RESUMO
OBJECTIVE: First, to assess what was the uptake of cell free DNA (cfDNA) testing after a combined test and the maternal and fetal factors that influenced this decision, and second, to assess the uptake and factors that influence the choice of invasive testing. METHODS: This observational retrospective study included 1083 singleton pregnancies who had a combined test for screening for Down syndrome between 11 (+) (0) and 13 (+) (6) weeks. Multivariate logistic regression analysis was used to determine which factors affected the uptake of cfDNA test and invasive testing among risk for trisomies 21, 18, and 13, maternal characteristics and fetal nuchal translucency (NT) thickness. RESULTS: Two-hundred fifty-seven (23.7%) women had a cfDNA test, 89 (8.2%) had an invasive test, and 737 (68.1%) had no further test. The uptake of cfDNA increased with the risk for trisomies (p < 0.001), maternal age (p = 0.013), and was higher in nulliparous women (p = 0.004). The uptake of invasive test increased with the risk for trisomies (p < 0.001) and NT thickness (p < 0.001). CONCLUSIONS: This study shows that the uptake of cfDNA testing increases with the risk for trisomies, maternal age, and is higher in nulliparous, whereas the uptake of invasive testing increases with the risk for trisomies and NT thickness.
Assuntos
Biomarcadores/sangue , Comportamento de Escolha , DNA/sangue , Síndrome de Down/genética , Diagnóstico Pré-Natal/métodos , Adolescente , Adulto , Sistema Livre de Células , Síndrome de Down/sangue , Síndrome de Down/diagnóstico , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Gravidez , Diagnóstico Pré-Natal/efeitos adversos , Diagnóstico Pré-Natal/psicologia , Análise de Regressão , Estudos Retrospectivos , Medição de Risco , Adulto JovemRESUMO
La torsión tubárica es un proceso muy infrecuente, aunque hay casos descritos en mujeres de cualquier edad y en diversas situaciones. Los casos más frecuentes son los producidos en mujeres en edad fértil tras un proceso de esterilización tubárica, ya que el frecuente hidrosalpinx posquirúrgico predispone a este desenlace. El diagnóstico habitualmente se realiza tarde, en el momento de la cirugía, es decir, tras necrosis y posterior salpinguectomía
Fallopian tube torsion is a very uncommon event, even though many cases have been described in all ages and in a wide range of situations. This entity most frequently occurs in women of fertile age after tubal sterilization, because postsurgical hydrosalpinx is a predisposing factor. Diagnosis is often made late, at the moment of surgery, with a finding of tubal necrosis. Usually, salpingectomy is subsequently performed
