Differential Behavioral and Neural Profiles in Youth With Conduct Problems During Risky Decision-Making.

Neuroimaging work has examined neural processes underlying risk taking in adolescence, yet predominantly in low-risk youth. To determine whether we can extrapolate from current neurobiological models, this functional magnetic resonance imaging study investigated risk taking and peer effects in youth with conduct problems (CP; N = 19) and typically developing youth (TD; N = 25). Results revealed higher real-life risk taking, lower risky decisions, and no peer effects on a risk-taking task in CP youth. CP youth showed greater ventral striatum (VS) activity during safe than risky decisions, whereas TD youth showed greater VS activation during risky decisions. Differential VS activity explained higher real-life risk taking in CP youth. Findings provide preliminary evidence that risk-taking behavior in youth with CD problems is characterized by differential neural patterns.

Maternal Buffering of Adolescent Dysregulation in Socially Appetitive Contexts: From Behavior to the Brain.

Adolescents are more susceptible to dysregulation in positive social contexts, compared to children. We investigated whether maternal presence would buffer these effects in adolescence. Fifty-four adolescents and children (age range = 8-17 years, Mage  = 13.38 years) completed a social go-nogo task during an fMRI scan alone and in the presence of their mother. We found age-related patterns, such that older relative to younger youth displayed more disinhibition toward socially appetitive than socially aversive stimuli, which was buffered by maternal presence. Furthermore, with age, maternal buffering in socially appetitive contexts elicited heightened activation in the ventromedial prefrontal cortex and amygdala-medial prefrontal cortex connectivity. Findings underscore the importance of caregivers in promoting the neural regulation of their offspring during adolescence.

Neural correlates of sibling closeness and association with externalizing behavior in adolescence.

Sibling relationships have been linked to adolescent externalizing behaviors, but the neurobiological factors that underlie this association have not been identified. This study investigated sibling closeness and birth order as a predictor of adolescent externalizing behavior via differences in neural processes during safe decision-making. A total of 77 adolescents (range = 12-15 years, Mage = 13.45 years, 40 females) completed a computerized driving task during a functional MRI scan. Results showed that adolescents' perceptions of sibling closeness were associated with greater neural activation in the anterior insula, ventral striatum and left ventrolateral prefrontal cortex when making safe decisions, suggesting that the quality of sibling relationships modulates adolescent neurocognition even without being present. Furthermore, moderated mediation analyses revealed that higher sibling closeness was associated with lower externalizing behavior via left anterior insula activation during safe decision-making, but only for adolescents without older siblings (i.e. eldest children) compared to adolescents who had multiple older siblings. Importantly, these findings persisted above and beyond parental and peer closeness and sibling characteristics (i.e. sex, relatedness, birth order), highlighting the significant influence of sibling relationships on adolescent externalizing behavior through the brain.

Differential effects of parent and peer presence on neural correlates of risk taking in adolescence.

Adolescence is a developmental period associated with increased health-risk behaviors and unique sensitivity to the input from the social context, paralleled by major changes in the developing brain. Peer presence increases adolescent risk taking, associated with greater reward-related activity, while parental presence decreases risk taking, associated with decreased reward-related activity and increased cognitive control. Yet the effects specific to peers and parents are still unknown. The current functional magnetic resonance imaging (fMRI) study compared within-person peer and parent influences on risky decision-making during adolescence (ages 12-15 years; N = 56). Participants completed the Yellow Light Game (YLG), a computerized driving task, during which they could make safe or risky decisions, in the presence of a peer and their parent. Behavioral findings revealed no effects of social context on risk taking. At the neural level, a collection of affective, social and cognitive regions [ventral striatum (VS), temporo-parietal junction (TPJ), and dorsolateral prefrontal cortex (dlPFC)] was more active during decision-making with peers than parents. Additionally, functional connectivity analyses showed greater coupling between affective, social and cognitive control regions (VS-insula, VS-TPJ) during decision-making with parents than peers. These findings highlight the complex nature of social influence processes in peer and parent contexts, and contribute to our understanding of the opportunities and vulnerabilities associated with adolescent social sensitivity.

Social Influence on Positive Youth Development: A Developmental Neuroscience Perspective.

Susceptibility to social influence is associated with a host of negative outcomes during adolescence. However, emerging evidence implicates the role of peers and parents in adolescents' positive and adaptive adjustment. Hence, in this chapter we highlight social influence as an opportunity for promoting social adjustment, which can redirect negative trajectories and help adolescents thrive. We discuss influential models about the processes underlying social influence, with a particular emphasis on internalizing social norms, embedded in social learning and social identity theory. We link this behavioral work to developmental social neuroscience research, rooted in neurobiological models of decision making and social cognition. Work from this perspective suggests that the adolescent brain is highly malleable and particularly oriented toward the social world, which may account for heightened susceptibility to social influences during this developmental period. This chapter underscores the need to leverage social influences during adolescence, even beyond the family and peer context, to promote positive developmental outcomes. By further probing the underlying neural mechanisms as an additional layer to examining social influence on positive youth development, we will be able to gain traction on our understanding of this complex phenomenon.

Do Hostile School Environments Promote Social Deviance by Shaping Neural Responses to Social Exclusion?

The present study examined adolescents' neural responses to social exclusion as a mediator of past exposure to a hostile school environment (HSE) and later social deviance, and whether family connectedness buffered these associations. Participants (166 Mexican-origin adolescents, 54.4% female) reported on their HSE exposure and family connectedness across Grades 9-11. Six months later, neural responses to social exclusion were measured. Finally, social deviance was self-reported in Grades 9 and 12. The HSE-social deviance link was mediated by greater reactivity to social deviance in subgenual anterior cingulate cortex, a region from the social pain network also implicated in social susceptibility. However, youths with stronger family bonds were protected from this neurobiologically mediated path. These findings suggest a complex interplay of risk and protective factors that impact adolescent behavior through the brain.

Developmental Change in Sibling Support and School Commitment Across Adolescence.

School commitment typically declines across adolescence, but the family-level factors that explain this decline have not been fully characterized. This study investigated sibling support as a family resource in predicting school commitment across 7th-10th grade using a sample of 444 adolescents (Mages  = 12.61, 13.59, 14.59, 15.58 years). Results showed that sibling support linearly increased and school commitment decreased and stabilized, independently, over time. Sibling support positively predicted school commitment in seventh grade and across time, suggesting that having supportive siblings may help to offset adolescents' declines in school commitment. Furthermore, having a brother enhanced this association versus having a sister. These findings provide insight into ways to help youth maintain school commitment across the middle- to high school transition.

Neural Correlates of Social Influence on Risk Taking and Substance Use in Adolescents.

PURPOSE OF REVIEW: Adolescents often engage in elevated levels of risk taking that gives rise to substance use. Family and peers constitute the primary contextual risk factors for adolescent substance use. This report reviews how families and peers influence adolescent neurocognitive development to inform their risk taking and subsequent substance use. RECENT FINDINGS: Developmental neuroscience using functional magnetic resonance imaging (fMRI) has identified regions of the brain involved in social cognition, cognitive control, and reward processing that are integrally linked to social influence on adolescent risk taking. These neural mechanisms play a role in how peer and family influence (e.g., physical presence, relationship quality, rejection) translates into adolescent substance use. SUMMARY: Peers and families can independently, and in tandem, contribute to adolescent substance use, for better or for worse. We propose that future work utilize fMRI to investigate the neural mechanisms involved in different aspects of peer and family influence, and how these contexts uniquely and interactively influence adolescent substance use initiation and escalation across development.