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1.
J Infect Dis ; 222(8): 1311-1319, 2020 09 14.
Artigo em Inglês | MEDLINE | ID: mdl-32484879

RESUMO

BACKGROUND: During 2017, a multistate outbreak investigation occurred after the confirmation of Seoul virus (SEOV) infections in people and pet rats. A total of 147 humans and 897 rats were tested. METHODS: In addition to immunoglobulin (Ig)G and IgM serology and traditional reverse-transcription polymerase chain reaction (RT-PCR), novel quantitative RT-PCR primers/probe were developed, and whole genome sequencing was performed. RESULTS: Seventeen people had SEOV IgM, indicating recent infection; 7 reported symptoms and 3 were hospitalized. All patients recovered. Thirty-one facilities in 11 US states had SEOV infection, and among those with ≥10 rats tested, rat IgG prevalence ranged 2%-70% and SEOV RT-PCR positivity ranged 0%-70%. Human laboratory-confirmed cases were significantly associated with rat IgG positivity and RT-PCR positivity (P = .03 and P = .006, respectively). Genomic sequencing identified >99.5% homology between SEOV sequences in this outbreak, and these were >99% identical to SEOV associated with previous pet rat infections in England, the Netherlands, and France. Frequent trade of rats between home-based ratteries contributed to transmission of SEOV between facilities. CONCLUSIONS: Pet rat owners, breeders, and the healthcare and public health community should be aware and take steps to prevent SEOV transmission in pet rats and to humans. Biosecurity measures and diagnostic testing can prevent further infections.


Assuntos
Surtos de Doenças , Febre Hemorrágica com Síndrome Renal/transmissão , Doenças dos Roedores/transmissão , Vírus Seoul/isolamento & purificação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Cruzamento , Criança , Pré-Escolar , Técnicas de Laboratório Clínico/veterinária , Surtos de Doenças/veterinária , Genoma Viral/genética , Febre Hemorrágica com Síndrome Renal/diagnóstico , Febre Hemorrágica com Síndrome Renal/epidemiologia , Humanos , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Lactente , Pessoa de Meia-Idade , Animais de Estimação/virologia , Filogenia , Prevalência , RNA Viral/genética , Ratos , Doenças dos Roedores/diagnóstico , Doenças dos Roedores/epidemiologia , Vírus Seoul/classificação , Vírus Seoul/genética , Vírus Seoul/imunologia , Estados Unidos/epidemiologia , Zoonoses Virais/diagnóstico , Zoonoses Virais/epidemiologia , Zoonoses Virais/transmissão , Adulto Jovem
2.
Exp Clin Psychopharmacol ; 18(2): 120-8, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20384423

RESUMO

Research indicates that nicotine and alcohol are often used on the same occasion. However, the reasons for their concurrent use are not well understood. We hypothesized that one reason smokers use tobacco when they drink alcohol is to compensate for alcohol's negative effects on processing capacity with nicotine's enhancement of processing capacity. As such, the present study tested this theory by using an independent groups design to examine the separate and combined acute effects of alcohol and nicotine on working memory (WM) capacity. Nonabstinent daily smokers (n = 127) performed the counting span task (CSPAN) after consuming either an alcohol (men: 0.8 g/kg; women: 0.7 g/kg) or placebo beverage and smoking either nicotinized (1.14 mg nicotine, 15.9 mg tar) or denicotinized (.06 mg nicotine, 17.9 mg tar) cigarettes. Analyses revealed that smokers who smoked the nicotinized cigarettes performed significantly worse on the CSPAN task than smokers who smoked the denicotinized cigarettes. Although there was no main effect of alcohol on WM performance, women exhibited better WM performance than men after consuming alcohol whereas men performed better than women on the WM task after consuming the placebo beverage. Findings also revealed no interaction between the two substances on WM performance. Taken together, results suggest that nicotine impairs nonabstinent smokers' verbal WM capacity and that gender moderates the effects of alcohol on WM. Furthermore, the present findings failed to support the notion that nicotine compensates for alcohol-related decrements in working memory capacity.


Assuntos
Interações Medicamentosas , Etanol/farmacologia , Memória de Curto Prazo/efeitos dos fármacos , Nicotina/farmacologia , Fumar/psicologia , Adulto , Intoxicação Alcoólica/psicologia , Testes Respiratórios , Monóxido de Carbono/análise , Etanol/sangue , Feminino , Humanos , Masculino , Placebos , Desempenho Psicomotor/efeitos dos fármacos , Caracteres Sexuais
3.
Child Dev ; 78(1): 279-95, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17328705

RESUMO

Stress exposure and reactivity models were examined as explanations for why girls exhibit greater levels of depressive symptoms than boys. In a multiwave, longitudinal design, adolescents' depressive symptoms, alcohol usage, and occurrence of stressors were assessed at baseline, 6, and 12 months later (N=538; 54.5% female; ages 13-18, average 14.9). Daily stressors were coded into developmentally salient domains using a modified contextual-threat approach. Girls reported more depressive symptoms and stressors in certain contexts (e.g., interpersonal) than boys. Sex differences in depression were partially explained by girls reporting more stressors, especially peer events. The longitudinal direction of effects between depression and stressors varied depending on the stressor domain. Girls reacted more strongly to stressors in the form of depression.


Assuntos
Depressão/psicologia , Caracteres Sexuais , Estresse Psicológico/complicações , Adolescente , Consumo de Bebidas Alcoólicas/epidemiologia , Consumo de Bebidas Alcoólicas/psicologia , Chicago , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , Controle Interno-Externo , Relações Interpessoais , Estudos Longitudinais , Masculino , Grupo Associado , Estudos Prospectivos , Fumar/epidemiologia , Fumar/psicologia
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