STATE OF MICROCIRCULATION AND FREE-RADICAL PROCESSES OF PERIODONTAL TISSUES IN SMOKING DEPENDENT PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ASSOCIATED WITH CHRONIC HYPERACID GASTRITIS.

OBJECTIVE: The aim: The aim of the work was to determine the state of microcirculation and free radical processes of periodontal tissues in smoking dependent patients with chronic generalized periodontitis associated with chronic hyperacid gastritis. PATIENTS AND METHODS: Materials and methods: We examined 90 patients (men and women) aged 25 to 44 years, who were divided into 3 groups: the first group - 48 smoking patients with chronic generalized periodontitis and chronic hyperacid gastritis associated with Helicobacter pylori; the second group - 22 patients with chronic generalized periodontitis and chronic hyperacid gastritis associated with Helicobacter pylori, without the bad habit; the third group - control, consisted of 20 healthy individuals. The smoking patients were randomly divided into two subgroups: patients of the first subgroup (G1.1) received the basic therapy of chronic generalized periodontitis and the proposed treatment and prevention complex; the patients in the second subgroup (G1.2) received basic therapy for chronic generalized periodontitis and ultraphonophoresis with placebo. RESULTS: Results: The use of treatment and prevention complex in smoking dependent patients and patients without the bad habit with chronic generalized periodontitis and chronic hyperacid gastritis associated with Helicobacter pylori demonstrated a positive dynamics of the functional characteristics of microcirculation and the balance in the lipid peroxidation - antioxidant system. CONCLUSION: Conclusions: So, the use of the proposed treatment and prevention complex had a positive effect on the state of microcirculation and free radical processes of periodontal tissues both at the near and long-term follow up, even under conditions of chronic hyperacid gastritis and the risk factor - smoking.

EVALUATION OF EFFECTIVENESS OF TREATMENT-AND-PROPHYLACTIC COMPLEX IN TOBACCO-ADDICTED PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ON THE BACKGROUND OF CHRONIC HYPERACID GASTRITIS.

OBJECTIVE: The aim: To evaluate the clinical efficacy of treatment-and-prophylactic complex in patients addicted to tobacco with chronic generalized periodontitis with chronic hyperacid gastritis. PATIENTS AND METHODS: Materials and methods: 68 patients (men and women) aged 25-44 years were examined. They were distributed into two groups: the main group - 48 patients addicted to tobacco with chronic generalized 1 degree periodontitis and chronic hyperacid gastritis, associated with Helicobacter pylori, the control group - 20 healthy individuals without bad habits. Patients of the main group were distributed at random into 2 subgroups (1.1, 1.2) depending on the chosen therapy. The patients of the subgroup 1.1 received the basic therapy and the developed treatment and prophylactic complex, the subgroup 1.2 received the basic therapy and the ultraphonophoresis procedures with placebo. Assessment of the effectiveness of therapy was carried out by determining hygienic index OHI-S and periodontal indices (PI, PMA index and Muhlemann bleeding index (MBI)). RESULTS: Results: The usage of the treatment-and-prophylactic complex resulted in improvement of the hygienic index OHI-S and periodontal indices (PI, PMA index and MBI) at the immediate and late observation period. CONCLUSION: Conclusions: Results of the study confirmed the effectiveness of the proposed treatment-and-prophylactic complex in therapy of chronic generalized 1 degree periodontitis in patients addicted to tobacco smoking with chronic hyperacid gastritis.

Efficiency of local therapy with the use of a new preparation for oral care at periodontitis in the course of hyperpeptic gastritis after tobacco smoke intoxication.

OBJECTIVE: Introduction: Periodontal diseases, arising against a background of stomach pathology at tobacco addiction remain an acute problem of modern dentistry. The aim of the work is an experimental study of efficiency of application of the new preparation for oral care during treatment of periodontitis simulated against a background of hyperpeptic gastritis under conditions of intoxication by tobacco smoke. PATIENTS AND METHODS: Materials and methods: At the first stage all experimental animals were divided into 4 groups: І - intact, II - with simulated periodontitis, III - with simulated periodontitis against a background of simulated hyperpeptic gastritis, IV - with simulated periodontitis against a background of hyperpeptic gastritis under conditions of tobacco smoking. Biochemical researches at periodontitis in rats were conducted for determination of influencing stomach pathology and tobacco smoke. On the II stage efficiency of local therapy was studied with the use of the new preparation for oral care and a comparator agent. RESULTS: Results: At experimental periodontitis against a background of hyperpeptic gastritis under conditions of smoking the considerable changes in periodontal tissues typical for the inflammatory process develop. The local therapy at rats with the use of the new preparation resulted in accelerating removing harmful influence of damaging factors and restoring the state of periodontal tissues, than in case of application of the comparator agent. CONCLUSION: Conclusions: The efficiency of the new preparation consists in normalizing influence on processes of lipid peroxidation, inflammation and activation of the protective systems of oral cavity during periodontitis which arises up against a background of hyperpeptic gastritis.