1.
Anticancer Drug Des
; 8(4): 257-68, 1993 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8240655
RESUMO
A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was selected for in vivo studies and presents an interesting activity in MX-1 and OVCAR models. (22) also acts as antitopoisomerase II.