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1.
BMC Psychiatry ; 11: 26, 2011 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-21320302

RESUMO

BACKGROUND: Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. METHODS: Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls. RESULTS: A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients. CONCLUSIONS: Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.


Assuntos
Antioxidantes/fisiologia , Glutationa/deficiência , Glutationa/metabolismo , Transtornos Psicóticos/metabolismo , Transtornos Psicóticos/fisiopatologia , Esquizofrenia/metabolismo , Esquizofrenia/fisiopatologia , Adolescente , Idade de Início , Antioxidantes/metabolismo , Estudos de Casos e Controles , Catalase/sangue , Catalase/metabolismo , Criança , Manual Diagnóstico e Estatístico de Transtornos Mentais , Eritrócitos/enzimologia , Eritrócitos/metabolismo , Feminino , Glutationa/sangue , Glutationa Peroxidase/sangue , Glutationa Peroxidase/metabolismo , Humanos , Peroxidação de Lipídeos/fisiologia , Masculino , Estresse Oxidativo/fisiologia , Transtornos Psicóticos/sangue , Espécies Reativas de Oxigênio/metabolismo , Esquizofrenia/sangue , Superóxido Dismutase/sangue , Superóxido Dismutase/metabolismo
2.
Neurosci Lett ; 363(1): 25-8, 2004 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-15157989

RESUMO

The opioid system has been implicated in mood disorders as well as in the mechanism of action of antidepressants. Since the opioid component in venlafaxine (VLX) is still a matter of discussion, we investigated the role of opioid receptors in the antidepressant-like effect of VLX in the forced swimming test in mice. The non-selective opiate antagonist naloxone at high dose (2 mg/kg, s.c.) antagonized the effect of VLX. In contrast, beta-funaltrexamine (40 mg/kg, s.c.), which preferentially blocks mu(1)/mu(2) opioid receptors, naloxonazine (35 mg/kg, s.c.), a selective mu(1) opioid antagonist, naltrindole (10 mg/kg, s.c.), a selective delta opioid antagonist, and Nor-binaltorphimine (10 mg/kg, s.c.), which selectively blocks kappa-opioid receptors, were all ineffective. Thus, although apparently mediated by the opioid system, the behavioural effect of VLX does not involve specific opioid receptors.


Assuntos
Antidepressivos/farmacologia , Comportamento Animal/efeitos dos fármacos , Cicloexanóis/farmacologia , Antagonistas de Entorpecentes/farmacologia , Natação/fisiologia , Análise de Variância , Animais , Relação Dose-Resposta a Droga , Interações Medicamentosas , Masculino , Camundongos , Cloridrato de Venlafaxina
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