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Parasite Immunol ; 44(1-2): e12897, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34762755

RESUMO

Signalling by IFN-y and CD40 is known to trigger anti-microbial activity in macrophages infected with Toxoplasma gondii, but their effects on infected neurons are less well known. Here, we compared how stimulation with IFN-y and an agonistic anti-CD40 mAb impacts infection and cyst formation in the mouse neuroblastoma cell line Neuro-2a relative to bone marrow-derived macrophages. Both IFN-y and CD40 mAb decreased cyst emergence in Neuro-2a cells. In macrophages, these stimuli decreased infection, but had no impact on infection in the neuroblastoma cell line. Resistance to killing in Neuro-2a cells may explain why neurons preferentially harbour parasites during chronic infection in the brain.


Assuntos
Antígenos CD40 , Interferon gama , Toxoplasma , Animais , Antígenos CD40/metabolismo , Linhagem Celular Tumoral , Interferon gama/metabolismo , Camundongos , Neuroblastoma , Toxoplasma/patogenicidade
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