[Chronic hepatitis C. Epidemiology and therapeutic results in 255 cases]. / Hepatitis crónica por virus C. Datos epidemiológicos y de eficacia terapéutica en 255 casos.

A review of the statistics of the years 2003, 2004 to August 2005 has provided data corresponding to 255 patients that were diagnosed and included in the treatment protocol of chronic hepatitis C. Epidemiologically, the 2/1 man/woman ratio, mean age of 43 years and history of transfusion (transf.) in 18.6% are to be noted. Parenteral drug addicition (PDA) in 17% and alcoholism in 14.1%, of unknown origin in 58.74% of the cases. 79.05% corresponded to genotype 1, 4.74% to genotype 4, 14.22% to genotype 3, and 2.76% to genotype 2. Genotypes 1 and 4 were included in the treatment regime with PEG-Interferon alpha-2b + Ribavirin (with doses adjusted for weight) and those of genotype 3 and 2 in the regime with Interferon alpha 2b + Ribavirin. In 95 cases of Genotype 1 (87) and 4 (8), a sustained viral response (SVR) of 61.95% was obtained, with three drop-outs. In the 20 cases of genotypes 3 (17) and 2 (3), SVR was 85%, with no drop-outs. In the 20 cases of genotypes 3 (17) and 2 (3), SVR was 85%, with no drop-outs. The adjustment of treatment to body mass involved an economic savings per case amounting to 868.94 Euro. Finally, in 16 cases of Genotype 1, before treated with Interferon in monotherapy, a sustained viral response of 31.25% was obtained with combined therapy.

Hepatitis crónica por virus C. Datos epidemiológicos y de eficacia terapéutica en 255 casos / Chronic hepatitis C. Epidemiology and therapeutic results in 255 cases

Revisando la estadística de los años 2003, 2004, hasta agosto de 2005, tenemos datos correspondientes a 255 pacientes que fueron diagnosticados e introducidos en protocolo de tratamiento de hepatitis crónica por virus C. Epidemiológicamente es de destacar la proporción de 2/1 entre hombre/mujer, edad media de 43 años y antecedentes de transfusión (Transf.) en un 18,6%. Adicción a drogas por vía parenteral (ADVP) en el 17% y etilismo del 14,1%, siendo el origen desconocido en el 58,74% de los casos. Correspondieron al genotipo 1 el 79,05% de los casos, genotipo 4 el 4,74%, genotipo 3 el 14,22% y genotipo 2 el 2,76%. Los genotipos 1 y 4 fueron introducidos en protocolo de tratamiento con PEG-interferón alfa-2b + ribavirina (con dosis ajustadas según peso) y los de genotipo 3 y 2 con interferon alfa 2b + ribavirina. En los 95 casos de genotipo 1 (87) y 4 (8), se obtuvo una respuesta viral sostenida (RVS) del 61,95%, con tres abandonos. De los 20 casos de genotipos 3 (17) y 2 (3), la RVS fue del 85%, sin ningún abandono El ajuste del tratamiento al peso supuso un ahorro económico por caso, teniendo sólo en cuenta PEG-interferón, que se cifró en 868,94 e. Por último, grupo de 16 casos del genotipo 1 había sido tratado anteriormente con interferón en monoterapia, consiguiéndose con el nuevo tratamiento una RVS en 5 casos de los primeros (31,25%)

A review of the statistics of the years 2003, 2004 to August 2005 has provided data corresponding to 255 patients that were diagnosed and included in the treatment protocol of chronic hepatitis C. Epidemiologically, the 2/1 man/woman ratio, mean age of 43 years and history of transfusion (transf.) in 18.6% are to be noted. Parenteral drug addcition (PDA) in 17% and alcoholism in 14.1%, of unknown origin in 58.74% of the cases. 79.05% corresponded to genotype 1, 4.74% to genotype 4, 14.22% to genotype 3, and 2.76% to genotype 2. Genotypes 1 and 4 were included in the treatment regime with PEG-Interferon alpha-2b + Ribavirin (with doses adjusted for weight) and those of genotype 3 and 2 in the regime with Interferon alpha 2b + Ribavirin. In 95 cases of Genotype 1 (87) and 4 (8), a sustained viral response (SVR) of 61.95% was obtained, with three drop-outs. In the 20 cases of genotypes 3 (17) and 2 (3), SVR was 85%, with no drop-outs. In the 20 cases of genotypes 3 (17) and 2 (3), SVR was 85%, with no drop-outs. The adjustment of treatment to body mass involved an economic savings per case amounting to 868.94 e. Finally, in 16 cases of Genotype 1, before treated with Interferon in monotherapy, a sustained viral response of 31.25% was obtained with combined therapy