No association between ACE I/D polymorphism and cardiovascular hemodynamics during exercise in young women.

The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consumption (VO2), cardiac output (Q), stroke volume (SV), heart rate (HR), blood pressure (BP), total peripheral resistance (TPR), and arteriovenous oxygen difference ([a-v]O2 diff) during submaximal and maximal exercise in young sedentary and endurance-trained women. Seventy-seven 18-35-yr-old women underwent a maximal exercise test and a number of cardiac output tests on a treadmill using the acetylene rebreathing technique. ACE genotype was not significantly associated with VO2max (II 41.4+/-1.2, ID 39.8+/-0.9, DD 39.8+/-1.1 ml/kg/min, p=ns) or maximal HR (II 191+/-2, ID 191+/-1, DD 193+/-2 bpm, p=ns). In addition, systolic and diastolic BP, (a-v)O2 diff, TPR, SV, and Q during maximal exercise were not significantly associated with ACE genotype. During submaximal exercise, SBP, Q, SV, HR, TPR, and (a-v)O2 diff were not significantly associated with ACE genotype. However, the association between diastolic BP during submaximal exercise and ACE genotype approached significance (p=0.08). In addition, there were no statistically significant interactions between ACE genotype and habitual physical activity (PA) levels for any of the submaximal or the maximal exercise hemodynamic variables. We conclude that the ACE I/D polymorphism was not associated, independently or interacting with habitual PA levels, submaximal, or maximal cardiovascular hemodynamics in young women.

Acute resistive exercise does not affect ambulatory blood pressure in young men and women.

PURPOSE: Resistive exercise elicits a pressor response that results in a dramatic increase in blood pressure (BP) during the exercise. However, it is not known if the BP elevation persists after resistive exercise. METHODS: This study examined the effects of an acute resistive exercise session on 24-h ambulatory BP in sedentary (5 men, 6 women), resistance-trained (6 men, 6 women), and endurance-trained (4 men, 6 women) young subjects (age 22 +/- 3.2 yr) with normal BP. Two 24-h ambulatory BP recordings were made on each subject, one after two sets of resistive exercise on 12 weight machines and one after 48 h without prior exercise. RESULTS: Systolic, diastolic, and mean arterial BP and heart rate (HR) were not different in the hours after and for up to 24 h after the single resistive exercise session compared with the control day. There also was no difference in the ambulatory BP or HR response after the single session of resistive exercise based on the training status of the subjects. CONCLUSION: Thus, the elevated BP that occurs during resistive exercise does not persist in the 24 h after acute resistive exercise in sedentary, resistance-trained, or endurance-trained, young, normotensive men and women.