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Viruses ; 13(11)2021 10 30.
Artigo em Inglês | MEDLINE | ID: mdl-34834999

RESUMO

We introduce Viral Phrenology, a new scheme for understanding the genomic composition of spherical viruses based on the locations of their structural protrusions. We used icosahedral point arrays to classify 135 distinct viral capsids collected from over 600 capsids available in the VIPERdb. Using gauge points of point arrays, we found 149 unique structural protrusions. We then show how to use the locations of these protrusions to determine the genetic composition of the virus. We then show that ssDNA, dsDNA, dsRNA and ssRNA viruses use different arrangements for distributing their protrusions. We also found that Triangulation number is also partially dependent on the structural protrusions. This analysis begins to tie together Baltimore Classification and Triangulation number using point arrays.


Assuntos
Capsídeo/ultraestrutura , Frenologia , Vírus/genética , Vírus/ultraestrutura , Capsídeo/química , Microscopia Crioeletrônica , Cristalografia por Raios X , DNA de Cadeia Simples , Genoma Viral , Modelos Moleculares , Nanomedicina , Norovirus/genética , Norovirus/ultraestrutura , Parvoviridae/ultraestrutura , RNA de Cadeia Dupla , Vírion , Vírus/classificação
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