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1.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;33(11): 1343-50, Nov. 2000. tab, graf
Artigo em Inglês | LILACS | ID: lil-273209

RESUMO

Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40-day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops(r)). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 +/- 0.44 pellets and midazolam group: 3.60 +/- 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 +/- 0.44 pellets and stressed group: 4.18 +/- 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/water group: 4.18 +/- 0.58 pellets; stressed/midazolam group: 3.2 +/- 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect


Assuntos
Animais , Ratos , Masculino , Ansiolíticos/farmacologia , Sacarose Alimentar , Comportamento Alimentar/efeitos dos fármacos , Midazolam/farmacologia , Estresse Psicológico , Análise de Variância , Peso Corporal , Estudos de Casos e Controles , Ratos Wistar , Restrição Física
2.
Braz J Med Biol Res ; 33(11): 1343-50, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11050666

RESUMO

Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40-day treatment). The animals were placed in a lighted area in the presence of 10 pellets of sweet food (Froot loops). The number of ingested pellets was measured during a period of 3 min, in the presence or absence of fasting. The group chronically treated with midazolam alone presented increased ingestion when compared to control animals (control group: 2.0 +/- 0.44 pellets and midazolam group: 3.60 +/- 0.57 pellets). The group submitted to restraint stress presented an increased ingestion compared to controls (control group: 2.0 +/- 0.44 pellets and stressed group: 4.18 +/- 0.58 pellets). Chronically administered midazolam reduced the ingestion in stressed animals (stressed/water group: 4.18 +/- 0.58 pellets; stressed/midazolam group: 3.2 +/- 0.49 pellets). Thus, repeated stress increases appetite for sweet food independently of hunger and chronic administration of midazolam can decrease this behavioral effect.


Assuntos
Ansiolíticos/farmacologia , Sacarose Alimentar , Comportamento Alimentar/efeitos dos fármacos , Midazolam/farmacologia , Estresse Psicológico , Análise de Variância , Animais , Peso Corporal , Masculino , Ratos , Ratos Wistar , Restrição Física
3.
Braz J Med Biol Res ; 23(9): 805-9, 1990.
Artigo em Inglês | MEDLINE | ID: mdl-2101320

RESUMO

A test for recent memory was developed using non-verbal material. The present report describes a series of experiments conducted to evaluate its reproducibility and the influences of changes in the interval between acquisition and retrieval, and age and level of instruction, and its sensitivity to the integrity of memory function. A total of 114 subjects participated in 5 experiments. The test of recent memory is reproducible over a period of at least 5 months and can be used with training-testing intervals of 24 to 48 h. The performance of the test is affected by age and level of instruction. Moreover, the memory test is sensitive to differences in the integrity of memory function. Thus, the memory test developed in this study may be used to evaluate the effects of behavioral and/or pharmacological manipulations on recent memory in homogeneous groups of subjects.


Assuntos
Memória de Curto Prazo , Testes Neuropsicológicos , Adolescente , Adulto , Idoso , Análise de Variância , Escolaridade , Humanos , Pessoa de Meia-Idade , Retenção Psicológica
4.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;23(9): 805-9, 1990. tab
Artigo em Inglês | LILACS | ID: lil-92398

RESUMO

A test for recent memory was developed using non-verbal material. The present report describes a series of experiments conducted to evaluate its reproducibility and the influences of changes in the interval between acquisition and tetrieval, and age and level of instruction, and its sensitivity to the integrity of memory function. A total of 114 subjects participated in 5 experiments. The test of recent memory is reproducible over a period of at least 5 months and can be used with training-testing intervals of 24 to 48h. The performance of the test is affected by age and level of instruction. Moreover, thre memory test is sensitive to differences in the integrity of memory function. Thus, the memory test developed in this study may be used to evaluate the effects of behavioral and/or pharmacological manipulations on recent memory in homogeneous groups of subjects


Assuntos
Humanos , Escolaridade , Memória , Testes Neuropsicológicos , Análise de Variância , Escolaridade , Retenção Psicológica
5.
Psychopharmacology (Berl) ; 94(3): 402-4, 1988.
Artigo em Inglês | MEDLINE | ID: mdl-3128818

RESUMO

Rats were submitted to a training and a test session of shuttle avoidance. Exposure to a session of extinction of this task either 2 or 24 h after training interfered with retention test performance. Exposure to an open field 2, but not 24 h after the avoidance training also interfered with retention. Diazepam blocked the deleterious effect of extinction and of the open field on retention of the avoidance task. Diazepam alone had no effect when given after avoidance training; it did, however, also interfere with retention when given prior to training. It is likely, therefore, that diazepam cancelled the effect of the extinction or of the open field on avoidance retention because of anterograde amnesia (i.e., it prevented the recording of these tasks). The deleterious effect of the open field on retention of shuttle avoidance can be explained by retroactive interference caused by the addition of information. It is not due to a direct influence on retrieval, it is not due to extinction, and it had to be recorded 2 h after training in order to the effective.


Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Comportamento Animal/efeitos dos fármacos , Diazepam/farmacologia , Animais , Extinção Psicológica/efeitos dos fármacos , Feminino , Ratos , Ratos Endogâmicos
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