Characterization of the Sublimation and Vapor Pressure of 2-(2-Nitrovinyl) Furan (G-0) Using Thermogravimetric Analysis: Effects of Complexation with Cyclodextrins.

In the present work, the sublimation of crystalline solid 2-(2-nitrovinyl) furan (G-0) in the temperature range of 35 to 60 °C (below the melting point of the drug) was studied using thermogravimetric analysis (TGA). The sublimated product was characterized using Fourier-transformed-infrared spectroscopy (FT-IR) and thin layer chromatography (TLC). The sublimation rate at each temperature was obtained using the slope of the linear regression model and followed apparent zero-order kinetics. The sublimation enthalpy from 35 to 60 °C was obtained from the Eyring equation. The Gückel method was used to estimate the sublimation rate and vapor pressure at 25 °C. Physical mixtures, kneaded and freeze-dried complexes were prepared with 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD) and sulfobutyl ether-ß-cyclodextrin (SBE-ß-CD) and analyzed using isothermal TGA at 50 °C. The complexation contributed to reducing the sublimation process. The best results were achieved using freeze-dried complexes with both cyclodextrins.

Caracterización de los pacientes ventilados por traumatismo craneoencefálico grave / Description of Patients with Severe Craniocephalic Trauma Treated by Mechanical Ventilation

Se realizó un estudio descriptivo prospectivo de una serie de casos en la Unidad de Cuidados Intensivos del Hospital General Universitario Vladimir Ilich Lenin de Holguín desde febrero de 2008 hasta noviembre de 2009, con el objetivo de caracterizar la morbilidad y mortalidad de los pacientes ventilados por traumatismo craneoencefálico grave. El universo incluyó a todos los pacientes ingresados en dicha sala por trauma craneoencefálico grave y la muestra estuvo conformada por 43 pacientes que sobrevivieron por más de 48 h y aceptaron participar en el estudio...(AU)

A series of cases descriptive and prospective research, at Intensive Care Unit from Vladimir Ilich Lenin Hospital (February 2008 - November 2009) was done, aimed at describing the morbidity and mortality in patients with severe craniocephalic trauma and treated by mechanical ventilation. The universe included all hospitalized patients and 43 of them represented the sample who survived for more than 48 hours and accepted to take part of this study. A relation between age and sex was established by using Glasgow scale taking into account hospital admission and departure...(AU)