The association between sleep quality and the degree of coronary atherosclerotic stenosis / 中国医师杂志

Objective@#To explore the correlation between sleep and the severity of coronary artery stenosis, and to further guide the prevention and control of coronary heart disease.@*Methods@#A total of 302 patients, including 183 males and 119 females, were enrolled in the department of cardiology of Changhai hospital from February to June 2019. The patients were divided into three groups according to the degree of stenosis (atherosclerotic group, atherosclerotic group with degree of stenosis <50%, atherosclerotic group with degree of stenosis 50%-70%, and atherosclerotic group with degree of stenosis >70%). General information, comorbidities and Pittsburgh sleep quality index (PSQI) of patients in each group were analyzed to compare the differences and analyze the risk factors of aggravated coronary artery stenosis.@*Results@#There were statistically significant differences in age, gender and diabetes among all groups (P<0.05). There was no statistically significant difference in the incidence of hypertension and hyperlipidemia in each group (P>0.05). Spearman correlation analysis showed that PSQI score was positively correlated with the degree of atherosclerosis (P<0.01). In the multivariate regression model, poorer sleep quality (OR=1.75, 95% CI: 1.14-2.69, P<0.05), shorter sleep time (OR=1.64, 95% CI: 1.05-2.55, P<0.05) and more diurnal dysfunction (OR=1.45, 95% CI: 1.11-1.88, P<0.01) were correlated with increased coronary artery stenosis. Higher PSQI total score (OR=1.13, 95% CI: 1.06-1.20, P<0.01) and lower PSQI evaluation grade (very bad vs very good: 13.85, 95% CI: 1.56-122.82, P<0.05) were also related to the increase of coronary artery stenosis.@*Conclusions@#Poorer sleep quality, shorter sleep time and more diurnal dysfunction were independent risk factors for the aggravation of coronary artery stenosis. Higher Pittsburgh sleep quality index was significantly associated with the severity of coronary artery stenosis.

The association between sleep quality and the degree of coronary atherosclerotic stenosis / 中国医师杂志

Objective To explore the correlation between sleep and the severity of coronary artery stenosis,and to further guide the prevention and control of coronary heart disease.Methods A total of 302 patients,including 183 males and 119 females,were enrolled in the department of cardiology of Changhai hospital from February to June 2019.The patients were divided into three groups according to the degree of stenosis (atherosclerotic group,atherosclerotic group with degree of stenosis ＜ 50％,atherosclerotic group with degree of stenosis 50％-70％,and atherosclerotic group with degree of stenosis ＞ 70％).General information,comorbidities and Pittsburgh sleep quality index (PSQI) of patients in each group were analyzed to compare the differences and analyze the risk factors of aggravated coronary artery stenosis.Results There were statistically significant differences in age,gender and diabetes among all groups (P ＜ 0.05).There was no statistically significant difference in the incidence of hypertension and hyperlipidemia in each group (P ＞ 0.05).Spearman correlation analysis showed that PSQI score was positively correlated with the degree of atherosclerosis (P ＜ 0.01).In the multivariate regression model,poorer sleep quality (OR =1.75,95％ CI:1.14-2.69,P ＜0.05),shorter sleep time (OR =1.64,95％ CI:1.05-2.55,P ＜0.05) and more diurnal dysfunction (OR =1.45,95％ CI:1.11-1.88,P ＜0.01) were correlated with increased coronary artery stenosis.Higher PSQI total score (OR =1.13,95％ CI:1.06-1.20,P ＜ 0.01)and lower PSQI evaluation grade (very bad vs very good:13.85,95％ CI:1.56-122.82,P＜0.05) were also related to the increase of coronary artery stenosis.Conclusions Poorer sleep quality,shorter sleep time and more diurnal dysfunction were independent risk factors for the aggravation of coronary artery stenosis.Higher Pittsburgh sleep quality index was significantly associated with the severity of coronary artery ste-nosis.

Efficacy and safety of domestic olmesartan in treatment of mild to moderate essential hypertension / 上海交通大学学报（医学版）

Objective To evaluate the efficacy and safety of domestic olmesartan in treatment of mild to moderate essential hypertension in comparison with losartan. Methods Two hundred and thirty-seven patients with mild to moderate essential hypertension were enrolled in a randomized, double-blind, multi-center, paralleded and active-controlled trial, and were divided into olmesartan group (olmesartan 20 mg + losartan 50 mg placebo) and losartan group (losartan 50 mg + olmesartan 20 mg placebo) for a 8-week therapy. Four weeks after treatment, dosages of drugs were doubled in patients with seated diastolic blood pressure ≥90 mmHg (1 mmHg =0.133 kPa). All patients were followed up every two weeks, and the efficacy and adverse effects were observed. Another 32 patients with mild to moderate essential hypertension were enrolled and given olmesartan only, and ambulatory blood pressure monitoring was performed before and 8 weeks after treatment. Results Compared with those before treatment, both systolic blood pressure and diastolic blood pressure significantly decreased in olmesartan group and losartan group 8 weeks after treatment [(15.2 ±13.3) mmHg and (19.5 ±11.8) mmHg, respectively for systolic blood pressure (P <0.001); (15.9 ±7.48) mmHg and (16.2 ± 5.95) mmHg, respectively for diastolic blood pressure (P < 0.01) ], while there was no significant difference between these two groups (P > 0.05). There was no significant difference in total effective rate and incidence of adverse effect between these two groups (86.9% vs 93.7% and 7.63% vs 5.88% , P > 0.05) . Ambulatory blood pressure monitoring demonstrated that trough to peak ratios of systolic blood pressure and diastolic blood pressure were 86% and 71%, respectively. Conclusion Domestic olmesaratan provides an effective, safe and long action in the treatment of mild to moderate essential hypertension.

The short-term outcome of primary percutaneous coronary intervention for patients with acute myocardial infarction / 介入放射学杂志

Objective To evaluate the efficacy of primary percutaneous coronary intervention (PCI) for acute myocardial infarction. Methods 63 patients with acute myocardial infarction were treated by primary PCI within 12 hour from onset and were followed up for one to fourteen months. Results Procedure was successed in 61 patients (96.8%). Three patients received only primary angioplasty and 58 patients received stent implantation. All of them gained TIMI Ⅲ grade perfusion flow. Non-perfusion flow occurred in five patients but their flows were improved by intracoronary urokinase infusion. Ventricular tachycardia and fibrillation happened in five patients, and were converted to sinus rhythm by defibrillation in four and one died. Two of the five patients complicated with cardiogenic shock, with one died on 1st day and the other on 4th day after successful PCI, respectively. Main cardiac events occurred in five patients (17%) during follow-up with two sudden death , one reinfarction and repeated PCI, one received selective CABG and one PCI due to intrastent restenosis. Conclusions Primary PCI could provide higher successful rate of reperfusion with low hospital mortality and good short-term prognosis.

Effect of vitamin E on ox-LDL-induced monocyte/endothelium adhesion / 中国病理生理杂志

AIM: To observe the role of ox-LDL in rabbit endothelium/circulating monocyte adhesion in vitro and the effect of vitamin E. METHODS: Cultured rabbit's endothelial cells were incubated with different concentrations of ox-LDL, then incubated with rabbit's monocytes to observe cell's adhesion. With Northern blotting, endothelial VCAM-1 mRNA expression was measured. By using vitamin E incubation before ox-LDL, above steps were repeated to observe the effect of vitamin E. RESULTS: When ox-LDL concentrations were 2 5 mg/L, 5 mg/L, 10 mg/L, monocytes adhesive to endothelium per microscope field were 132 8?20 2, 350 0?37 2, 502 6?78 8, respectively They were all significantly higher than that of control group (51 2?7 7, P

Effects of BN50739, a PAF Antagonist, on Early Reperfusion-induced Arrhythmia in Rats / 第二军医大学学报

The present study investigated the effect of BN50739, a new PAF antagonist, on the early reperfusion-induced arrhythmia in anesthetized SD rats, and by this to elucidate the role of PAF in the mechanism of early reperfusion-induced arrhythmia. The results indicated that the BN50739 group had lower incidences of premature ventricular contraction (PVQ, ventricular tachycardia (VT) and ventricular fibrillation (VF) during reperfusion than the control group (58.3% vs 66.7%, 50% vs 77.8%, and 16.7% vs 88.9%). But only VF incidence had a significant difference. Also the BN50739 group had shorter duration of VT+VF and of total arrhythmias than control group (58.8+171.9 vs 296.4+291.4, and 76.4+173.9 vs 361.8 + 286.5, P