Amivantamab plus lazertinib versus osimertinib in first-line EGFR-mutant advanced non-small-cell lung cancer with biomarkers of high-risk disease: a secondary analysis from MARIPOSA.

BACKGROUND: Amivantamab-lazertinib significantly prolonged progression-free survival (PFS) versus osimertinib in patients with epidermal growth factor receptor (EGFR)-mutant advanced non-small-cell lung cancer [NSCLC; hazard ratio (HR) 0.70; P < 0.001], including those with a history of brain metastases (HR 0.69). Patients with TP53 co-mutations, detectable circulating tumor DNA (ctDNA), baseline liver metastases, and those without ctDNA clearance on treatment have poor prognoses. We evaluated outcomes in these high-risk subgroups. PATIENTS AND METHODS: This analysis included patients with treatment-naive, EGFR-mutant advanced NSCLC randomized to amivantamab-lazertinib (n = 429) or osimertinib (n = 429) in MARIPOSA. Pathogenic alterations were identified by next-generation sequencing (NGS) of baseline blood ctDNA with Guardant360 CDx. Ex19del and L858R ctDNA in blood was analyzed at baseline and cycle 3 day 1 (C3D1) with Biodesix droplet digital polymerase chain reaction (ddPCR). RESULTS: Baseline ctDNA for NGS of pathogenic alterations was available for 636 patients (amivantamab-lazertinib, n = 320; osimertinib, n = 316). Amivantamab-lazertinib improved median PFS (mPFS) versus osimertinib for patients with TP53 co-mutations {18.2 versus 12.9 months; HR 0.65 [95% confidence interval (CI) 0.48-0.87]; P = 0.003} and for patients with wild-type TP53 [22.1 versus 19.9 months; HR 0.75 (95% CI 0.52-1.07)]. In patients with EGFR-mutant, ddPCR-detectable baseline ctDNA, amivantamab-lazertinib significantly prolonged mPFS versus osimertinib [20.3 versus 14.8 months; HR 0.68 (95% CI 0.53-0.86); P = 0.002]. Amivantamab-lazertinib significantly improved mPFS versus osimertinib in patients without ctDNA clearance at C3D1 [16.5 versus 9.1 months; HR 0.49 (95% CI 0.27-0.87); P = 0.015] and with clearance [24.0 versus 16.5 months; HR 0.64 (95% CI 0.48-0.87); P = 0.004]. Amivantamab-lazertinib significantly prolonged mPFS versus osimertinib among randomized patients with [18.2 versus 11.0 months; HR 0.58 (95% CI 0.37-0.91); P = 0.017] and without baseline liver metastases [24.0 versus 18.3 months; HR 0.74 (95% CI 0.60-0.91); P = 0.004]. CONCLUSIONS: Amivantamab-lazertinib effectively overcomes the effect of high-risk features and represents a promising new standard of care for patients with EGFR-mutant advanced NSCLC.

Prevalencia de síndrome metabólico en población laboral. El corazón de Asepeyo / Prevalence of metabolic syndrome (MS) in laboral population. The heart of Asepeyo

Introducción: El espectacular aumento que el síndrome metabólico (SM) está teniendo en las sociedades occidentales, conduce inevitablemente al incremento de la enfermedad cardiovascular. Por ello y puesto que su presencia indica la necesidad de aplicar medidas activas para reducir el riesgo cardiovascular, nos propusimos estudiar la prevalencia del síndrome metabólico y los factores de riesgo asociados a él, en nuestra población laboral. Material y métodos: El estudio incluyó 345 trabajadores, 191 mujeres y 154 hombres, sometidos a un reconocimiento laboral durante el año 2006. Resultados: El 12,5 % de la población presentó obesidad, siendo esta mayor en hombres (16,9%) que en mujeres (8,9%). La prevalencia de SM fue del 7,8%, siendo mayor en hombres que en mujeres. El 57,7% de los hombres y el 29,4% de las mujeres con obesidad presentaban SM. Los trabajadores con más edad, tuvieron mayor prevalencia de SM. El criterio de SM más prevalente fue la hipertensión arterial. Todos los criterios de SM predominaron en varones a excepción del perímetro abdominal, que lo hizo en las mujeres. Conclusiones:1. Casi 8 de cada 100 trabajadores presentaron SM, siendo mayor la prevalencia en los varones. La obesidad aumentó de forma importante la prevalencia de SM. Los trabajadores con más edad, tuvieron mayor prevalencia de SM.2. El perímetro abdominal se asoció significativamente con todos los factores de riesgo relacionados con el SM con excepción de la glucosa elevada en los hombres

Background: The high increase of the metabolic syndrome (MS) on the occidental World, is increasing the cardiovascular disease. Since, as the presence of metabolic syndrome suggests the application of preventive measure neccesary, We studied, the prevalence of metabolic syndrome and the cardiovascular risk factors (RF) in our laboral population. Methods: The sample included 345 workers, 191 females and 154 males. All the people passed a laboral chec-up at the year 2006. Results: Obesity was presented in 12.5% of the sample, 16.9% inmales, 8.9% in females. The prevalence of MS was 7.8%, being higher inmales than in females. 57.7% of obeses males presented MS and 29.4% of obeses females presented MS. The older worker presented higher prevalence of MS. The high blood pressure was the factor more prevalent, in worker with MS. All the factors of MS were more pevalent inmales, to exception of waist circumference.Conclusions:1. Almost 8% of workers presented MS, being higher the prevalance in males. The obesity increased of important manner the MS. The older worker had higher prevalence of MS.2. The waist circumference associated with all the FR related with MS

[Prevalence of metabolic syndrome (MS) in laboral population. The heart of Asepeyo]. / Prevalencia de síndrome metabólico en población laboral: El corazón de Asepeyo.

BACKGROUND: The high increase of the metabolic syndrome (MS) on the occidental World, is increasing the cardiovascular disease. Since, as the presence of metabolic syndrome suggests the application of preventive measure necessary, We studied, the prevalence of metabolic syndrome and the cardiovascular risk factors (RF) in our laboral population. METHODS: The sample included 345 workers, 191 females and 154 males. All the people passed a laboral check-up at the year 2006. RESULTS: Obesity was presented in 12.5% of the sample, 16.9% in males, 8.9% in females. The prevalence of MS was 7.8%, being higher in males than in females. 57.7% of obese males presented MS and 29.4% of obese females presented MS. The older worker presented higher prevalence of MS. The high blood pressure was the factor more prevalent, in worker with MS. All the factors of MS were more prevalent in males, to exception of waist circumference. CONCLUSIONS: 1. Almost 8% of workers presented MS, being higher the prevalence in males. The obesity increased of important manner the MS. The older worker had higher prevalence of MS. 2. The waist circumference associated with all the FR related with MS.