RESUMO
An experimental model of infection by Strongyloides ratti in the rat, which takes account of recent observations on the life cycle of the parasite, is described. The model is suitable for trial of anthelminthic drugs.
Assuntos
Anti-Helmínticos/uso terapêutico , Estrongiloidíase/tratamento farmacológico , Animais , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Fezes/parasitologia , Feminino , Larva/efeitos dos fármacos , Distribuição Aleatória , Ratos , Ratos Endogâmicos , Strongyloides/efeitos dos fármacos , Strongyloides/isolamento & purificação , Estrongiloidíase/parasitologiaRESUMO
The activity of albendazole and thiabendazole, two derivatives of benzimidazole, were tested in an experimental model of Strongyloides ratti infestation in the rat. Two series of seven consecutive daily negative parasitic plate cultures, separated by four weeks of steroid therapy, confirmed cure of the infestation. Both drugs were inactive against larvae in the tissue phase, but completely effective in the intestinal phase.
Assuntos
Anti-Helmínticos/uso terapêutico , Benzimidazóis/uso terapêutico , Estrongiloidíase/tratamento farmacológico , Tiabendazol/uso terapêutico , Albendazol , Animais , Feminino , Larva/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Strongyloides/efeitos dos fármacosRESUMO
Chondrosarcoma is a rare complication in hereditary multiple exostoses. The six patients in this study have had a complete follow-up and constitute the largest group of such cases to have been studied so far. Five patients had histologic evidence of malignancy. Since histologic examination can be very difficult, any other diagnostic features, may it be clinical, radiologic, or scintigraphical, should be taken into account for early surgical treatment. Bone scintigraphic examination is a valuable adjunct to early diagnosis of malignant change by showing highest uptake in malignant areas. It is also very useful for posttherapeutic follow-up.
