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1.
Neurología (Barc., Ed. impr.) ; 38(9): 671-680, Nov-Dic. 2023. ilus
Artigo em Espanhol | IBECS | ID: ibc-227351

RESUMO

Introducción: Los rafts constituyen nano-dominios estructurales de naturaleza lipoproteica que propician la eficiente transducción de señales y la modulación de procesos fisiológicos asociados a la membrana plasmática. En el sistema nervioso, la alteración de estos dominios se ha asociado con el desarrollo de diversos padecimientos. Desarrollo: En el presente artículo se revisa el concepto de rafts, los procesos del sistema nervioso en los cuales están involucrados y su papel en distintas afectaciones, entre las que se destacan las enfermedades de Parkinson, Alzheimer y Huntington. Conclusiones: Dadas las evidencias de su participación en diversas neuropatologías, la preservación y/o reconstitución de los rafts se vislumbran como una atractiva estrategia terapéutica.(AU)


Introduction: Rafts are function-structural cell membrane nano-domains. They contribute to explain the efficiency of signal transduction at the low physiological membrane concentrations of the signaling partners by their clustering inside specialized signaling domains. Development: In this article, we review the current model of the membrane rafts and their physio-pathological relevance in the nervous system, including their role in Parkinson, Alzheimer, and Huntington diseases. Conclusions: Rafts disruption/dysfunction has been shown to relate diverse neurological diseases. Therefore, it has been suggested that preservation of membrane rafts may represent a strategy to prevent or delay neuronal dysfunctions in several diseases.(AU)


Assuntos
Humanos , Masculino , Feminino , Sistema Nervoso , Doença de Parkinson , Doença de Alzheimer , Doença de Huntington , Membrana Celular , Neurologia , Doenças do Sistema Nervoso , Cavéolas , Colesterol
2.
Neurologia (Engl Ed) ; 38(9): 671-680, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37858892

RESUMO

INTRODUCTION: Rafts are protein-lipid structural nanodomains involved in efficient signal transduction and the modulation of physiological processes of the cell plasma membrane. Raft disruption in the nervous system has been associated with a wide range of disorders. DEVELOPMENT: We review the concept of rafts, the nervous system processes in which they are involved, and their role in diseases such as Parkinson's disease, Alzheimer disease, and Huntington disease. CONCLUSIONS: Based on the available evidence, preservation and/or reconstitution of rafts is a promising treatment strategy for a wide range of neurological disorders.


Assuntos
Doença de Alzheimer , Cavéolas , Humanos , Cavéolas/química , Cavéolas/metabolismo , Microdomínios da Membrana/química , Microdomínios da Membrana/metabolismo , Colesterol/análise , Colesterol/química , Colesterol/metabolismo , Membrana Celular/metabolismo
3.
Neurologia (Engl Ed) ; 2021 Mar 13.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33726969

RESUMO

INTRODUCTION: Rafts are function-structural cell membrane nano-domains. They contribute to explain the efficiency of signal transduction at the low physiological membrane concentrations of the signaling partners by their clustering inside specialized signaling domains. DEVELOPMENT: In this article, we review the current model of the membrane rafts and their physio-pathological relevance in the nervous system, including their role in Parkinson, Alzheimer, and Huntington diseases. CONCLUSIONS: Rafts disruption/dysfunction has been shown to relate diverse neurological diseases. Therefore, it has been suggested that preservation of membrane rafts may represent a strategy to prevent or delay neuronal dysfunctions in several diseases.

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