RESUMO
Chronic experiments were made to study cumulation and metabolism of 114C-octadecane in rat organs and tissues. A progressive utilization of the indicator by the animals' body was disclosed, the highest content of the label being found in the adipose tissue and adrenals. Octadecane does not excrete with the urine. The latter's activity is determined by the metabolites of the hydrocarbon under consideration. On the basis of the differences between the total radioactivity of the test organs and tissues and the content of labeled octadecane, as well as from the activity of exhaled CO2, it is concluded that n-alkane metabolizes in the rat body to the final products of metabolism. However, in consequence of retardation and low rate of biotransformation one can see octadecane cumulation in the rat body. Both octadecane and its metabolites are characterized by high affinity for adipose tissue.
Assuntos
Alcanos/metabolismo , Administração Oral , Animais , Biotransformação , Radioisótopos de Carbono , Masculino , Ratos , Fatores de Tempo , Distribuição TecidualRESUMO
A theoretical and experimental study of metabolic processes is presented. Dynamics of water exchange in the living organism under normal and pathological conditions is described. The investigation performed states that the coefficients of analytical equations and constant removal of tritium water from the organism depends on the form and degree of pathology, i.e. pn the change of the constants of water passage from one water reservoir into another.
Assuntos
Água Corporal/metabolismo , Cinética , Matemática , Modelos BiológicosRESUMO
A combined effect of hypokinesia and body position at different angles to the gravity vector on the water content and rate of its metabolism was studied. It was shown that bed rest reduced total water losses and the rate of its metabolism. It was body position as related to the gravity vector rather than bed rest that influenced the total water content in the body.
