mold, which is built as a "3D puzzle" assembly of separate pieces, each one dedicated to one specific side surface of the lightguide. This technique enables uniform optical quality on all the optic's surfaces and removes the need of a fillet radius in the mold. At present, the first lightguide prototypes have been fabricated; after the coating phase, they will be ready for the validation stage.