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J Pediatr Hematol Oncol ; 40(2): e108-e110, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-28859036

RESUMO

Hemophagocytic lymphohistiocytosis (HLH) is a condition caused by a pathologic immune activation, which is responsible for its signs and symptoms. It may also appear as a secondary process caused by malignancy. Developing HLH during treatment for acute lymphoblastic leukemia (ALL) is extremely uncommon, but underdiagnosis may be fatal. Two patients with ALL on chemotherapy maintenance treatment who developed HLH triggered by infection are presented here. We emphasize the importance of being aware of this condition when a patient with ALL in complete remission presents with unexplained hepatomegaly, cytopenia, and fever. Early diagnosis and treatment may be lifesaving.


Assuntos
Hospedeiro Imunocomprometido , Infecções/imunologia , Linfo-Histiocitose Hemofagocítica/imunologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Antineoplásicos/efeitos adversos , Criança , Feminino , Humanos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
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