RESUMO
Pleomorphic ductal carcinoma of the breast is a rare variant included in the morphological group of infiltrating ductal carcinoma. The pleomorphic carcinoma is composed predominantly of epithelial and multinucleated tumor giant cells. We report here two cases presenting a lesion composed microscopically of a proliferation of large pleomorphic cells with a predominance of multinucleated giant cells. These lesions were negative for estrogen receptor, progesterone receptor and Her2-neu (triple-negative phenotype). Basal markers (cytokeratin 5/6, cytokeratin 17 and epidermal growth factor receptor [EGFR]) were present, accompanied by the presence of histiocyte marker CD163 in most neoplastic giant cells. High-grade pleomorphic breast carcinomas with the triple-negative phenotype and expression of basal markers might be included in the basal subtype. This is the first report about the co-expression of macrophage marker CD163, with tumor (P53) or epithelial markers (CAM5.2), as indicated by double immunohistochemistry in pleomorphic ductal carcinoma of the breast.
Assuntos
Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/patologia , Células Gigantes/patologia , Macrófagos/patologia , Idoso , Antígenos CD/metabolismo , Antígenos de Diferenciação Mielomonocítica/metabolismo , Biomarcadores/metabolismo , Biomarcadores Tumorais/metabolismo , Neoplasias da Mama/metabolismo , Neoplasias da Mama/cirurgia , Carcinoma Ductal de Mama/metabolismo , Carcinoma Ductal de Mama/cirurgia , Receptores ErbB/metabolismo , Feminino , Células Gigantes/metabolismo , Humanos , Queratinas/metabolismo , Macrófagos/metabolismo , Pessoa de Meia-Idade , Receptores de Superfície Celular/metabolismo , Proteína Supressora de Tumor p53/metabolismoRESUMO
OBJECTIVES: To report one case of primary adenocarcinoma of the seminal vesicles. METHODS/RESULTS: We report the case of a 69-year-old man with obstructive voiding symptoms. Digital rectal examination reveals a marked enlargement of posterior area of the prostate and surrounding tissues. Transrectal needle biopsy shows a primary adenocarcinoma of the seminal vesicles. CONCLUSION: Primary adenocarcinoma of the seminal vesicles is an extremely uncommon neoplasm that is often difficult to diagnose as it has in specific morphology and can be confused with other primary adenocarcinomas from prostate, bladder or colon.
Assuntos
Adenocarcinoma , Neoplasias dos Genitais Masculinos , Glândulas Seminais , Adenocarcinoma/patologia , Idoso , Neoplasias dos Genitais Masculinos/patologia , Humanos , MasculinoRESUMO
OBJETIVOS: Presentar un caso de adenocarcinoma primario de vesícula seminal.MÉTODO/RESULTADOS: Varón de 69 años con síntomas de uropatía obstructiva, que presenta al tacto rectal un agrandamiento del área posterior de la próstata y tejidos adyacentes. La biopsia transrectal revela un adenocarcinoma papilar primario de vesículas seminales.CONCLUSIÓN: El adenocarcinoma primario de vesículas seminales es una neoplasia extremadamente infrecuente, que es de difícil diagnóstico tanto por su morfología inespecífica como por su localización, dado que se puede confundir con otros adenocarcinomas primarios como de la próstata, vejiga o recto(AU)
OBJECTIVES:To report one case of primary adenocarcinoma of the seminal vesicles.METHODS/ RESULTS: We report the case of a 69-year-old man with obstructive voiding symptoms. Digital rectal examination reveals a marked enlargement of posterior area of the prostate and surrounding tissues. Transrectal needle biopsy shows a primary adenocarcinoma of the seminal vesicles.CONCLUSION: Primary adenocarcinoma of the seminal vesicles is an extremely uncommon neoplasm that is often difficult to diagnose as it has inespecific morphology and can be confused with other primary adenocarcinomas from prostate, bladder or colon(AU)
