RESUMO
A case of a term newborn infant with a congenital Wilm's tumor who developed severe jaundice and consumption coagulopathy is reported. After the removal of the tumor, the clotting factors became normal and the jaundice resolved. It is suggested that there was an association between the presence of the tumor and hemolysis and consumption coagulopathy.
Assuntos
Coagulação Intravascular Disseminada/etiologia , Icterícia Neonatal/etiologia , Neoplasias Renais/congênito , Tumor de Wilms/congênito , Humanos , Recém-Nascido , Neoplasias Renais/complicações , Neoplasias Renais/cirurgia , Masculino , Tumor de Wilms/complicações , Tumor de Wilms/cirurgiaRESUMO
Guinea pig hearts isolated by the Langendorff technique were perfused with a nitro-blue tetrazolium salt solution. In spite of a homogeneous dark-blue staining at the macroscopic examination, light-microscopic studies showed a spotty staining of the myocardial fibers. Since no microscopic alterations were found which could explain the unstained areas, ultramicroscopic studies were undertaken. At ultrastructural level, striking alterations of myocardial cells were observed. They consisted of mitochondrial lesions, alterations of the transversal tubuli, and intercalated discs. Arteriolar narrowing and capillary edema were found, suggesting that pathological changes in the microcirculation could be a possible reason for the spotty staining of the myocardial fibers. Some speculations on the nature and localization of the formazan granules are also reported.
Assuntos
Doença das Coronárias/patologia , Miocárdio/patologia , Nitroazul de Tetrazólio , Sais de Tetrazólio , Animais , Vasos Coronários/ultraestrutura , Cobaias , Microscopia Eletrônica , Mitocôndrias/ultraestrutura , Coloração e RotulagemRESUMO
Comparative histochemical studies with Tetrazolium salt solutions were performed on 25 human and 3 canine hearts. After perfusion of whole hearts with Tetrazolium solutions extensive unstained areas were observed which proved to be artefacts, since they reacted positively after incubation of the heart-slices. The perfusion method of Lichtig, Feldman, Glagov and Wissler (1973) which was proposed for macroscopic and microscopic diagnosis of ischemic cardiac lesions was not found to be suitable for the identification of microcirculatory disturbances. The usual incubation method, however, proved to be useful for the macroscopic localization of recent myocardial infarcts.
