RESUMO
Introducción: larva migrans cutánea, es una zoonosis parasitaria causada por la penetración y migración a través de la piel de larvas de nematodos, adquiridos por contacto corporal con tierra, arena y materiales de construcción contaminados con heces de perros y gatos infestados. Objetivo: identificar correctamente el diagnóstico clínico de larva migrans cutánea en pacientes con sospecha de la enfermedad y contribuir a su mejor manejo. Caso clínico: paciente de 14 años de edad con lesiones serpiginosas en ambos miembros inferiores, y región glútea, acompañadas de dolor local intenso, prurito e irritabilidad. El diagnóstico se realizó mediante la clínica y los antecedentes epidemiológicos, se le aplicó como tratamiento antiparasitario el tiabendazol con una evolución satisfactoria del paciente.
Introduction: cutaneous larva migrans is a parasitic zoonosis caused by the penetration and migration through the skin of nematodes larvae, acquired by corporal contact with earth, sand and polluted construction materials infested with excrements of dogs and cats. Objective: to identify correctly the clinical diagnosis of cutaneous larva migrans in patients with suspicion of the disease and to contribute to their best handling. Clinical Case: a 14 year-old patient with serpiginous lesions in both inferior limbs and in the gluteal region, accompanied by local intense pain, pruritus and irritability. The diagnosis was carried out by means of the clinic and the epidemical antecedents. The patient was administered the thiabendazole as part of the antiparasitic treatment with satisfactory outcomes.
RESUMO
Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) induced maturation of bone marrow-derived dendritic cells (DCs) of wild-type (WT) C57BL/6 mice as evidenced by an increase in surface expression of MHC class I and II molecules and costimulatory molecules such as CD40, CD80, and CD86. Functionally, decreased phagocytic ability and increased alloreactive T cell stimulatory ability were observed in T.g.HSP70-stimulated DCs. These phenotypic and functional changes of T.g.HSP70-stimulated DCs were demonstrated in Toll-like receptor (TLR) 2- and myeloid differentiation factor 88 (MyD88)-deficient but not TLR4-deficient C57BL/6 mice. DCs from WT and TLR2-deficient but not TLR4-deficient mice produced IL-12 after T.g.HSP70 stimulation. T.g.HSP70-stimulated DCs from WT, TLR2-deficient, and MyD88-deficient, but not TLR4-deficient mice expressed IFN-beta mRNA. Thus, T.g.HSP70 stimulates murine DC maturation via TLR4 through the MyD88-independent signal transduction cascade.