RESUMO
CASO CLÍNICO: Paciente mujer de 73 años diagnosticada de coloboma de cristalino tras ser derivada a consulta para cirugía de catarata. DISCUSIÓN: La incidencia de coloboma en España por cada 10.000 nacimientos es de 0,5, en Francia de 1,4, en Estados Unidos de 2,6 y en China de 7,5. El diagnóstico es clínico mediante visualización directa. El pronóstico visual depende de la extensión y gravedad del defecto. El tratamiento de la catarata se realizó mediante la técnica convencional de facoemulsificación más lente intraocular de cápsula posterior (FACO + LIO CP) con ayuda de anillo de tensión capsular
CASE REPORT: We present a seventy-three year-old female diagnosed with lens coloboma when she was going to be operated on for cataracts. DISCUSSION: The incidence of congenital coloboma of the eye is estimated to be 0.5 per 10000 newborns in Spain, 1.4 in France, 2.6 in United States, and 7.5 in China. The diagnosis is clinical by observing the defect. The visual prognosis depends on the extent and severity of the coloboma. The treatment of the cataract was by phacoemulsification with an intraocular lens using a capsular tension ring
Assuntos
Feminino , Humanos , Extração de Catarata/legislação & jurisprudência , Extração de Catarata/métodos , Gonioscopia/instrumentação , Gonioscopia/métodos , Extração de Catarata/classificação , Extração de Catarata/normas , Gonioscopia/normas , GonioscopiaRESUMO
CASE REPORT: We present a seventy-three year-old female diagnosed with lens coloboma when she was going to be operated on for cataracts. DISCUSSION: The incidence of congenital coloboma of the eye is estimated to be 0.5 per 10000 newborns in Spain, 1.4 in France, 2.6 in United States, and 7.5 in China. The diagnosis is clinical by observing the defect. The visual prognosis depends on the extent and severity of the coloboma. The treatment of the cataract was by phacoemulsification with an intraocular lens using a capsular tension ring.
Assuntos
Coloboma/cirurgia , Cristalino/anormalidades , Idoso , Animais , Astigmatismo/etiologia , Coloboma/complicações , Coloboma/diagnóstico por imagem , Feminino , Humanos , Implante de Lente Intraocular , Cristalino/diagnóstico por imagem , Facoemulsificação , Prognóstico , Microscopia com Lâmpada de Fenda , Descolamento do Vítreo/complicaçõesRESUMO
The cell sensitivity of recombinant human alpha interferons (rIFN-alpha) of greater than 95% purity (A,D and the hybrid A/D) and crude nature (B and F) was studied in human (WISH, HeLa, AG1732), bovine (MDBK, BT), monkey (Vero), mouse (L), rabbit (RK-13), and hamster (BHK-21) cells. Based on an activity of 100% in WISH cells, the other cells responded to rIFN-alpha A as follows: AG1732 (90%), HeLa (94%), and MDBK and BT cells (170-190%). Rabbit, mouse, and hamster cells had a relative sensitivity of less than 1%. rIFN-alpha B and F were essentially equivalent to rIFN-alpha A in terms of cell sensitivity, but MDBK and BT cells were about 20 times more sensitive to rIFN-alpha D than were WISH cells and rIFN-alpha D was 1/5 to 1/10 as active on L cells as on WISH cells. The activity of the hybrid IFN A/D on bovine, mouse, and human cells was similar. The inhibitory dose50 (U/ml) of rIFN-alpha A, B, D, and F against virus infections in WISH cells were: vesicular stomatitis virus (1-4), rhinovirus types 1 and 42 (2-18), and herpes simplex virus (HSV) type 2 (45-70). Type 1 HSV, Semliki Forest (SFV) and encephalomyocarditis (EMC) viruses were tested against only rIFN-alpha A and D where SFV and EMC were the most sensitive to both IFNs (ID50-SFV, 0.2 U/ml, EMC, 1.2 U/ml) while 13 U/ml of rIFN-alpha A and D inhibited Type 1 HSV. The various rIFN-alpha s did not exhibit different antiviral spectra in vitro. When tested in mice rIFN-alpha A did not protect against infections with SFV, EMC, HSV, or influenza viruses. rIFN-alpha D and A/D protected mice infected with EMC, SFV, or HSV.
