[Thyroid gland function after therapy of the laryngeal cancer: prospective examinations]. / Funkcja hormonalna tarczycy po leczeniu raka krtani--badania prospektywne.

The paper presents the results of the study concerning thyroid gland function of the patients suffering from larynx cancer treated with: a) surgery only (n = 31), b) surgery with further radiotherapy with radical doses 5400-7000 cGy (n = 44), c) radiotherapy along with radical doses 6400-7000 cGy (n = 7). 82 patients (M-73, F-9) were examined. Average age was 58 (min. 30, max. 80). Thyroid gland function was evaluated by measurement of: a) hTSH, fT3, fT4, b) serum lipids concentration. The examinations mentioned above were performed before as well as after the treatment at: a) 1, b) 1-6, c) 6-12, d) 12-24, e) longer than 24 months after completion of treatment. The longest period of observation involved 8 years. Our results show that hypothyroidism (mostly subclinical) occurs seldom (6% of all the cases) in the early phase (up to 1 month) after surgical treatment. After radiotherapy only--no subclinical hypothyroidism was observed. The combined treatment seems to be the most frequent cause of subclinical hypothyroidism. Its frequency increases (up to 27%) with the length of time since the conclusion of treatment. We also tried to explain the pathogenesis of subclinical hypothyroidism on the basis of histopathologic examination of thyroid tissue (n = 13) derived from the patients after various ways of treatment. The studies were compared to the results of histological examinations of the thyroid sections obtained during autopsy (n = 20) from the control group (not suffered from thyroid diseases).

[Hormonal function of the thyroid gland after therapy for laryngeal cancer]. / Funkcja hormonalna tarczycy po leczeniu raka krtani.

The paper presents the results of the study concerning thyroid gland function of the patients suffering from larynx cancer treated with: a) surgery only, b) surgery with further radiotherapy with radical doses 5000-6500 cGy, c) radiotherapy along with radical doses 6500-7200 cGy. Thyroid gland function was evaluated by measurement of: a) hTSH, FT3, FT4, b) serum lipids concentration. The hTSH concentration was evaluated by immunoradiometric method whereas FT3 and FT4 by DELFIA techniques (deleted fluorescence). 162 patients (M-148, F-14) were examined. Average age was 57 (min.-30, max.-80). The patients were divided into two groups. The first group (n = 90) involved those who had been examined once at different time since the end of treatment (retrospective examinations). The patients who had been examined before as well as after treatment were established as the second group (n = 72) (prospective examinations). In this case the examinations are still being continued and they are carried out at: a) 1, b) 1-6, c) 6-12, d) 12-24, e) longer than 24 months after completion of treatment. Our preliminary data show that hypothyroidism (mostly subclinical) occurs seldom (7% of all the cases) in the early phase (up to 1 month) after surgical treatment and gets normal spontaneously (up to 6 months). After radiotherapy only--no subclinical hypothyroidism was observed. Interestingly, the combined treatment seems to be the most frequent cause of subclinical hypothyroidism. Its frequency increases (up to 47%) with the length of time since the conclusion of treatment (2 years and longer). Because of continuation of our examinations the presented data are still preliminary and they will be verified in the next paper. We also tried to explain the pathogenesis of subclinical hypothyroidism on the basis of histopathologic examination of thyroid tissue derived from the patients (after combined treatment and after radiotherapy) during further total laryngectomy performed because of neoplasm renewal.

[The results of radiation and surgical treatment of early vocal cord carcinoma (T1a, T1b)]. / Wyniki radioterapii i chirurgicznego leczenia wczesnych raków faldów glosowych (T1a, T1b).

Results of surgery treatment from the external access and radiotherapy in early, stage of vocal cords carcinoma were presented. Clinical material consisted of 94 cases with squamous cell carcinoma of vocal cords with stage T1a and T1b treated in Szczecin University Department of Otorhinolaryngology from 1987 to 1996. 51 cases were operated on (26 by chordectomy and 25 by frontolateral laryngectomy). Radiotherapy was applied in 43 patients. The 3 and 5 years' survival rate in the surgery group was 97% and after radiotherapy 88 to 80%. The functional results were also presented. It was concluded that the mode of treatment in early stages of vocal cord carcinoma should be individualized.

[Evaluation of results from radiotherapy and combined treatment of laryngeal cancer (surgery and radiotherapy) considering differentiation of procedures with respect to lymph nodes in the neck]. / Ocena wyników radioterapii oraz skojarzonego leczenia raka krtani (operacja i napromienianie) z uwzglednieniem zróznicowanego postepowania z wezlami chlonnymi szyi.

The aim of the work was to estimate the therapeutic results in patients with laryngeal cancer treated by combined method (surgery and radiotherapy) and radiotherapy alone. In the group of patients treated by combined method the randomised clinical study, concerning regional lymph nodes arrangement, has been performed (Tab. 5). The control group of patients was treated, as before, by radical neck dissection (RND), or modified neck dissection (MND), or regional modified neck dissection (RMND), depending on the advancement of the tumor and lymph nodes involvement, combined with moderate postoperative dose of irradiation (5000-5500 cGy). Adversely, the study group was subjected to more conservative surgery, namely MND, or RMND, or LAC (lymphadenectomy) combined with postoperative, slightly higher, dose of irradiation (5500-6000 cGy) (Tab. 6). Clinical material of 213 patients, treated between 1986-1990 at the Laryngology Department and Radiotherapy Department of Pomeranian Medical Academy, has been analysed. There were 84 patients in the study group, 68 in the control group, and 61 in exclusively irradiated group. The patients treated only surgically as well as those irradiated palliatively were excluded. The best results of treatment have been obtained in the study group (3-year survival 78%, and 5-year survival 69%), worse in the control group (3-year survival 62%, and 5-year survival 51%) and the worst in the exclusively irradiated group (3-year 51%, and 5-year 44%) (Fig. 4). The most frequent cause of failure was local and loco regional relapse. The acute and late radiation morbidity, according to RTOG/EORTC classification, has been also analysed. In the majority of patients only slight and moderate (1 and 2 grade), in some patients 3 grade, and in 2 patients 4 grade morbidity has been observed.

[Serotonin and the immunologic reactivity of the body in taeniasis]. / Untersuchungen über das Serotonin und die immunologische Reaktivität des Organismus bei Taeniose.

Blood serotonin level, 5-HIAA in 24 h urine, serum immunoglobulins-IgG, IgM, IgA, percentage of lymphocytes T and B in rosette test were ascertained in 3 groups of patients with taeniosis, treated with Radeverm (32 patients), Praziquantel (22 patients) and Yomesan (10 patients). Primary hyperserotoninemia and higher level of 5-HIAA in post-treatment values were not uniformly differentiated. The same tendency was observed in post-treatment values of immunoglobulins and lymphocytes T and B as compared with values before treatment.