RESUMO
This is the first description of a dystrophin-deficient muscular dystrophy in domestic cats. The disorder appears to be of X-linked inheritance because it affected both males of a litter of four kittens. Immunoblotting and immunofluorescent detection of dystrophin showed dystrophin present in control cat muscle but no detectable dystrophin in either affected cat. The feline muscular dystrophy was progressive and histopathologically resembled human Duchenne/Becker muscular dystrophy except for the lack of fat infiltration and the presence of prominent hypertrophy of both muscle fibers and muscles groups in the feline disorder.
Assuntos
Doenças do Gato/genética , Distrofia Muscular Animal/genética , Animais , Gatos , Distrofina , Imunofluorescência , Histocitoquímica , Immunoblotting , Masculino , Proteínas Musculares/genética , Músculos/análise , Músculos/patologia , Distrofia Muscular Animal/patologia , Cromossomo XRESUMO
We report the clinical and immunohistochemical features of six cases of intravascular lymphomatosis. All patients presented with symptoms referable to central nervous system (CNS) involvement. In two patients, the diagnosis was made on brain biopsy specimens. In the remaining four cases, diagnosis was made at autopsy. Three of the four autopsied patients had focal extravascular lymphoma, diffuse large cell type. In all five cases tested, immunohistochemical stains on paraffin-embedded sections confirmed the lymphoid nature of the malignant cells. Stains on frozen sections in one case, and on paraffin-embedded tissue in the other four cases, demonstrated B-lymphocyte lineage. In the remaining case, electron microscopy confirmed the lymphoid nature of the tumor cells. All three cases tested expressed the Hermes 3-defined homing receptor antigen and lacked peanut agglutinin receptors. Our results are consistent with other reports confirming the lymphoid nature of so-called malignant angioendotheliomatosis. Our limited analysis of surface receptor molecules suggests that the expression of the homing receptor for high endothelial venules is not in itself responsible for the unusual intravascular location of these cells.
Assuntos
Linfócitos B/patologia , Leucemia Linfocítica Crônica de Células B/patologia , Receptores de Antígenos de Linfócitos B/análise , Tromboembolia/patologia , Idoso , Idoso de 80 Anos ou mais , Capilares/ultraestrutura , Feminino , Humanos , Técnicas Imunoenzimáticas , Leucemia Linfocítica Crônica de Células B/complicações , Leucemia Linfocítica Crônica de Células B/ultraestrutura , Masculino , Pessoa de Meia-Idade , Células Neoplásicas Circulantes , Doenças do Sistema Nervoso/etiologia , Doenças do Sistema Nervoso/patologia , Tromboembolia/complicações , Vênulas/ultraestruturaRESUMO
A 40 year old man developed seizures, intermittent fever, and progressive dementia ending in coma and death after four years. The cerebrospinal fluid showed variable pleocytosis and occasional elevation of protein. The necropsy revealed many lesions characteristic of Whipple's disease confined to the grey matter of the brain. The pathological changes were studied with the light and electron microscope. The findings permitted an understanding of the temporal sequence of changes in the lesions. Involvement of the brain in this condition is rare, but the disease is treatable and the diagnosis can be made by brain biopsy.