RESUMO
Results of treatment of 238 patients, suffering an acute gastrointestinal hemorrhage, occurring on background of application of medicinal preparations, were adduced. The incidence rate for an acute medicinal ulcers of foregut was analyzed, as well as possibilities for their treatment.
Assuntos
Hemostase Endoscópica/métodos , Úlcera Péptica Hemorrágica/induzido quimicamente , Úlcera Péptica Hemorrágica/terapia , Úlcera Péptica/induzido quimicamente , Úlcera Péptica/terapia , Preparações Farmacêuticas , Doença Aguda , Adulto , Idoso , Idoso de 80 Anos ou mais , Endoscopia do Sistema Digestório , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Úlcera Péptica/tratamento farmacológico , Úlcera Péptica Hemorrágica/tratamento farmacológico , Troca Plasmática , Inibidores da Bomba de Prótons/administração & dosagem , Inibidores da Bomba de Prótons/uso terapêutico , Resultado do TratamentoRESUMO
The aim of this study was to investigate the dynamics of the incidence of malignant tumors of the maxillofacial region in the Ivano-Frankivsk region, based on a retrospective analysis of the record charts of patients from 2000 to 2010. The study investigated the dynamics of indicators of malignant tumors of the maxillofacial region according to the Ivano-Frankivsk Clinical Oncology Center on the basis of a retrospective analysis of 417 patients with registration cards. The characteristic of the prevalence of malignant tumors of the maxillofacial area of the region by gender and localization of the pathological process.
Assuntos
Neoplasias Maxilares , Caracteres Sexuais , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Neoplasias Maxilares/epidemiologia , Neoplasias Maxilares/patologia , Pessoa de Meia-Idade , Estudos Retrospectivos , UcrâniaRESUMO
Here presented the data on the frequencies of chromosome aberrations in lymphocytes of peripheral blood of 97 volunteers depending on genotypes by genes of xenobiotics detoxication before and after gamma-irradiation with dose of 1 Gy in vitro. The frequencies of aberrations were estimated by analyzing not less than 500-1000 metaphases per person. The data of cytogenetic analysis were compared with the results of PCR-genotyping of loci GSTM1, GSTT1, GSTP1, CYP1A1, CYP2D6, NAT2, and MTHFR. The significant differences by the frequencies of aberrations between "single-locus" genotypes were not found except for GSTM1 locus, for which the enhanced frequency of spontaneous aberrations of chromosome type in "positive" genotypes compared to "zero" ones, i.e., homozygotes by deletion (p = 0.04) was observed. The minimum frequency of spontaneous aberrations of chromosome type was recorded for carriers of double homozygotes by deletion of GSTM1-GSTT1: 0.0006 +/- 0.0003 against 0.0027 +/- 0.0003 for the rest of genotypes (p = 0.016 by the Mann-Witney test). The frequency of gamma-induced chromosome aberrations was correlated with the total amount of minor alleles in loci GSTP1, NAT2, and MTHFR (r = 0.25 at p = 0.0065).
