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1.
BMJ ; 382: 1716, 2023 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-37527883
2.
BMJ ; 382: 1988, 2023 08 31.
Artigo em Inglês | MEDLINE | ID: mdl-37652536
3.
BMJ ; 382: p1206, 2023 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-37442568
4.
BMJ ; 381: 1238, 2023 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-37257899
5.
BMJ ; 380: 462, 2023 03 06.
Artigo em Inglês | MEDLINE | ID: mdl-36878604
8.
BMJ ; 380: 323, 2023 02 08.
Artigo em Inglês | MEDLINE | ID: mdl-36754444

Assuntos
Afeto , Estudantes , Humanos
9.
BMJ ; 380: 460, 2023 02 27.
Artigo em Inglês | MEDLINE | ID: mdl-36849189
10.
BMJ ; 380: p164, 2023 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-36690375
12.
BMJ ; 379: o2819, 2022 11 23.
Artigo em Inglês | MEDLINE | ID: mdl-36418031
13.
BMJ ; 379: o2553, 2022 10 26.
Artigo em Inglês | MEDLINE | ID: mdl-36288804

Assuntos
Estudantes , Tremor , Humanos
14.
Int J Eat Disord ; 54(8): 1549-1554, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34137051

RESUMO

OBJECTIVE: CBT-T is a relatively new, brief cognitive behavioral therapy eating disorder treatment for non-underweight patients. This study evaluates CBT-T independently from the team that developed the protocol, and examines the relationship between eating disorder duration and CBT-T effectiveness. METHOD: A case series design was used, comprising N = 40 adults with bulimia or atypical anorexia type eating disorders. CBT-T was delivered by CBT therapists in a specialist outpatient service. Mixed model analysis examined the interactions between eating disorder duration and change to eating disorder psychopathology and secondary impairment from pre-post treatment. Abstinence, good outcome, and remission rates were also provided. RESULTS: Intervention effect sizes were large. Treatment completers reported abstinence from binge eating and purging over the final 28-days, and 7-days of treatment at 30.1%, and 73.1%, respectively; 76.9% reported good outcome; and 23.1% reported remission. No relationship between eating disorder duration and treatment effectiveness was found. DISCUSSION: These findings build on existing evidence supporting provision of CBT-T in routine clinical practice, for patients with eating disorders of any duration. Replication, extension, and RCT will strengthen comparability with other evidence-based approaches.


Assuntos
Transtorno da Compulsão Alimentar , Bulimia Nervosa , Terapia Cognitivo-Comportamental , Adulto , Humanos , Psicopatologia , Resultado do Tratamento
15.
Clin Child Fam Psychol Rev ; 21(2): 246-265, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29450764

RESUMO

Siblings of children and young people with a chronic illness are at increased risk of poor psychological functioning. A number of studies have attempted to implement and evaluate interventions targeting the psychological well-being of this at-risk group. This systematic review summarises the evidence regarding psychological functioning of siblings following an intervention targeting their well-being. The meta-analysis considered behaviour and knowledge, two of the most frequently studied outcomes. The following databases were used: PsycINFO, EMBASE, CINAHL, PubMed, Scopus and Web of Science. Seventeen studies were eligible to be included in the systematic review and eight in the meta-analysis. Results from the systematic review reflected the inconsistency of intervention evaluations in this area with a high level of heterogeneity and a total of 23 outcomes considered across the 17 included studies. The meta-analysis estimated effect sizes using a standardised mean difference (SMD) approach. Pre-post analysis suggested significant improvement in behavioural outcomes and knowledge of their sibling's health conditions with a SMD of - 0.44 [95% CI (- 0.6, - 0.29); p = 0.000] and 0.69 [(95% CI = 0.42, 0.96); p = 0.000], respectively. The SMD was not significant for behavioural outcomes when considering treatment-control studies. In conclusion, the findings suggest interventions for well-being have a positive effect on the psychological functioning of siblings of children and young people with a chronic illness, but their specificity needs to be established. There is a need for further, more methodologically robust research in this area.


Assuntos
Doença Crônica , Avaliação de Resultados em Cuidados de Saúde , Psicoterapia , Grupos de Autoajuda , Irmãos , Adolescente , Criança , Doença Crônica/psicologia , Humanos , Irmãos/psicologia
16.
Int J Eat Disord ; 50(12): 1350-1355, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28884837

RESUMO

OBJECTIVE: This study aimed to determine whether cognitive-behavioral therapy (CBT) for eating disorders can be effective in a routine, primary care clinical setting, and to assess dose response. METHOD: The participants were 47 patients who commenced treatment with a publicly-funded primary care eating disorder service. They attended 7-33 sessions of individual CBT (mean = 17), using an evidence-based approach. Routine measures were collected pre- and post-therapy. RESULTS: Three-quarters of the patients completed treatment. Using intention to treat analysis (multiple imputation), the patients showed substantial improvements in eating attitudes, bulimic behaviors, and depression. However, there was no association between the level of improvement and the length of therapy past the 8th to 12th session. DISCUSSION: The level of effectiveness shown here is comparable to that previously demonstrated by more specialist services in secondary and tertiary care. The nonlinear association between number of sessions and recovery highlights the importance of early change, across the eating disorders.


Assuntos
Terapia Cognitivo-Comportamental/métodos , Transtornos da Alimentação e da Ingestão de Alimentos/terapia , Adolescente , Adulto , Feminino , Humanos , Masculino , Atenção Primária à Saúde , Resultado do Tratamento , Adulto Jovem
17.
Cell Mol Life Sci ; 68(18): 3121-31, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21290164

RESUMO

Krueppel-like factor 4 (Klf4) belongs to the Sp/Klf family of zinc-finger transcription factors and is indispensable for terminal maturation of epithelial tissues. Furthermore, it is part of a small set of proteins that are used to generate pluripotent embryonic stem cells from differentiated tissues. Herein, we describe that a Klf4 zinc-finger domain mutant induces self-renewal and block of maturation, while wild-type Klf4 induces terminal macrophage differentiation. Moreover, we present the crystal structure of the zinc-finger domain of Klf4 bound to its target DNA, revealing that primarily the two C-terminal zinc-finger motifs are required for site specificity. Lack of those two zinc fingers leads to deficiency of Klf4 to induce macrophage differentiation. The first zinc finger, on the other hand, inhibits the otherwise cryptic self-renewal and block of differentiation activity of Klf4. Our data show that impairing the DNA binding could potentially contribute to a monocytic leukemia.


Assuntos
Diferenciação Celular/fisiologia , DNA/metabolismo , Fatores de Transcrição Kruppel-Like/genética , Macrófagos/fisiologia , Modelos Moleculares , Ligação Proteica , Dedos de Zinco/genética , Sequência de Aminoácidos , Animais , Ensaio de Unidades Formadoras de Colônias , Cristalização , Citometria de Fluxo , Fator 4 Semelhante a Kruppel , Fatores de Transcrição Kruppel-Like/química , Fatores de Transcrição Kruppel-Like/metabolismo , Leucemia Monocítica Aguda/etiologia , Camundongos , Camundongos Endogâmicos C57BL , Dados de Sequência Molecular , Estrutura Molecular , Plasmídeos/genética , Retroviridae , Difração de Raios X
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