Relationship Between Airborne Fungi Presence and the Position of the High Efficiency Particulate Air Filter in the Heating, Ventilation, and Air Conditioning System.

AIM: Establish the influence of the terminal or nonterminal position of High Efficiency Particulate Air (HEPA) filters in the Heating, Ventilation, and Air Conditioning (HVAC) system on the presence of airborne fungi in controlled environment rooms. BACKGROUND: Fungal infections are an important cause of morbidity and mortality in hospitalized patients. METHODS: This study was realized from 2010 to 2017, in rooms with terminal and nonterminal HEPA filters, in eight Spanish hospitals. In rooms with terminal HEPA filters, 2,053 and 2,049 samples were recollected, and in rooms with nonterminal HEPA filters, 430 and 428 samples were recollected in the air discharge outlet (Point 1) and in the center of the room (Point 2), respectively. Temperature, relative humidity, air changes per hour, and differential pressure were recollected. RESULTS: Multivariable analysis showed higher odds ratio (OR) of airborne fungi presence when HEPA filters were in nonterminal position (OR: 6.78; 95% CI [3.77, 12.20]) in Point 1 and (OR: 4.43; 95% CI [2.65, 7.40]) in Point 2. Other parameters influenced airborne fungi presence, such as temperature (OR: 1.23; 95% CI [1.06, 1.41]) in Point 2 differential pressure (OR: 0.86; 95% CI [0.84, 0.90]) and (OR: 0.88; 95% CI [0.86, 0.91]) in Points 1 and 2, respectively. CONCLUSIONS: HEPA filter in terminal position of the HVAC system reduces the presence of airborne fungi. To decrease the presence of airborne fungi, adequate maintenance of the environmental and design parameters is necessary in addition to the terminal position of the HEPA filter.

Effectiveness of a Cognitive-Motor Training Program in Reducing Attentional Cost During Walking in Patients With Multiple Sclerosis.

The purpose of this study was to assess the efficacy of a combined training program (CTP) in reducing the effects of dual tasking on the temporal parameters and kinematics of gait, as compared with single-task gait. A controlled, randomized, intervention study was performed in an intervention group and a control group. The intervention group attended three weekly CTP sessions for 24 weeks. Gait pattern was evaluated prior to the baseline intervention, at 12 weeks, and at 24 weeks (Repost). The sample was composed of 22 subjects diagnosed with multiple sclerosis with an Expanded Disability Status Scale score of 0-5.5. A total of 12 patients were allocated to the intervention group and another 10 to the control group. A three-dimensional photogrammetry scanner was connected to a selective attention system designed to present a dual-task gait condition. Dual tasking had an impact on all spatiotemporal parameters of gait, and the most remarkable effect of dual tasking was on double-support time, which increased by 9% with respect to normal walking. In contrast, dual tasking had a trivial effect on single-support time. The CTP was effective in reducing the effects of dual tasking on stride length and velocity of the center of mass after Repost of training (p < .05). The CTP reduced time in double-support phase, whereas single-support time increased after Repost of intervention. The application of the CTP had no effect on the cost of the double task after 12 weeks of intervention. It is suggested to increase the application time over Repost.

Evaluation of the Results of a Periodic Environmental Biosecurity Assessment Program on Air Quality in Controlled Environment Rooms of Hospitals.

AIM: Determine the utility of the Periodic Environmental Biosecurity Assessment Program (PEBAP) in achieving clean air as measured by the number of colony-forming units (CFU) of fungi and bacteria in the air. BACKGROUND: There is no international consensus on the sampling frequency, the recommended limits for microorganisms in the air nor on the usefulness of routine microbiological air monitoring of hospitals. METHODS: During the PEBAP, data were recollected between 2010 and 2017 in eight hospitals in southeast Spain. Air samples were collected in very high risk rooms (VHRRs) and high risk rooms (HRRs), unoccupied, using active sampling methods. Temperature, relative humidity, air changes per hour (ACH), and differential pressure were measured. When limits of CFU of opportunistic fungi and bacteria established in the PEBAP were exceeded, corrective measures were adopted. RESULTS: We found a reduction (p < .01) of percentage of air samples with fungi growth throughout the years of PEBAP in all rooms. Aspergillus was the most frequent opportunistic fungus. We found a high compliance of the standards of CFU of bacteria in HRR, and the percentage of compliance in VHRR was lower than in HRR in all years. Differences in environmental and design parameters were statistically significant (p < .05) between rooms, except for ACH. CONCLUSIONS: PEBAP resulted in a useful tool to maintain and improve air quality in hospitals. The control of environmental biosecurity requires a multidisciplinary approach from preventive medicine, engineering, and cleaning services. Aspergillus is the most frequent opportunistic fungus in southeast Spain.

Epilepsia en el paciente oncológico: prevención primaria e importancia en la selección del paciente de alto riesgo / Epilepsy in cancer patients: primary prevention and the importance of high-risk patient screening

Introducción: La epilepsia en el paciente oncológico presenta una prevalencia del 13%, especialmente elevada en pacientes con tumores cerebrales, así como una mayor morbimortalidad respecto de la epilepsia no tumoral. Sus mecanismos fisiopatógenos son diferenciadores, e incluyen la distorsión de la arquitectura cortical y la alteración del microambiente molecular tumoral y peritumoral favorecedor de glutamato. A pesar de ello, existe evidencia científica escasa e inconsistente acerca de aspectos fundamentales, como la profilaxis primaria postoperatoria, el perfil farmacológico idóneo o el tiempo de retirada de fármacos anticrisis tras la libertad de éstas. Desarrollo: Características como el bajo grado tumoral, el número/tamaño de las lesiones corticales, la localización (frontal, cortical/subcortical o área elocuente), las crisis tempranas y las alteraciones moleculares, como mutación IDH1/2, son factores favorecedores para la aparición de crisis. Dentro del tratamiento, la cirugía aportará citorreducción y control de crisis por escisión del área epileptógena, con libertad de crisis incapacitantes del 75-90%. Aunque sigue siendo un tema controvertido, el uso postoperatorio de fármacos anticrisis está contraindicado por las principales sociedades científicas por la escasa evidencia y el amplio espectro de efectos secundarios. Sin embargo, se emplean frecuentemente en la práctica clínica diaria. Conclusiones: Todo ello nos obliga a establecer un grupo de pacientes de ‘alto riesgo’ de crisis postoperatorias, que precisará seleccionar el fármaco anticrisis idóneo en prevención primaria, con una vía de administración que facilite un rápido efecto de acción y una farmacocinética que evite el metabolismo hepático y la inducción de CYP450 para conseguir un menor número de interacciones con quimioterápicos, corticoides y radioterapia. A pesar de ello, se describen tasas de farmacorresistencia del 20-40% y recidiva del 25-29%.(AU)

Introduction: Epilepsy in cancer patients has a prevalence of 13%, and is especially high in patients with brain tumours, with a higher morbidity and mortality rate compared to non-tumour-related epilepsy. Its physiopathogenic mechanisms are distinct and include distortion of the cortical architecture and alteration of the glutamate-enhancing tumoural and peritumoural molecular microenvironment. Nevertheless, there is scarce and inconsistent scientific evidence on some fundamental aspects, such as primary post-operative prophylaxis, the ideal pharmacological profile or the withdrawal time of antiseizure drugs after their release. Development: Characteristics such as low tumour grade, number/size of cortical lesions, location (frontal, cortical/subcortical or eloquent area), early seizures and molecular alterations, such as IDH1/2 mutation, are factors that favour the occurrence of seizures. Within the treatment, surgery will provide cytoreduction and seizure control by excision of the epileptogenic area, with 75-90% freedom from disabling seizures. Although still a controversial issue, the post-operative use of antiseizure drugs is contraindicated by the main scientific societies due to the scarce evidence and the wide spectrum of side effects. However, they are frequently used in daily clinical practice. Conclusions: All this forces us to establish a group of patients at ‘high risk’ of postoperative seizures, who will need to select the ideal antiseizure drug for primary prevention, with a route of administration that facilitates a rapid action effect and pharmacokinetics that prevents hepatic metabolism and CYP450 induction to achieve a lower number of interactions with chemotherapy, corticosteroids and radiotherapy. Despite this, drug resistance rates of 20-40% and relapse rates of 25-29% have been reported.(AU)

[Epilepsy in cancer patients: primary prevention and the importance of high-risk patient screening]. / Epilepsia en el paciente oncológico: prevención primaria e importancia en la selección del paciente de alto riesgo.

INTRODUCTION: Epilepsy in cancer patients has a prevalence of 13%, and is especially high in patients with brain tumours, with a higher morbidity and mortality rate compared to non-tumour-related epilepsy. Its physiopathogenic mechanisms are distinct and include distortion of the cortical architecture and alteration of the glutamate-enhancing tumoural and peritumoural molecular microenvironment. Nevertheless, there is scarce and inconsistent scientific evidence on some fundamental aspects, such as primary post-operative prophylaxis, the ideal pharmacological profile or the withdrawal time of antiseizure drugs after their release. DEVELOPMENT: Characteristics such as low tumour grade, number/size of cortical lesions, location (frontal, cortical/subcortical or eloquent area), early seizures and molecular alterations, such as IDH1/2 mutation, are factors that favour the occurrence of seizures. Within the treatment, surgery will provide cytoreduction and seizure control by excision of the epileptogenic area, with 75-90% freedom from disabling seizures. Although still a controversial issue, the post-operative use of antiseizure drugs is contraindicated by the main scientific societies due to the scarce evidence and the wide spectrum of side effects. However, they are frequently used in daily clinical practice. CONCLUSIONS: All this forces us to establish a group of patients at 'high risk' of postoperative seizures, who will need to select the ideal antiseizure drug for primary prevention, with a route of administration that facilitates a rapid action effect and pharmacokinetics that prevents hepatic metabolism and CYP450 induction to achieve a lower number of interactions with chemotherapy, corticosteroids and radiotherapy. Despite this, drug resistance rates of 20-40% and relapse rates of 25-29% have been reported.

TITLE: Epilepsia en el paciente oncológico: prevención primaria e importancia en la selección del paciente de alto riesgo.Introducción. La epilepsia en el paciente oncológico presenta una prevalencia del 13%, especialmente elevada en pacientes con tumores cerebrales, así como una mayor morbimortalidad respecto de la epilepsia no tumoral. Sus mecanismos fisiopatógenos son diferenciadores, e incluyen la distorsión de la arquitectura cortical y la alteración del microambiente molecular tumoral y peritumoral favorecedor de glutamato. A pesar de ello, existe evidencia científica escasa e inconsistente acerca de aspectos fundamentales, como la profilaxis primaria postoperatoria, el perfil farmacológico idóneo o el tiempo de retirada de fármacos anticrisis tras la libertad de éstas. Desarrollo. Características como el bajo grado tumoral, el número/tamaño de las lesiones corticales, la localización (frontal, cortical/subcortical o área elocuente), las crisis tempranas y las alteraciones moleculares, como mutación IDH1/2, son factores favorecedores para la aparición de crisis. Dentro del tratamiento, la cirugía aportará citorreducción y control de crisis por escisión del área epileptógena, con libertad de crisis incapacitantes del 75-90%. Aunque sigue siendo un tema controvertido, el uso postoperatorio de fármacos anticrisis está contraindicado por las principales sociedades científicas por la escasa evidencia y el amplio espectro de efectos secundarios. Sin embargo, se emplean frecuentemente en la práctica clínica diaria. Conclusiones. Todo ello nos obliga a establecer un grupo de pacientes de 'alto riesgo' de crisis postoperatorias, que precisará seleccionar el fármaco anticrisis idóneo en prevención primaria, con una vía de administración que facilite un rápido efecto de acción y una farmacocinética que evite el metabolismo hepático y la inducción de CYP450 para conseguir un menor número de interacciones con quimioterápicos, corticoides y radioterapia. A pesar de ello, se describen tasas de farmacorresistencia del 20-40% y recidiva del 25-29%.

EMMPRIN is an emerging protein capable of regulating cancer hallmarks.

EMMPRIN, also known as Basigin or CD147, is a transmembrane glycoprotein member of the immunoglobulin superfamily. It is expressed basally in cells that regulate physiological processes of the cardiovascular, nervous, and immune systems. However, EMMPRIN is also capable of interacting with different proteins, like VEGFR, SMAD4, Integrin, MCT, CyPA, GLUT1, CAIV, Annexin II, Cav-1, CAML, etc., and regulating signaling pathways that stimulate the cell processes of proliferation, apoptosis, metabolism, adhesion, invasion, migration, metastasis, tumor immune response, and angiogenesis processes, which favors the development of different types of cancer. EMMPRIN is the first protein reported that favors cancer development due to its ability to interact with extracellular, intracellular, and membrane proteins. In conclusion, EMMPRIN regulates several proteins associated with the development of tumor processes. Therefore, blocking the expression of EMMPRIN can be a therapeutic target, and the analysis of its expression can be used as an important biomarker in cancer.

Reliability and magnitude of loaded countermovement jump performance variables: a technical examination of the jump threshold initiation.

Different thresholds have been used to determine the start of the force-time analysis during countermovement jump testing. This study examined the influence of the jump starting threshold on the reliability and magnitude of loaded countermovement jump (CMJ) performance variables. Seventeen males were tested during two sessions using five loading conditions (17-30-45-60-75 kg). The CMJ performance was analysed with a force platform. The initiation of the eccentric phase was defined as the first instant in which the vertical ground reaction force was below system weight by 10 N, 50 N, 1% of system weight (1%SW), 10% of system weight (10%SW) and five standard deviations of system weight minus 30 ms (5SDSW). The 50 N, 10%SW and 5SDSW provided a higher reliability for the mean values of velocity and power as well as for the temporal variables only during the eccentric phase compared to the 10 N and 1%SW threshold (CV ratio>1.15). The magnitude of several variables collected during both phases for the 50 N, 10%SW and 5SDSW thresholds significantly differed with respect to 10 N and 1%SW thresholds (p< 0.05). These results suggest that the jump starting threshold may influence both the reliability and magnitude of loaded CMJ performance variables, especially during the eccentric phase.

Effect of Augmented Feedback on Velocity Performance During Strength-Oriented and Power-Oriented Resistance Training Sessions.

ABSTRACT: Jiménez-Alonso, A, García-Ramos, A, Cepero, M, Miras-Moreno, S, Rojas, FJ, and Pérez-Castilla, A. Effect of augmented feedback on velocity performance during strength-oriented and power-oriented resistance training sessions. J Strength Cond Res 36(6): 1511-1517, 2022-This study examined the effects of providing instantaneous velocity feedback (knowledge of results [KR]) on velocity maintenance across multiple sets during strength-oriented and power-oriented resistance training (RT) sessions. Seventeen men completed 2 strength-oriented RT sessions (4 sets of 5 repetitions at 75% of 1 repetition maximum [1RM] during the back squat [SQ] and bench press [BP] exercises) in 1 week and 2 power-oriented RT sessions (4 sets of 5 repetitions at 30% of 1RM during the countermovement jump [CMJ] and BP throw [BPT] exercises) in another week. Subjects received verbal velocity performance feedback in 1 session (KR) and no KR was provided in another session. Greater velocities during the 4 sets of both strength-oriented (from 4.6 to 11.6%) and power-oriented (from 1.4 to 3.5%) RT sessions were observed. The increments in velocity performance during the KR condition were greater for the CMJ (2.25 ± 0.14 vs. 2.18 ± 0.17 m·s-1; 3.0%) than the BPT (2.33 ± 0.13 vs. 2.29 ± 0.16 m·s-1; 1.7%) and similarly for the SQ (0.59 ± 0.07 vs. 0.55 ± 0.06 m·s-1; 7.5%) and BP (0.47 ± 0.09 vs. 0.44 ± 0.07 m·s-1; 7.8%). The raw differences in the RT velocity for BPT were positively correlated with the raw differences in the RT velocity for SQ (r = 0.524; p = 0.031) and CMJ (r = 0.662; p = 0.004), but the remaining correlations did not reach a statistical significance (r ≤ 0.370; p ≥ 0.123). Although these results support the provision of velocity performance feedback to increase training quality regardless of the type of RT session, the positive effect of KR seems to be more accentuated during strength-oriented compared with power-oriented RT sessions.

Inter-limb differences in unilateral countermovement jump height are not associated with the inter-limb differences in bilateral countermovement jump force production.

This study aimed to explore the relationship between the inter-limb differences in unilateral countermovement (CMJ) height and the inter-limb differences in bilateral CMJ force production, and to elucidate whether the self-reported preferred leg contributes more to force production than the non-preferred leg. Twenty-three senior basketball players performed in a single session eight unilateral CMJs (four with each leg) and four bilateral CMJs. Impulse, peak force, mean force were recorded during the bilateral CMJ, and jump height during the unilateral CMJ. Small correlations were observed between the inter-limb differences in unilateral CMJ height and the inter-limb asymmetries in bilateral CMJ impulse, peak force, and mean force (p ≥ 0.171; r≤-0.142). The self-reported preferred leg revealed a higher performance in 7 out of 23 participants (Kappa = -0.20) for the unilateral CMJ height, 7 out of 23 participants (Kappa = -0.11) for the bilateral CMJ impulse, 6 out of 23 participants (Kappa = -0.36) for the bilateral CMJ peak force, and 8 out of 23 participants (Kappa = -0.34) for the bilateral CMJ mean force. These results highlight that the asymmetries detected during bilateral CMJs cannot be extrapolated to unilateral CMJs, and that the preferred leg generally contributes less to force production than the non-preferred leg during both bilateral and unilateral CMJs.

Between-session reliability of performance and asymmetry variables obtained during unilateral and bilateral countermovement jumps in basketball players.

This study aimed to evaluate the between-session reliability of single-leg performance and asymmetry variables during unilateral and bilateral countermovement jumps (CMJ). Twenty-three basketball players completed two identical sessions which consisted of four unilateral CMJs (two with each leg) and two bilateral CMJs. Mean and peak values of force, velocity and power, impulse, and jump height were obtained separately for each leg using a dual force platform. All performance variables presented an acceptable reliability (CVrange = 4.05-9.98%) with the exceptions of jump height for the unilateral CMJs and mean power, peak velocity, peak power, and impulse for the left leg during the bilateral CMJ (CV≥11.0%). Nine out of 14 variables were obtained with higher reliability during the unilateral CMJ (CVratio≥1.16), and 4 out of 14 during the bilateral CMJ (CVratio≥1.32). Asymmetry variables always showed an unacceptable reliability (ICCrange = 0.15-0.64) and poor/slight levels of agreement in direction (Kapparange = -0.10 to 0.15) for the unilateral CMJ, while an acceptable reliability (ICCrange = 0.74-0.77) and substantial levels of agreement in direction (Kapparange = 0.65 to 0.74) were generally obtained for the bilateral CMJ. These results suggest that single-leg performance can be obtained with higher reliability during the unilateral CMJ, while the bilateral CMJ provides more consistent measures of inter-limb asymmetries.

Unilateral or Bilateral Standing Broad Jumps: Which Jump Type Provides Inter-Limb Asymmetries with a Higher Reliability?

This study aimed to compare the between-session reliability of performance and asymmetry variables between unilateral and bilateral standing broad jumps (SBJ). Twenty-four amateur basketball players (12 males and females) completed two identical sessions which consisted of four unilateral SBJs (two with each leg) and two bilateral SBJs. Mean and peak values of force, velocity and power, and impulse were obtained separately for each leg using a dual force platform. Inter-limb asymmetries were computed using the standard percentage difference for the unilateral SBJ, and the bilateral asymmetry index-1 for the bilateral SBJ. All performance variables generally presented an acceptable absolute reliability for both SBJs (CV range = 3.65-9.81%) with some exceptions for mean force, mean power, and peak power obtained with both legs (CV range = 10.00-15.46%). Three out of 14 variables were obtained with higher reliability during the unilateral SBJ (CVratio ≥ 1.18), and 5 out of 14 during the bilateral SBJ (CVratio ≥ 1.27). Asymmetry variables always showed unacceptable reliability (ICCrange = -0.40 to 0.58), and slight to fair levels of agreement in their direction (Kappa range = -0.12 to 0.40) except for unilateral SBJ peak velocity [Kappa = 0.52] and bilateral SBJ peak power [Kappa = 0.51]) that showed moderate agreement for both SBJs. These results highlight that single-leg performance variables can be generally obtained with acceptable reliability regardless of the SBJ variant, but the reliability of the inter-limb asymmetries in the conditions examined in the present study is unacceptable to track individual changes in performance.

Vertical jump performance is affected by the velocity and depth of the countermovement.

This study aimed to explore the effect of the velocity and depth of the countermovement on vertical jump performance and the shape of the force-time curve. Seventeen university students performed two blocks of 18 countermovement jumps (CMJ) being instructed to jump for maximum height after performing the countermovement at a self-selected (SS-CMJ) or fast (F-CMJ) velocity. Each block consisted of six CMJ from a larger depth, six CMJ from a shorter depth, and six CMJ from a self-preferred depth. Mean and peak values of force, velocity and power, reactive strength index-modified (RSImod), jump height, and the shape of the force-time curve (unimodal or bimodal) were assessed. The F-CMJ provided a higher (mean and peak force, mean velocity, mean power, and RSImod) or comparable (peak power, peak velocity, and jump height) performance than the SS-CMJ. The shorter CMJ provided the highest values of mean and peak force, mean and peak power, and RSImod, while peak velocity and jump height were higher for the larger and self-preferred CMJ. The force-time curve was bimodal during the larger CMJ (100%) and unimodal during the shorter CMJ (65-88%). These results highlight that CMJ performance is influenced by the velocity and depth of the countermovement.

Use of coumarins as complementary medicine with an integrative approach against cervical cancer: background and mechanisms of action.

Cervical cancer is characterized by the cellular transformation caused by Human Papillomavirus (HPV), favoring cell proliferation, migration, invasion, and metastasis. Cervical cancer is conventionally treated with radiation therapy, and chemotherapy focused on the destruction of tumor cells. However, chemoresistance and low selectivity between tumor and non-tumor cells have been reported, causing side effects in patients. Metabolites of natural origin have shown selectivity against tumor cells, suggesting their use for reducing the side effects caused by drugs used in conventional therapy. Among these compounds, several natural coumarins stand out, such as auraptene, scopoletin, osthole, and praeruptorin, of which antiproliferative, anti-migratory, and anti-invasive activity have been reported. Auraptene, scopoletin, osthole, and praeruptorin show a cytotoxic or antiproliferative effect on cervical tumor cells, arresting the cell cycle by inducing the overexpression of negative regulators of the cell cycle, or inducing cell death by increasing the expression of pro-apoptotic proteins and decreasing that of anti-apoptotic proteins. On the other hand, auraptene, scopoletin, and praeruptorin inhibit the capacity for migration, invasion, and metastasis of cervical tumor cells, mainly by inhibiting the expression and activity of matrix metalloproteinase-2 and -9. The PI3K/Akt signal pathway appears to be central to the anti-tumor activity of the coumarins analyzed in this review. In addition, auraptene, osthole, and praeruptorin are useful in sensitizing tumor cells to radiotherapy or chemotherapeutic molecules, such as FOLFOX, cisplatin, or DOX. Coumarins offer an excellent possibility for developing new drugs as complementary medicine with an integrative approach against cervical cancer.

Influence of countermovement depth on the countermovement jump-derived reactive strength index modified.

This study aimed to investigate the effect of countermovement depth on the magnitude of the countermovement jump (CMJ) derived reactive strength index modified (RSImod), and to compare the RSImod between the CMJ performed with a self-preferred knee flexion angle (CMJpref) and the CMJ performed from a pre-determined knee flexion angle (CMJrefer) with the countermovement depth more similar to the CMJpref. Sixteen subjects (11 males and 5 females; age 25.1 ± 6.3 years, body mass 69.7 ± 10.2 kg, body height 172.9 ± 8.1 m) randomly performed in a single session the CMJpref and CMJs from five pre-determined knee flexion angles (60°, 75°, 90°, 105°, and 120°). Our results showed that lower knee flexion angles were generally associated with greater RSImod values with the CMJ performed at 60° showing the greatest RSImod (P ≤ 0.049; effect size [ES] range = 0.19-0.63). The greatest RSImod for the CMJ performed at 60° was caused by the proportionally lower values of the time to take-off (ES range = 0.65-1.91) compared to the decrease observed in jump height (ES range = 0.11-0.25). The RSImod was higher for the CMJpref compared to the CMJrefer (P < 0.001; ES = 0.34) due to a higher jump height (P = 0.021; ES = 0.14) and reduced time to take-off (P < 0.001; ES = 0.85). These results indicate that practitioners should be careful when interpreting an individual's changes in RSImod when the countermovement depth is not similar across the testing sessions. However, since the use of pre-determined knee flexion angles negatively impacts the RSImod, we encourage practitioners to use the CMJpref but only compare the RSImod when CMJs are performed using consistent countermovement depths.

Influence of Coaching Condition on the Magnitude and Reliability of Drop Jump Height in Men and Women.

This study examined the effect of different coaching conditions on the magnitude and reliability of drop jump height in men and women. Nineteen collegiate sport sciences students (10 men) performed two sets of 10 drop jumps under four different coaching conditions: neutral, augmented feedback, external focus of attention, and a combination of augmented feedback and external focus of attention. The augmented feedback condition revealed a significantly higher jump height than the neutral condition (p = .002), while no significant differences were observed for the remaining conditions (p ≥ .38). The external focus of attention condition was more reliable than the neutral and augmented feedback conditions (coefficient of variationratio ≥ 1.15), while no differences were observed between the remaining conditions. These results suggest that both the magnitude and reliability of the drop jump height performance are influenced by the coaching condition.

Velocity Performance Feedback During Ballistic Training: Which Is the Optimal Frequency of Feedback Administration?

This study explored the impact of different frequencies of knowledge of results (KR) on velocity performance during ballistic training. Fifteen males completed four identical sessions (three sets of six repetitions at 30% one-repetition maximum during the countermovement jump and bench press throw) with the only difference of the KR condition provided: no feedback, velocity feedback after the first half of repetitions of each set (HalfKR), velocity feedback immediately after each repetition (ImKR), and feedback of the average velocity of each set (AvgKR). When compared with the control condition, the ImKR reported the highest velocity performance (1.9-5.3%), followed by the HalfKR (1.3-3.6%) and AvgKR (0.7-4.3%). These results support the verbal provision of velocity performance feedback after every repetition to induce acute improvements in velocity performance.

Manejo perioperatorio de feocromocitoma y paraganglioma / Perioperative management of paragangliomas and pheochromocytomas

Los feocromocitomas y paragangliomas son tumores neuroendocrinos raros, caracterizados por una alta tasa de morbilidad debida a un exceso de niveles de catecolaminas. Este exceso de catecolaminas es independiente de los estresores fisiológicos. Para el diagnóstico de un feocromocitoma-paraganglioma son fundamentales las pruebas bioquímicas. Las más utilizadas son las metanefrinas fraccionadas urinarias o metanefrinas libres plasmáticas. Seguido del diagnóstico bioquímico, debe realizarse un estudio imagenológico. La evaluación del paciente con diagnóstico de feocromocitoma-paraganglioma debe realizarse teniendo presente sus principales causas de morbimortalidad perioperatoria. Las dos grandes intervenciones que han disminuido la mortalidad perioperatoria son la introducción del α bloqueo y la restauración de la volemia. El otro gran avance ha sido la introducción de la cirugía laparoscópica como el estándar de oro para el abordaje quirúrgico. En relación con el manejo intraoperatorio, no se ha identificado que alguna técnica anestésica sea superior a otra. Sí se ha logrado establecer criterios de inestabilidad hemodinámica que se correlacionan con mayor morbilidad, por lo que los principales objetivos intraoperatorios son mantener estabilidad hemodinámica. El avance en el manejo preoperatorio e intraoperatorio con la consecuente disminución en la mortalidad relacionada a esta patología ha llevado el foco al manejo postoperatorio tanto agudo como a largo plazo. También se debe considerar el riesgo de recurrencia tumoral, por lo que estos pacientes deben tener un control anual de por vida.

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors, characterized by a high morbidity rate due to catecholamine excess. These high levels are independent of physiologic stressors. For the diagnosis, a biochemical workup is paramount. The most widely used are plasma-free metanephrines and urinary fractionated metanephrines. Imaging studies should be initiated once the biochemical diagnosis is established. Evaluation of the patient with pheochromocytomas and paragangliomas must be done taking into account the leading causes of perioperative morbidity and mortality. The two primary interventions that have reduced perioperative mortality are alpha-adrenergic blockade and intravascular volume normalization. Another significant advance has been the establishment of laparoscopic surgery as the gold standard for the surgical approach. No anesthetic technique has been found to be superior to another. Intraoperative hemodynamic instability has been correlated with poorer outcomes; thus one of the main intraoperative goals is maintaining hemodynamic stability. Lower morbidity and almost zero mortality rates due to preoperative and intraoperative management improvements have led to a focus on the immediate and long-term postoperative care. Anual lifelong follow-up is recommended to detect recurrent disease.

Assessment of unloaded and loaded squat jump performance with a force platform: Which jump starting threshold provides more reliable outcomes?

This study aimed to explore the influence of different onset thresholds on the between-session reliability and magnitude of squat jump (SJ) performance. Twenty men were tested on two sessions separated by 48 h against external loads of 0.5, 30 and 60 kg. The initiation of the jump was defined as the first instant in which the vertical ground reaction force exceeded system weight by 10 N (10 N), 50 N (50 N), 1% of system weight (1%SW), 10% of system weight (10%SW) and five standard deviation of system weight minus 30 ms (5SDSW). The following variables were calculated from the force-time signal collected on a force platform: mean, peak and time to peak values of force, power and velocity, average rate of force development, peak rate of force development, rate of force development index, impulse, jump height, and push-off time. The 50 N, 10%SW and 5SDSW thresholds generally revealed a higher reliability than the 10 N and 1%SW thresholds (97 and 21 out of 252 comparisons for the coefficient of variation and intraclass correlation coefficient, respectively). The magnitude of most of the variables calculated using the 50 N and 10%SW thresholds significantly differed with respect to the 10 N, 1%SW and 5SDSW thresholds (P < 0.05). These results suggest that both the reliability and magnitude of SJ performance variables are influenced by the jump starting threshold. The 50 N, 10%SW and 5SDSW thresholds maximise the reliability of SJ performance variables, while the 5SDSW should be recommended since it considers more force signal than the 50 N and 10%SW thresholds.

Obstrucción intestinal por hernia obturatriz: serie de casos / Intestinal obstruction caused by obturator hernia: case series

OBJETIVO: Se presentan 3 casos de obstrucción intestinal por hernia obturatriz atascada, su manejo y una breve revisión de la literatura. MATERIALES Y MÉTODOSles y Métodos: Discusión del cuadro clínico, imágenes y manejo. Todos los casos fueron operados dentro del mismo día del diagnóstico y se confirmó la presencia de hernia obturatriz. El manejo de la hernia y su contenido fue ajustado a la situación de cada paciente. RESULTADOS: Los tres casos de hernia obturatriz aquí discutidos tienen la presentación clásica del cuadro, cuando se los revisa en forma retrospectiva y con imagenología compatible. Los tres pacientes evolucionaron en forma satisfactoria con alta precoz y control posoperatorio sin incidentes. Discusión: Nuestros 3 casos se condicen tanto en hallazgos clínicos, imagenológicos y en manejo con lo descrito en la literatura internacional. CONCLUSIÓN: La hernia del agujero obturatriz siendo infrecuente, se presenta en un tipo particular de pacientes y con sintomatología clásica. La tomografía axial computada es de gran ayuda y suele hacer el diagnóstico preciso en el preoperatorio. Es importante recordar este diagnóstico diferencial al momento de estudiar pacientes con obstrucción intestinal.

OBJECTIVE: 3 cases of intestinal obstruction that resulted in diagnosis of obturator hernia, their management and a brief international literature review are presented. MATERIAL AND METHODS: Discussion of the presentation, images, and management. In all cases surgery was performed the same day from the diagnosis of intestinal obstruction and confirmation of obturator hernia. The management of the hernia and it's content was adjusted to each patient's situation. RESULTS: Our 3 patients, when reviewed retrospectively, had the classic presentations and images of obturator hernia. All of them had a favourable evolution with an early discharge and no complications on follow up. DISCUSSION: Our 3 cases had clinical presentations and imaging studies that correlated well with international literature. CONCLUSION: Obturator hernia is an infrequent pathology, but appears in a particular type of patient and with classic presentation. Axial computed tomography is an important tool and usually makes the diagnosis previously to surgical exploration. It is important to consider this diagnosis when being faced with patients with intestinal obstruction.

Components of attack response inhibition in fencing: Components of attack response inhibition in fencing.

Applying the Go/No-Go paradigm to fencing, we investigated the relationship between the moment at which the No-Go signal appeared after a movement had been initiated and the time required by fencers to suppress the motor execution of a step-lunge. Secondarily, we determined a time threshold from which movement inhibition results in an error. The No-Go stimulus was represented by a real attack movement. 18 elite fencers and a fencing master were included in the study. Four force plates measured the horizontal components of the fencer's and master's reaction forces, which were used to calculate the time components of the attack and the response inhibition process. Also, the velocity and displacement of the master's and fencer's respective centres of mass were estimated using inverse dynamics. In all cases, cognitive inhibition processes were completed after the onset of movement. Movement time was calculated using four time components (muscle activation, muscle deactivation, transition and braking time). The results obtained revealed that cognitive processes were not significantly affected by the timing of the appearance of the No-Go signal. In contrast, movement time and its time components tended to decrease when the time delay between the No-Go stimulus and the onset of the fencer's movement increased. In conclusion, any attempt to withhold an attack movement when it has already started leads to an error that increases the risk of being hit by the opponent, especially when attack is inhibited within 150 ms after the movement has started.