Preparation and persistence of deploying attention to locations or stimulus structures: Evidence from intermixed probe trials.

Attention can be directed to the global or local level of a visual stimulus (i.e., Navon figure). Previous studies yielded reliable trial-to-trial level switch costs (i.e., worse performance when responding to the other level than on a previous trial), even though level cueing effects indicated anticipatory deployment of attention to the upcoming target level. To investigate the interplay of attentional preparation and persistence, we applied a probe trial method assumed to ensure a high degree of preparation for the upcoming target level and minimizing stimulus-specific proactive interference. Mirroring previous findings obtained in the domain of spatial attention, we found evidence for anticipatory attentional focusing on global/local target levels but not for persistence of the attentional set adopted on the previous trial. In a second experiment, we prevented preparation for upcoming attentional demands (in both global-local and spatial attention tasks). This resulted in the modulation of performance (in critical probe trials) by the attentional demands of the predecessor trial. Together, our findings demonstrate sensitivity of the probe trial method for attentional persistence and raise the possibility that such persistence can be completely eliminated by sufficiently strong preparation for the attentional demands of the following trial.

Electrophysiological correlates of proportion congruency manipulation in a temporal flanker task.

Response conflict evoked by a distractor stimulus object in interference tasks is associated with longer reaction times and a pronounced ERP component referred to as the fronto-central N2. Increasing the proportion congruency (PC, i.e., the proportion of trials in which target and distractor are associated with the same response) is assumed to enhance distractor-evoked conflict via defocusing of attention. Findings concerning the effect of the PC on the N2 in Eriksen flanker task experiments have been inconsistent, however, lending little support to the notion that the N2 reflects a conflict monitoring process. Here, we analyze the N2 in a temporal flanker task, in which the distractor stimuli, presented in advance of the target, elicit pronounced activation of the associated responses (as inferred from the lateralized readiness potential) when the PC is high. Consistent with result pattern obtained in other tasks involving successive presentation of the distractor and the target, conflict trials in a high-PC condition evoked a particularly large N2. These findings accord with the assumption that the N2 reflects either conflict monitoring or conflict-induced regulatory measures (i.e., reactive control). In light of the discrepancy of results obtained under conditions of simultaneous and successive distractor-target presentation, we speculate that the N2 is pronounced in situations that offer strong hints for classifying dominating response activation as incorrect, possibly reflecting particular control to counter this activation. Additional properties of the temporal flanker task, related to ERP investigations, are discussed.

Adjustments of selective attention to response conflict - controlling for perceptual conflict, target-distractor identity, and congruency level sequence pertaining to the congruency sequence effect.

The congruency sequence effect (CSE) describes the performance difference of congruent trials (in which target and distractor stimuli are associated with the same response) compared to incongruent trials (in which target and distractor stimuli are associated with different responses) as a function of the preceding congruency level (congruent trials relative to incongruent trials). The CSE is commonly interpreted as a measure of conflict-induced attentional adjustment. Although previous research has made substantial progress aiming at controlling for alternative explanations of the CSE, both task-specific and fundamental confounds have remained. In the current study, we used a temporal flanker task, in which two stimuli (i.e., distractor and target) are presented in rapid succession, and extended previous demonstrations of a CSE in flanker tasks by deconfounding target-distractor congruency from perceptual similarity. Using a four-choice task, we could also control for the reversal of distractor-response priming after incongruent trials (which is only feasible in two-choice tasks). Furthermore, we controlled for all confounds based on the sequence (i.e., repetition versus alternation) of the congruency level - such as feature sequence effects, distractor-response contingency switch costs, or temporal learning - by probing the allocation of attention to the points in time of presentation of the first and the second stimulus of a trial. This was achieved by intermixing trials of a temporal search task. The performance accuracy results in this task were consistent with a stronger attentional bias in favor of the target stimulus' temporal position after incongruent than after congruent trials.

No evidence for the reduction of task competition and attentional adjustment during task-switching practice.

Performance in task switching experiments is worse when the current stimulus is associated with different responses in the two tasks (i.e., incongruent condition) than when it is associated with the same response (i.e., congruent condition). This congruency effect reflects some sort of application of the irrelevant task's stimulus-response translation rules. Manipulating the recency and the proportion of congruent and incongruent trials results in a modulation of the congruency effect (i.e., Congruency Sequence Effect, CSE, and Proportion Congruency Effect, PCE, respectively), suggesting attentional adjustment of processing weights. Here, we investigated the impact of task switching practice on the congruency effect and the modulation thereof by (a) re-analyzing the data of a task switching experiment involving six consecutive sessions and (b) conducting a novel four-session experiment in which the proportions of congruent and incongruent trials were manipulated. Although practice appeared to reduce the reaction times overall and the task switch costs (i.e., slower reaction times after task switches than after task repetitions) to an asymptotic level, the congruency effect as well as its modulations remained remarkably constant. These findings thus do not provide evidence that conflict effects between tasks and attentional adjustment are affected by task switching practice.

Target-distractor congruency: sequential effects in a temporal flanker task.

The Congruency Sequence Effect (CSE) denotes the common finding that distractor-target Congruency Effects are reduced after incongruent compared to after congruent trials. Although the CSE is widely attributed to attentional adjustment (i.e., increasing or decreasing the bias in attentional weights regarding processing the target or distractor), unequivocal evidence for this assumption is missing. To investigate the CSE and attentional adjustment we used a temporal flanker task and intermixed a "temporal search task", in which a target stimulus occurred randomly at one of two temporal positions, corresponding to the temporal positions of the target and the distractor occurrence in the temporal flanker task. We observed a CSE that could not be explained in terms of feature sequences, distractor-related contingencies, or a strategy of reversed distractor-response priming after incongruent trials. Furthermore, following a temporal search task trial, the Congruency Effect was larger when the search target occurred on the first than on the second temporal position, demonstrating that a reduced attentional bias towards the second temporal position increased interference from a distractor presented on the first temporal position. This supports a crucial assumption of the attentional adjustment account of the CSE. Performance in the temporal search task, however, provided no evidence for attentional adjustment.

The time course of distractor-based response activation with predictable and unpredictable target onset.

Electrophysiological recording in a temporal flanker task (i.e., distractors preceding the targets) has demonstrated that distractor processing is adjusted to the overall utility of the distractors. Under high utility, that is, distractors are predictive of the target/response, distractors immediately activate the corresponding response (as indicated by the lateralized readiness potential, LRP). This activation has been shown to be markedly postponed when the target predictably occurs delayed. To investigate the occurrence and time course of distractor-related response activation under conditions of unpredictable target onset, we randomly varied the stimulus-onset asynchrony (SOA) between distractors and targets and recorded the distractor-evoked LRP. When the distractor utility was high, an LRP occurred shortly after distractor presentation. In case of a long SOA the time course of this LRP was characterized by a drop back to baseline and a subsequent re-activation that reached a substantial level before target onset. These results suggest that distractor processing is characterized by sophisticated adjustments to experienced utility and temporal constraints of the task as well as by further control processes that regulate premature response activation.

Selective impairment of attentional set shifting in adults with ADHD.

BACKGROUND: Task switch protocols are frequently used in the assessment of cognitive control, both in clinical and non-clinical populations. These protocols frequently confound task switch and attentional set shift. The current study investigated the ability of adult ADHD patients to shift attentional set in the context of switching tasks. METHOD: We tested 38 adults with ADHD and 39 control adults with an extensive diagnostic battery and a task switch protocol without proactive interference. The experiment combined orthogonally task-switch vs. repetition, and attentional set shift vs. no shift. Each experimental stimulus had global and local features (Hierarchical/"Navon" stimuli), associated with corresponding attentional sets. RESULTS: ADHD patients were slower than controls in task switch trials with a simultaneous shift of attention between global/local attentional sets. This also correlated significantly with diagnostic scales for ADHD symptoms. The patients had more variable reaction times, but when the attentional set was kept constant neither were they significantly slower nor showed higher task switch costs. CONCLUSION: ADHD is associated with a deficit in flexible deployment of attention to varying sources of stimulus information.

Shifting the set of stimulus selection when switching between tasks.

Switching between tasks associated with different requirements of stimulus selection may suffer interference from persisting attentional settings or processes of reconfiguration, possibly constituting a source of task switch costs (i.e., impaired performance in task switch trials compared to task repetition trials). To explore the processes involved in task switching with and without a switch in stimulus selection requirements, we administered a task-switching paradigm that involved task-unique sets of hierarchical (Navon) stimuli, preventing stimulus-related proactive interference (i.e., impaired responding to a stimulus that was previously processed in the context of a different task), and varied, between groups of participants, whether the target stimulus level (i.e., global vs. local) was held constant or varied between the tasks. Mixing target levels impaired performance overall and increased the task switch costs. Moreover, (within-task) global-local congruency effects were larger when target levels were mixed, particularly in task switch trials, suggesting relatively stronger stimulus processing according to the attentional set of the other task. In a second phase of the experimental session, the target level was changed persistently for either one or for both tasks, presumably evoking stimulus-related proactive interference. This change yielded large task switch costs and global-local congruency effects when it resulted in mixed target levels, but not when it resulted in a constant target level. These results are consistent with the notion that stimulus-related proactive interference is reduced by constant withdrawal of attention from the perceptual dimension of the interference-eliciting stimuli.

Adoption of Task-Specific Sets of Visual Attention.

Evidence from behavioral and physiological studies suggests attentional weighting of stimulus information from different sources, according to task demands. We investigated the adoption of task-specific attentional sets by administering a flanker task, which required responding to a centrally presented letter while ignoring two adjacent letters, and a same-different judgment task, which required a homogenous/heterogeneous classification concerning the complete three-letter string. To assess the distribution of attentional weights across the letter locations we intermixed trials of a visual search task, in which a target stimulus occurred randomly in any of these locations. Search task reaction times displayed a stronger center-to periphery gradient, indicating focusing of visual attention on the central location, when the search task was intermixed into blocks of trials of the flanker task than into blocks of trials of the same-different task (Experiment 1) and when a cue indicated the likely occurrence of the flanker task as compared to the likely occurrence the same-different task (Experiment 2). These findings demonstrate flexible adoption of task-specific sets of visual attention that can be implemented during preparation. In addition, responses in the intermixed search task trials were faster and (marginally significantly) more error-prone after preparation for a (letter) task repetition than for a task switch, suggesting that response caution is reduced during preparation for a task repetition.

Strategic control over extent and timing of distractor-based response activation.

In choice reaction time (RT) tasks, performance is often influenced by the presence of nominally irrelevant stimuli, referred to as distractors. Recent research provided evidence that distractor processing can be adjusted to the utility of the distractors: Distractors predictive of the upcoming target/response were more attended to and also elicited stronger motor responses. In an event-related potential (ERP) study, we investigated whether not only the extent of distractor processing (as suggested by these previous results), but also the timing of distractor-based response activation is subject to strategic control. In a temporal flanker task, in which a distractor stimulus preceded the target, we manipulated distractor utility (i.e., by varying the proportion of congruent distractor-target combinations, 75% vs. 25%) as well as the stimulus onset asynchrony (SOA) between distractors and targets (350 ms vs. 1,000 ms) in different blocks of trials. The distractor-locked lateralized readiness potential (LRP) was overall larger in blocks with a high proportion of congruent trials indicating stronger distractor-based response activation when distractor utility was high. Of importance, the LRPs occurred overall later when the SOA was long. This suggests that distractor-based response activation can be postponed and thus adjusted to the temporal factors of the context. Modulations of early visual potentials (P1 and N1) indicate that this postponement of motor activation is related to both sensory-perceptual downgrading of distractor stimuli and reduced activation of task-relevant stimulus-response transformation processes at the time of distractor perception. (PsycINFO Database Record

Utilidad de los diferentes modelos clínicos en la exclusión de la trombosis venosa profunda en un área de urgencias hospitalarias / Usefulness of clinical prediction rules for ruling out deep vein thrombosis in a hospital emergency department

Objetivos: Comparar la efectividad de los modelos clínicos más conocidos en combinación con el dímero D para la exclusión de un diagnóstico de trombosis venosa profunda (TVP) en un área de urgencias hospitalarias (AUH). Método: Estudio retrospectivo de serie de casos con análisis transversal a partir de un registro que incluyó a todo paciente atendido por una sospecha clínica de TVP en miembros inferiores en un AUH entre los años 1998 y 2002. Se calcularon los 10 modelos clínicos y se determinó el dímero D a todos los pacientes. La prueba de referencia fue el diagnóstico de TVP realizado por parte de un radiólogo independiente y enmascarado a los datos clínicos mediante la realización de una ecografía. Se analizó la efectividad de la estrategia “baja probabilidad clínica y dímero D negativo” de cada modelo en relación a los resultados ecográficos obtenidos. Resultados: Del total de 861 casos del registro, se seleccionaron 577 pacientes con una edad media de 66,7 (DE 14,2) años. Se realizó el diagnóstico de TVP en 145 pacientes (25,1%). Sólo el modelo de Wells y otros 4 modelos presentaron un porcentaje de falsos negativos inferior al 2%. De ellos, el modelo de Wells seguido del publicado por Johanning seleccionaron a un mayor porcentaje de pacientes (15,6% y 11,6%, respectivamente). Conclusiones: El presente estudio muestra que existen diversos modelos clínicos que se pueden aplicar de forma segura en el ámbito de urgencias, aunque ninguno de ellos ha documentado ser más efectivo que la escala de Wells (AU)

Objective: To compare the efficacy of the most familiar clinical prediction rules in combination with D-dimer testing to rule out a diagnosis of deep vein thrombosis (DVT) in a hospital emergency department. Methods: Retrospective cross-sectional analysis of the case records of all patients attending a hospital emergency department with suspected lower-limb DVT between 1998 and 2002. Ten clinical prediction scores were calculated and D-dimer levels were available for all patients. The gold standard was ultrasound diagnosis of DVT by an independent radiologist who was blinded to clinical records. For each prediction rule, we analyzed the effectiveness of the prediction strategy defined by “low clinical probability and negative D-dimer level” against the ultrasound diagnosis. Results. A total of 861 case records were reviewed and 577 cases were selected; the mean (SD) age was 66.7 (14.2) years. DVT was diagnosed in 145 patients (25.1%). Only the Wells clinical prediction rule and 4 other models had a false negative rate under 2%. The Wells criteria and the score published by Johanning and colleagues identified higher percentages of cases (15.6% and 11.6%, respectively). Conclusions: This study shows that several clinical prediction rules can be safely used in the emergency department, although none of them have proven more effective than the Wells criteria (AU)

[Usefulness of clinical prediction rules for ruling out deep vein thrombosis in a hospital emergency department]. / Utilidad de los diferentes modelos clínicos en la exclusión de la trombosis venosa profunda en un área de urgencias hospitalaria.

OBJECTIVES: To compare the efficacy of the most familiar clinical prediction rules in combination with D-dimer testing to rule out a diagnosis of deep vein thrombosis (DVT) in a hospital emergency department. MATERIAL AND METHODS: Retrospective cross-sectional analysis of the case records of all patients attending a hospital emergency department with suspected lower-limb DVT between 1998 and 2002. Ten clinical prediction scores were calculated and D-dimer levels were available for all patients. The gold standard was ultrasound diagnosis of DVT by an independent radiologist who was blinded to clinical records. For each prediction rule, we analyzed the effectiveness of the prediction strategy defined by "low clinical probability and negative D-dimer level" against the ultrasound diagnosis. RESULTS: A total of 861 case records were reviewed and 577 cases were selected; the mean (SD) age was 66.7 (14.2) years. DVT was diagnosed in 145 patients (25.1%). Only the Wells clinical prediction rule and 4 other models had a false negative rate under 2%. The Wells criteria and the score published by Johanning and colleagues identified higher percentages of cases (15.6% and 11.6%, respectively). CONCLUSION: This study shows that several clinical prediction rules can be safely used in the emergency department, although none of them have proven more effective than the Wells criteria.

OBJETIVO: Comparar la efectividad de los modelos clínicos más conocidos en combinación con el dímero D para la exclusión de un diagnóstico de trombosis venosa profunda (TVP) en un área de urgencias hospitalaria (AUH). METODO: Estudio retrospectivo de serie de casos con análisis transversal a partir de un registro que incluyó a todo paciente atendido por una sospecha clínica de TVP en miembros inferiores en un AUH entre los años 1998 y 2002. Se calcularon los 10 modelos clínicos y se determinó el dímero D a todos los pacientes. La prueba de referencia fue el diagnóstico de TVP realizado por parte de un radiólogo independiente y enmascarado a los datos clínicos mediante la realización de una ecografía. Se analizó la efectividad de la estrategia "baja probabilidad clínica y dímero D negativo" de cada modelo en relación a los resultados ecográficos obtenidos. RESULTADOS: Del total de 861 casos del registro, se seleccionaron 577 pacientes con una edad media de 66,7 (DE 14,2) años. Se realizó el diagnóstico de TVP en 145 pacientes (25,1%). Sólo el modelo de Wells y otros 4 modelos presentaron un porcentaje de falsos negativos inferior al 2%. De ellos, el modelo de Wells seguido del publicado por Johanning seleccionaron a un mayor porcentaje de pacientes (15,6% y 11,6%, respectivamente). CONCLUSIONES: El presente estudio muestra que existen diversos modelos clínicos que se pueden aplicar de forma segura en el ámbito de urgencias, aunque ninguno de ellos ha documentado ser más efectivo que la escala de Wells.

Utility-based early modulation of processing distracting stimulus information.

Humans are selective information processors who efficiently prevent goal-inappropriate stimulus information to gain control over their actions. Nonetheless, stimuli, which are both unnecessary for solving a current task and liable to cue an incorrect response (i.e., "distractors"), frequently modulate task performance, even when consistently paired with a physical feature that makes them easily discernible from target stimuli. Current models of cognitive control assume adjustment of the processing of distractor information based on the overall distractor utility (e.g., predictive value regarding the appropriate response, likelihood to elicit conflict with target processing). Although studies on distractor interference have supported the notion of utility-based processing adjustment, previous evidence is inconclusive regarding the specificity of this adjustment for distractor information and the stage(s) of processing affected. To assess the processing of distractors during sensory-perceptual phases we applied EEG recording in a stimulus identification task, involving successive distractor-target presentation, and manipulated the overall distractor utility. Behavioral measures replicated previously found utility modulations of distractor interference. Crucially, distractor-evoked visual potentials (i.e., posterior N1) were more pronounced in high-utility than low-utility conditions. This effect generalized to distractors unrelated to the utility manipulation, providing evidence for item-unspecific adjustment of early distractor processing to the experienced utility of distractor information.

Sequential modulation of distractor-interference produced by semantic generalization of stimulus features.

Sequential modulations of distractor-related interference (i.e., reduced congruency effect after incongruent as compared to congruent predecessor trials, a.k.a. Gratton effect) have been taken to reflect conflict-induced attentional focusing. To dismiss an alternative interpretation based on integration and retrieval of low-level features, it is important to exert experimental control of stimulus and response feature sequences. This has been achieved by considering only trials associated with complete feature changes. Furthermore, distractors from two different perceptual dimensions, such as stimulus location and shape, have been combined in the same experiment to investigate the question of specificity vs. generality of conflict adaptation. With this method feature sequence control can be exerted, in principle, without disregarding data from feature repetition trials. However, such control may be insufficient when the distractor dimensions overlap semantically. In two experiments we found evidence consistent with the assumption that semantic generalization of stimulus features, such as between a stimulus presented at a left-sided location and a stimulus shape pointing to the left, may yield a between-dimension Gratton effect. These findings raise doubts about inferring generalized attentional conflict adaptation when semantically related distractor dimensions are used.

Exploring conflict- and target-related movement of visual attention.

Intermixing trials of a visual search task with trials of a modified flanker task, the authors investigated whether the presentation of conflicting distractors at only one side (left or right) of a target stimulus triggers shifts of visual attention towards the contralateral side. Search time patterns provided evidence for lateral attention shifts only when participants performed the flanker task under an instruction assumed to widen the focus of attention, demonstrating that instruction-based control settings of an otherwise identical task can impact performance in an unrelated task. Contrasting conditions with response-related and response-unrelated distractors showed that shifting attention does not depend on response conflict and may be explained as stimulus-conflict-related withdrawal or target-related deployment of attention.

Conflict adjustment devoid of perceptual selection.

Task performance suffers when an aspect of a stimulus is associated with an incorrect response, thereby evoking cognitive conflict. Such impairment is reduced after recent or frequent conflict occurrence, suggesting attentional adjustment. We examined adjustment to conflict evoked by a temporarily irrelevant S-R rule when participants frequently switched between two semantic classification tasks by manipulating the proportion of conflict trials in one of them. Controlling stimulus-specific presentation frequencies, we found reduced conflict effects under conditions of a higher proportion of conflict trials in the task to which the manipulation was applied, whereas there was no such effect in the other task. Additional analyses demonstrated task-specificity regarding trial-to-trial conflict adjustment. Because conflict was evoked in the absence of perceptually distinct target and distractor stimulus features, these adjustment effects cannot be attributed to perceptual selection.

Sequential modulation of cue use in the task switching paradigm.

In task switching studies, pre-cuing of the upcoming task improves performance, indicating preparatory activation of the upcoming task-set, and/or inhibition of the previous task-set. To further investigate cue-based task preparation, the authors presented both valid and invalid task cues in a task switching experiment involving three tasks. Consistent with previous findings, a validity effect in terms of higher reaction times on invalidly compared to validly cued tasks was obtained. However, this validity effect was reduced following invalidly cued trials, suggesting dynamic adjustment in terms of decreased cue-based preparation after being misled. Performance was particularly impaired when the current task was the one that was invalidly cued on the preceding trial. This finding may reflect either particular reluctance to prepare or persisting inhibition of the erroneously prepared task-set from the pre-trial.

Conflict-induced perceptual filtering.

In a variety of conflict paradigms, target and distractor stimuli are defined in terms of perceptual features. Interference evoked by distractor stimuli tends to be reduced when the ratio of congruent to incongruent trials is decreased, suggesting conflict-induced perceptual filtering (i.e., adjusting the processing weights assigned to stimuli associated with the target and with the distractor features). In search of evidence for such a mechanism, we administered a flanker task, in which targets and distractors were defined in terms of stimulus location (Experiment 1) or color (Experiment 2). The efficiency of processing stimuli associated with target and distractor features was assessed in intermixed trials of a visual search task, in which a target had to be detected irrespective of these features. In both experiments search times were shorter for stimuli associated with the target feature than with the distractor feature of the flanker task. This effect was increased under conditions of a reduced congruent/incongruent ratio, thereby providing evidence for conflict-dependent perceptual filtering.

Conflict-frequency affects flanker interference: role of stimulus-ensemble-specific practiceand flanker-response contingencies.

Performance in choice reaction time tasks deteriorates when an irrelevant stimulus feature is associated with an incorrect response (conflict condition). Such interference effects are reduced under conditions of increased conflict-frequency. Although models of cognitive control account for this modulation in terms of conflict-related attentional focusing on the target stimulus dimension, it is possible that the effect reflects practice with specific stimulus ensembles or stimulus feature-response contingencies. Using an Eriksen flanker task, we deconfounded the frequency of conflict trials and the frequency of specific stimulus ensembles (i.e., target-flanker conjunctions). In Experiments 1 and 2, flanker interference varied inversely with the frequency of conflict trials, irrespective of practice with specific target-flanker conjunctions, thereby disputing a stimulus ensemble learning account. In Experiment 3, however, flanker interference was reduced for specific flanker stimuli which occurred predominantly in conflict trials. Taken together, the findings are consistent with flanker-specific attentional adjustment or associative flanker-response priming.

Response selection difficulty and asymmetrical costs of switching between tasks and stimuli: no evidence for an exogenous component of task-set reconfiguration.

Four task-switching experiments examined the notion of an exogenous component of task-set reconfiguration (i.e., a process needed to shift task set that is not initiated in the absence of a task-associated figuration stimulus). The authors varied the complexity and familiarity of stimulus-response (SR) mapping rules to produce differentially time-consuming reconfiguration demands. Tasks with more complex or less familiar rules did not display increased switch costs, given that stimulus repetitions were excluded from the analysis. These results do not support the idea of exogenous reconfiguration. Moreover, stimulus repetitions inflated task-switch costs and did so disproportionately for tasks with increased response selection difficulty, thereby demonstrating that insufficient control of the sequence of stimuli may yield results that mimic those predicted by exogenous reconfiguration accounts.