[Impact of TNF-alpha gene polymorphism, development of atherogenic dyslipidemia and risk of atherosclerosis].

In this 5-year prospective cohort study, 92 clinically healthy subjects (42 men and 50 women) were screened for G-308A polymorphism of the TNF-alpha gene. Fasting serum lipid levels and carotid intima-media thickness (IMT) were measured. Triglyceride levels in the GA+AA group were significantly (more than 3-fold) higher than in GG genotype patients. Patients in the former group had apolipoprotein index above 1 twice more frequently in the latter. The 5-year probability of atherosclerosis in GA+AA male patients was 55.9 +/- 15.4% vs. 9.1 +/- 6.1% in GG men (p < 0.001). The presence of A allele in TNFa gene was associated with a 9 times higher risk of early atherosclerosis estimated using the multivariate stepwise Cox regression model.