Treatment of bacterial infections in children with sultamicillin.

Infections caused by beta-lactamase-producing pathogens should be treated with beta-lactamase-stable antibiotics or with penicillin-derivatives in combination with inhibitors. Sulbactam, which acts as a beta-lactamase inhibitor, works in conjunction with ampicillin by extending the spectrum of ampicillin to include ampicillin-resistant germs. Sultamicillin is an active substance that combines sulbactam and ampicillin to form an ester. Sultamicillin's bio-availability remains high even after eating. For children, the dosage is 50 mg/kg/day, in two doses. The prospective study of 100 patients of between 6 months and 12 years of age with respiratory, skin, and mucous membrane infections produced a therapy success rate of 90%. The most significant side-effects were exanthemas and diarrhoea.

[Purulent meningitis in childhood caused by Haemophilus influenzae with ampicillin and chloramphenicol resistance]. / Meningitis purulenta im Kindesalter durch Haemophilus influenzae mit Ampicillin- und Chloramphenicolresistenz.

A report is given on two children suffering from meningitis caused by ampicillin- and chloramphenicol-resistent Haemophilus influenzae. Since effective therapy has been started with delay, recovery was affected with complications. The need for the early determination of minimal inhibitory concentrations and detection of beta-lactamase-production is emphasized as well as for repeated measurement of C-reactive protein in serum. Cefotaxime is recommended in case of presence of resistent Haemophilusstrains.

[Rotavirus diarrhea in childhood]. / Rotavirus-Diarrhoe im Kindesalter.

Electron microscopy of 350 diarrhoeal faeces revealed Rotavirus-particles in 145 cases. All patients with Rotavirus-infections showed symptoms of acute gastroenteritis lasting 1 to 8 days. Additionally to diarrhoea most cases presented fever and vomiting. None of the patients showed toxicosis.

[Preparation and testing of polyvalent EDTA-Na-extract vaccine from Escherichia coli strains pathogenic to Swine]. / Herstellung und Prüfung eines polyvalenten EDTA-Na-Extraktimpfstoffes aus schweinepathogenen Escherichia-coli-Stämmen.

Monovalent vaccines were prepared of E. coli strains with pathogenicity to swine by means of a technique described elsewhere. A polyvalent vaccine was obtained by mixing the monovalent vaccines. This polyvalent vaccine was tested by criteria usually applied to vaccine of E. coli strains with pathogenicity to man, and it exhibited the same quality characteristics.

[Laboratory experiments with a polyvalent extract vaccine for oral immunization against E. coli enteritis]. / Laboratoriumsversuche mit einem polyvalenten Extraktimpfstoff zur Oralimmunisierung gegen Enteritiscoli-Infektionen.

Bacteria of E. coli causing enteritis can be extracted by EDTA-sodium. These extracts having lower dry weights result in better protective effects in contrast to sodium-deoxycholate extracts. The EDTA-sodium extracts can be concentrated, purified and sterile filtrated. Thus the production of polyvalent vaccines is possible. A direct relation exists between the effectiveness of the extracts and the virulence of the strains used for extraction. The more virulent the original strain the better is the protective effect of the vaccine produced by extraction of the original strain. The single components of the polyvalent vaccine show a certain improvement of their protective effects. For estimating the immunizing dose, it is necessary to consider the limiting dose. When exceeding this dose the protective effect or the vaccine does not further increase but remains constant of even decreases. The immunizing dose wanted must be greater than the ED50 but smaller than the limiting dose. Extremely high oral doses of vaccine result in symptoms of incompatibility in mice.