RESUMO
The psychological effects of isolation have already been described in the literature (polar expeditions, submarines, prison). Nevertheless, the scale of confinement implemented during the COVID-19 pandemic is unprecedented. In addition to reviewing the published studies, we need to anticipate the psychological problems that could arise during or at a distance from confinement. We have gone beyond the COVID-19 literature in order to examine the implications of the known consequences of confinement, like boredom, social isolation, stress, or sleep deprivation. Anxiety, post-traumatic stress disorder, depression, suicidal or addictive behaviours, domestic violence are described effects of confinement, but the mechanisms of emergence of these disorders and their interrelationships remain to be studied. For example, what are the mechanisms of emergence of post-traumatic stress disorders in the context of confinement? We also remind the reader of points of vigilance to be kept in mind with regard to eating disorders and hallucinations. Hallucinations are curiously ignored in the literature on confinement, whereas a vast literature links social isolation and hallucinations. Due to the broad psychopathological consequences, we have to look for these various symptoms to manage them. We quickly summarize the diagnostic and therapeutic approaches already in place, such as telemedicine, which is undergoing rapid development during the COVID-19 crisis.
Assuntos
Betacoronavirus , Infecções por Coronavirus , Pandemias , Isolamento de Pacientes/psicologia , Pneumonia Viral , Isolamento Social/psicologia , Adulto , Transtornos de Ansiedade/etiologia , Transtornos de Ansiedade/psicologia , Comportamento Aditivo/etiologia , Comportamento Aditivo/psicologia , Tédio , COVID-19 , Criança , Maus-Tratos Infantis , Infecções por Coronavirus/psicologia , Atenção à Saúde , Depressão/etiologia , Depressão/psicologia , Violência Doméstica/psicologia , Transtornos da Alimentação e da Ingestão de Alimentos/etiologia , Transtornos da Alimentação e da Ingestão de Alimentos/psicologia , França , Alucinações/etiologia , Alucinações/psicologia , Acessibilidade aos Serviços de Saúde , Humanos , Serviços de Saúde Mental/organização & administração , Pneumonia Viral/psicologia , SARS-CoV-2 , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/psicologia , Transtornos de Estresse Pós-Traumáticos/etiologia , Transtornos de Estresse Pós-Traumáticos/psicologia , Suicídio/psicologia , TelemedicinaRESUMO
Phenylcyclohexenes (PCHs) [e.g., trans-4-nitro-5-(2,3,4-trimethoxyphenyl)cyclohexene, 2d] were found to bind weakly to the colchicine site of bovine tubulin, but are the first mimics of colchicine found to have high activity towards plant cells. Structure-activity relationships for PCHs and biphenyl AC-ring analogues of colchicine (e.g., 2,3,4,4'-tetramethoxy-2'-methyl-1,1'-biphenyl, 3e) are discussed.