RESUMO
Studies investigating the association between IL-6/IL-6R axis and schizophrenia (SZ) susceptibility found inconsistent data. To reconcile the results, a systematic review followed by a meta-analysis was performed to assess the associations. This study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search of the literature was carried out in July 2022 using electronic databases PubMed, EBSCO, Science Direct, PsychInfo, and Scopus. Study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis. Fifty-eight studies were identified, including 4,200 SZ patients and 4,531 controls. Our meta-analysis results showed an increase of IL-6 levels in plasma, serum, or CSF and decreased IL-6R levels in serum in patients under treatment. Further studies are needed to better elucidate the correlation between the IL-6/IL-6R axis and the schizophrenia.
Assuntos
Interleucina-6 , Receptores de Interleucina-6 , Esquizofrenia , Humanos , Interleucina-6/sangue , Interleucina-6/líquido cefalorraquidiano , Interleucina-6/química , Plasma , Esquizofrenia/líquido cefalorraquidiano , Esquizofrenia/metabolismo , Receptores de Interleucina-6/sangue , Receptores de Interleucina-6/químicaRESUMO
Parvovirus B19 infection is asymptomatic in the majority of cases, but the are several well-known clinical manifestation. In adults transient aplastic crisis, chronic anemia, arthropathy, meningitis, encephalitis, myocarditis and acute hepatitis have been described. In this paper the Authors report two cases - arthropathy and acute hepatitis - of Parvovirus B19 infection in adults.
Assuntos
Artralgia/etiologia , Hepatite Viral Humana/etiologia , Infecções por Parvoviridae/diagnóstico , Parvovirus B19 Humano/patogenicidade , Adulto , Artralgia/virologia , Feminino , Hepatite Viral Humana/virologia , Humanos , Masculino , Pessoa de Meia-Idade , Infecções por Parvoviridae/complicações , Parvovirus B19 Humano/isolamento & purificaçãoAssuntos
Vírus da Dengue/fisiologia , Dengue/diagnóstico , Dengue/transmissão , Adulto , Anticorpos Antivirais/sangue , Anticorpos Antivirais/imunologia , Dengue/virologia , Vírus da Dengue/classificação , Vírus da Dengue/genética , Humanos , Itália , Masculino , Dados de Sequência Molecular , Filogenia , RNA Viral/genética , Proteínas Virais/genética , IêmenRESUMO
Histoplasmosis, worldwide diffuse mycosis, is known as opportunistic infection of AIDS in disseminated clinical pattern. The Authors report a case of disseminated histoplasmosis and Kaposi's sarcoma in a HIV positive patient.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Soropositividade para HIV/complicações , Neoplasias de Cabeça e Pescoço/complicações , Histoplasmose/diagnóstico , Sarcoma de Kaposi/complicações , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Adulto , Antifúngicos/uso terapêutico , Terapia Antirretroviral de Alta Atividade/métodos , Quimioterapia Combinada , Histoplasmose/tratamento farmacológico , Homossexualidade Masculina , Humanos , MasculinoRESUMO
Local immunotherapy with bacillus Calmette-Guerin (BCG) is an effective and frequently used treatment for superficial bladder cancer. Serious side effects are infrequent but can affect every organ system. We describe a 53 year- old man with a disseminated bacillus Calmette-Guerin (BCG) infection after intravescical instillation for bladder carcinoma. Recent literature is reviewed for this rare complication.